Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism

Role of AMP-activated protein kinase in mechanism of metformin action

2001 • 5,086 citations

Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

2004 • 4,503 citations

Anemia of Chronic Disease

2005 • 3,522 citations

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

2004 • 2,160 citations

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

2004 • 2,011 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload

2001 • 1,673 citations

A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva

2006 • 1,145 citations

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

2006 • 994 citations

Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis

2003 • 979 citations

Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells

2005 • 979 citations

Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

2002 • 888 citations

Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter

2002 • 849 citations

Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos

1996 • 653 citations

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

2005 • 599 citations

Signal transduction of bone morphogenetic protein receptors

2003 • 512 citations

Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α

2006 • 507 citations

Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling

1998 • 458 citations

Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance

2007 • 449 citations

BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways

2004 • 424 citations

Ventral and Lateral Regions of the Zebrafish Gastrula, Including the Neural Crest Progenitors, Are Established by abmp2b/swirlPathway of Genes

1998 • 424 citations

Roles of Bone Morphogenetic Protein Type I Receptors and Smad Proteins in Osteoblast and Chondroblast Differentiation

1999 • 419 citations

Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes

1996 • 408 citations

Consequences of knocking out BMP signaling in the mouse

2002 • 363 citations

Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis

2003 • 312 citations

Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6

2006 • 306 citations

C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase

2004 • 297 citations

Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio

1996 • 289 citations

From developmental disorder to heritable cancer: it's all in the BMP/TGF-β family

2003 • 270 citations

BMP2-induced Apoptosis Is Mediated by Activation of the TAK1-p38 Kinase Pathway That Is Negatively Regulated by Smad6

2000 • 242 citations

Analysis of a Zebrafish VEGF Receptor Mutant Reveals Specific Disruption of Angiogenesis

2002 • 226 citations

The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE- , transferrin receptor 2-, and β ₂ -microglobulin-deficient hepatocytes

2004 • 220 citations

Id: A Target of BMP Signaling

2002 • 219 citations

Bone Morphogenetic Protein (BMP) Type II Receptor Deletion Reveals BMP Ligand-specific Gain of Signaling in Pulmonary Artery Smooth Muscle Cells

2005 • 207 citations

Repulsive Guidance Molecule (RGMa), a DRAGON Homologue, Is a Bone Morphogenetic Protein Co-receptor

2005 • 195 citations

Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions

2005 • 155 citations

lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation

2001 • 152 citations

Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction

2004 • 144 citations

Transgenic zebrafish reveal stage-specific roles for Bmp signaling in ventral and posterior mesoderm development

2005 • 143 citations

Three Different noggin Genes Antagonize the Activity of Bone Morphogenetic Proteins in the Zebrafish Embryo

1999 • 136 citations

Evidence That Inhibition of Hemojuvelin Shedding in Response to Iron Is Mediated through Neogenin

2007 • 120 citations

BMP‐7 functions as a novel hormone to facilitate liver regeneration

2006 • 120 citations

Extracellular modulation of BMP activity in patterning the dorsoventral axis

2006 • 112 citations

Synthesis and Initial SAR Studies of 3,6-Disubstituted Pyrazolo[1,5-a]pyrimidines: A New Class of KDR Kinase Inhibitors

2002 • 110 citations

AMPK regulation of mouse oocyte meiotic resumption in vitro

2006 • 103 citations

Ferroportin1 is required for normal iron cycling in zebrafish

2005 • 88 citations

Identification of receptors and Smad proteins involved in activin signalling in a human epidermal keratinocyte cell line

1998 • 75 citations

Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning

2004 • 66 citations

Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos

2004 • 48 citations

Adenovirus-mediated overexpression of follistatin enlarges intact liver of adult rats

2003 • 41 citations