Analysis of Smad nucleocytoplasmic shuttling in living cells

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

2003 • 5,611 citations

Transport Between the Cell Nucleus and the Cytoplasm

1999 • 2,001 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7

2002 • 1,572 citations

Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

2000 • 1,299 citations

New insights into TGF-β–Smad signalling

2004 • 1,169 citations

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

2003 • 1,115 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

2001 • 828 citations

The Glucocorticoid Receptor: Rapid Exchange with Regulatory Sites in Living Cells

2000 • 791 citations

The POZ domain: a conserved protein-protein interaction motif.

1994 • 770 citations

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

1987 • 699 citations

DPC4 gene in various tumor types.

1996 • 680 citations

Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542

2002 • 609 citations

Three-dimensional structure of β-galactosidase from E. coli.

1994 • 589 citations

Photobleaching and photoactivation: following protein dynamics in living cells.

2003 • 414 citations

Nucleocytoplasmic Shuttling of Smads 2, 3, and 4 Permits Sensing of TGF-β Receptor Activity

2002 • 397 citations

TGFβ receptor internalization into EEA1-enriched early endosomes

2002 • 298 citations

Imaging Protein Kinase Cα Activation in Cells

1999 • 291 citations

Microtubule Binding to Smads May Regulate TGFβ Activity

2000 • 277 citations

Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif

2000 • 277 citations

Transforming Growth Factor β-Independent Shuttling of Smad4 between the Cytoplasm and Nucleus

2000 • 266 citations

Smad3-Smad4 and AP-1 Complexes Synergize in Transcriptional Activation of the c-Jun Promoter by Transforming Growth Factor β

1999 • 261 citations

Endogenous patterns of TGFβ superfamily signaling during early Xenopus development

2000 • 256 citations

Smad2 Nucleocytoplasmic Shuttling by Nucleoporins CAN/Nup214 and Nup153 Feeds TGFβ Signaling Complexes in the Cytoplasm and Nucleus

2002 • 252 citations

Dynamic behavior of transcription factors on a natural promoter in living cells

2002 • 214 citations

Dynamic Shuttling and Intranuclear Mobility of Nuclear Hormone Receptors

2003 • 182 citations

Molecular Determinants of Glucocorticoid Receptor Mobility in Living Cells: the Importance of Ligand Affinity

2003 • 173 citations

Importin β Mediates Nuclear Translocation of Smad 3

2000 • 165 citations

The nuclear import function of Smad2 is masked by SARA and unmasked by TGFb-dependent phosphorylation

2000 • 165 citations

Transforming Growth Factor-β Induces Nuclear Import of Smad3 in an Importin-β1 and Ran-dependent Manner

2001 • 165 citations

The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF‐β/Smad signalling

2002 • 150 citations

Attenuation of the TGF-β-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-β-induced growth arrest

2003 • 140 citations

Regulation of intracellular dynamics of Smad4 by its leucine‐rich nuclear export signal

2000 • 139 citations

A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation

2000 • 136 citations

Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor β Independent of Smad2 and Smad3

2003 • 136 citations

Distinct Domain Utilization by Smad3 and Smad4 for Nucleoporin Interaction and Nuclear Import

2003 • 118 citations

An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity

2003 • 110 citations

Protein Mobility within the Nucleus—What Are the Right Moves?

2001 • 98 citations

Stoichiometry of Active Smad-Transcription Factor Complexes on DNA

2002 • 90 citations

STAT1 from the cell membrane to the DNA

2001 • 89 citations

In or out? The dynamics of Smad nucleocytoplasmic shuttling

2003 • 82 citations

Facilitated Nucleocytoplasmic Shuttling of the Ran Binding Protein RanBP1

2000 • 78 citations

Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells

2004 • 73 citations

Protein dynamics in the nuclear compartment

2002 • 71 citations