Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor β Independent of Smad2 and Smad3

Role of Transforming Growth Factor β in Human Disease

2000 • 2,405 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

Controlling TGF-beta signaling.

2000 • 1,806 citations

Controlling TGF-β signaling

2000 • 1,522 citations

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

1999 • 1,048 citations

Transforming Growth Factor-β1 Mediates Epithelial to Mesenchymal Transdifferentiation through a RhoA-dependent Mechanism

2001 • 993 citations

PAK Kinases Are Directly Coupled to the PIX Family of Nucleotide Exchange Factors

1998 • 745 citations

Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

1997 • 742 citations

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

1999 • 667 citations

Mechanisms of Myofibroblast Activity and Phenotypic Modulation

1999 • 580 citations

Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription

1999 • 534 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

Structure of PAK1 in an Autoinhibited Conformation Reveals a Multistage Activation Switch

2000 • 515 citations

Regulation of cell proliferation by Smad proteins

2002 • 448 citations

Functional Characterization of Transforming Growth Factor β Signaling in Smad2- and Smad3-deficient Fibroblasts

2001 • 397 citations

PAK to the future

1999 • 391 citations

p21-Activated kinases: three more join the Pak

2002 • 370 citations

p21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis

2000 • 356 citations

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.

1995 • 306 citations

TGFβ receptor internalization into EEA1-enriched early endosomes

2002 • 298 citations

Mice Lacking Smad3 Are Protected Against Cutaneous Injury Induced by Ionizing Radiation

2002 • 281 citations

Activation of Cdc42, Rac, PAK, and Rho-Kinase in Response to Hepatocyte Growth Factor Differentially Regulates Epithelial Cell Colony Spreading and Dissociation

2000 • 276 citations

Requirement for PAK4 in the Anchorage-independent Growth of Human Cancer Cell Lines

2002 • 262 citations

The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway

2001 • 246 citations

Transforming Growth Factor- β₁ Induces Phenotypic Modulation of Human Lung Fibroblasts to Myofibroblast Through a c-Jun-NH₂-Terminal Kinase-Dependent Pathway

2001 • 212 citations

Transforming growth factor beta 1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest.

1991 • 203 citations

Transforming growth factor-β signal transduction in epithelial cells

2001 • 194 citations

The p21Rac/Cdc42-activated kinases (PAKs)

1998 • 190 citations

Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway

1998 • 187 citations

Internalization-Dependent and -Independent Requirements for Transforming Growth Factor β Receptor Signaling via the Smad Pathway

2002 • 187 citations

Activated PAK4 Regulates Cell Adhesion and Anchorage-Independent Growth

2001 • 166 citations

Androgen Receptor Specifically Interacts with a Novel p21-activated Kinase, PAK6

2001 • 158 citations

Chronic liver injury, TGF-β, and cancer

2001 • 156 citations

PAK4 is activated via PI3K in HGF-stimulated epithelial cells

2002 • 109 citations

Regulation of Cell Function by Rho Family GTPases

2000 • 100 citations

TGF‐β inhibits growth factor‐induced DNA synthesis in hamster fibroblasts without affecting the early mitogenic events

1988 • 99 citations

Differential effects of epidermal growth factor, transforming growth factor, and insulin on DNA and protein synthesis and morphology in serum-free cultures of AKR-2B cells.

1984 • 93 citations

Vascular Smooth Muscle α-Actin Gene Transcription during Myofibroblast Differentiation Requires Sp1/3 Protein Binding Proximal to the MCAT Enhancer

2002 • 67 citations

p21-activated Protein Kinase γ-PAK Is Translocated and Activated in Response to Hyperosmolarity

2000 • 62 citations

Platelet-derived Growth Factor Requires Epidermal Growth Factor Receptor to Activate p21-activated Kinase Family Kinases

2001 • 59 citations

Differential Requirement for Type I and Type II Transforming Growth Factor β Receptor Kinase Activity in Ligand-mediated Receptor Endocytosis

1998 • 55 citations

Heteromeric and Homomeric Transforming Growth Factor-β Receptors Show Distinct Signaling and Endocytic Responses in Epithelial Cells

1998 • 50 citations

Transforming Growth Factor β Receptor Signaling and Endocytosis Are Linked through a COOH Terminal Activation Motif in the Type I Receptor

2001 • 48 citations

Functional interaction between c-Abl and the p21-activated protein kinase γ-PAK

2000 • 47 citations

Evidence That Smad2 Is a Tumor Suppressor Implicated in the Control of Cellular Invasion

1999 • 47 citations

Cytostatic p21 G protein-activated protein kinase γ-PAK

2001 • 46 citations

Chimeric Granulocyte/Macrophage Colony-stimulating Factor/Transforming Growth Factor-β (TGF-β) Receptors Define a Model System for Investigating the Role of Homomeric and Heteromeric Receptors in TGF-β Signaling

1996 • 44 citations

Transforming Growth Factor β1 Inhibition of p34^cdc2 Phosphorylation and Histone H1 Kinase Activity Is Associated with G1/S-Phase Growth Arrest

1991 • 31 citations

NGF exhibits a pro‐apoptotic activity for human vascular smooth muscle cells that is inhibited by TGFβ1

1997 • 20 citations