Cytosine methylation in the EcoRI site of active and inactive herpesvirus thymidine kinase promoters

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

DNA METHYLATION AND GENE ACTIVITY

1983 • 1,115 citations

DNA methylation and gene activity

1988 • 904 citations

Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro

1985 • 805 citations

5-Methylcytosine in Eukaryotic DNA

1981 • 744 citations

Homologous recognition of a promoter domain common to the MSV LTR and the HSV tk gene

1986 • 562 citations

Altering gene expression with 5-azacytidine

1985 • 408 citations

Alkaline transfer of DNA to plastic membrane

1984 • 285 citations

Isolation of probes detecting restriction fragment length polymorphisms from X chromosome-specific libraries: potential use for diagnosis of Duchenne muscular dystrophy

1985 • 217 citations

Construction and characterization of new cloning vehicles VI. Plasmid pBR329, a new derivative of pBR328 lacking the 482-base-pair inverted duplication

1982 • 212 citations

Non‐producer human cells induced by murine sarcoma virus

1975 • 204 citations

5-Azacytidine-Induced Reactivation of a Herpes Simplex Thymidine Kinase Gene

1982 • 144 citations

The effects of base analogue substitutions on the cleavage by the EcoRI restriction endonuclease of octadeoxyribonucleotides containing modified EcoRI recognition sequences.

1986 • 131 citations

Factors governing the expression of a bacterial gene in mammalian cells.

1981 • 126 citations

Site specific demethylation in the promoter of human gamma-globin gene does not alleviate methylation mediated suppression.

1987 • 105 citations

Methylation of the mouse hprt gene differs on the active and inactive X chromosomes.

1986 • 105 citations

Specificity of restriction endonucleases and methylases — a review (edition 2)

1986 • 104 citations

Promoter domains required for expression of plasmid-borne copies of the herpes simplex virus thymidine kinase gene in virus-infected mouse fibroblasts and microinjected frog oocytes.

1985 • 96 citations

Deoxyribonucleic acid-mediated gene transfer in mammalian cells: molecular analysis of unstable transformants and their progression to stability.

1981 • 80 citations

Methylation of single CpG dinucleotides within a promoter element of the Herpes simplex virus tk gene reduces its transcription in vivo

1988 • 57 citations

Transcription of herpes simplex virus genes in vivo: overlap of a late promoter with the 3' end of the early thymidine kinase gene

1983 • 50 citations

Mechanism of action of rat liver DNA methylase

1971 • 47 citations

De novo methylation as major event in the inactivation of transfected herpesvirus thymidine kinase genes in human cells

1989 • 21 citations

Phenotypic Variation Associated with Molecular Alterations at a Cluster of Thymidine Kinase Genes

1983 • 18 citations

Changes in Structure and Methylation Pattern in a Cluster of Thymidine Kinase Genes

1984 • 17 citations

Phenotypic variation associated with molecular alterations at a cluster of thymidine kinase genes.

1983 • 13 citations

Changes in structure and methylation pattern in a cluster of thymidine kinase genes.

1984 • 9 citations