C2 Region-derived Peptides Inhibit Translocation and Function of β Protein Kinase C in Vivo

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface

1992 • 968 citations

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

1990 • 829 citations

THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONS

1989 • 739 citations

Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.

1994 • 715 citations

The structure, expression, and properties of additional members of the protein kinase C family.

1988 • 706 citations

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

1995 • 680 citations

The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue

1995 • 627 citations

Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease.

1983 • 601 citations

Identification of intracellular receptor proteins for activated protein kinase C.

1991 • 505 citations

Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.

1989 • 439 citations

A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family

1988 • 414 citations

Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain.

1994 • 352 citations

Localization of Protein Kinase C Isozymes in Cardiac Myocytes

1994 • 342 citations

PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system.

1995 • 297 citations

Protein kinase C — a family affair

1989 • 289 citations

Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosis

1993 • 282 citations

A protein kinase C isozyme is translocated to cytoskeletal elements on activation.

1990 • 257 citations

Protein kinase C contains two phorbol ester binding domains.

1991 • 234 citations

Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme

1991 • 212 citations

The induction of oocyte maturation: transmembrane signaling events and regulation of the cell cycle

1989 • 189 citations

Domain structure and phosphorylation of protein kinase C.

1987 • 168 citations

Protein Kinase C Located in Rat Liver Nuclei

1989 • 145 citations

Factors influencing chelator-stable, detergent-extractable, phorbol diester-induced membrane association of protein kinase C. Differences between Ca2+-induced and phorbol ester-stabilized membrane bindings of protein kinase C.

1986 • 144 citations

Membrane cell permeabilisation with saponin and multiparametric analysis by flow cytometry

1991 • 144 citations

Peptides that mimic the pseudosubstrate region of protein kinase C bind to acidic lipids in membranes

1991 • 139 citations

Protein kinase C epsilon is localized to the Golgi via its zinc-finger domain and modulates Golgi function.

1995 • 133 citations

Protein kinase C in fibroblasts. Characteristics of its intracellular location during growth and after exposure to phorbol esters and other mitogens.

1987 • 127 citations

Agonists and antagonists of protein kinase C function, derived from its binding proteins.

1994 • 125 citations

Interaction cloning of protein kinase C substrates.

1993 • 122 citations

A synthetic peptide of the rab3a effector domain stimulates amylase release from permeabilized pancreatic acini.

1992 • 117 citations

Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.

1989 • 117 citations

p65 Fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C

1992 • 105 citations

A phorbol ester binding domain of protein kinase C gamma. Deletion analysis of the Cys2 domain defines a minimal 43-amino acid peptide.

1994 • 105 citations

Deletion of the regulatory domain of protein kinase C alpha exposes regions in the hinge and catalytic domains that mediate nuclear targeting.

1992 • 104 citations

Transmembrane signaling through B cell MHC class II molecules: anti-Ia antibodies induce protein kinase C translocation to the nuclear fraction.

1987 • 99 citations

FLAP: a novel drug target for inhibiting the synthesis of leukotrienes

1991 • 97 citations

Protein kinase C and phosphatidylserine bind to Mr 110,000/115,000 polypeptides enriched in cytoskeletal and postsynaptic density preparations.

1986 • 95 citations

Identification and Characterization of .alpha.-Protein Kinase C Binding Proteins in Normal and Transformed REF52 Cells

1994 • 91 citations

Protein Kinase C Domains Involved in Interactions with Other Proteins

1994 • 82 citations

Molecular cloning and characterization of the acidic 80-kDa protein kinase C substrate from rat brain. Identification as a glycoprotein.

1991 • 78 citations

Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C.

1994 • 72 citations

Inhibition of protein kinase C function by injection of intracellular receptors for the enzyme

1992 • 55 citations

CaLB: a 43 amino acid calcium-dependent membrane/phospholipid binding domain in p120 Ras GTPase-activating protein.

1995 • 46 citations

Mice sans synaptotagmin

1994 • 38 citations

The regulatory domain of protein kinase C beta 1 contains phosphatidylserine- and phorbol ester-dependent calcium binding activity.

1993 • 29 citations

Translocation of protein kinase C to a Triton-insoluble sub-cellular compartment induced by the lipophilic gold compound auranofin

1988 • 22 citations

Identification of phosphatidylserine-binding proteins in human white blood cells

1990 • 10 citations

Streptolysin O-permeabilized cell system for studyingtrans-acting activities of exogenous nuclear proteins

1993 • 8 citations

Protein Kinase C; current concepts and future perspectives

1993 • 6 citations

Comparison of the methods for determining cell-surface and intracellular receptors for epidermal growth factor in the rat liver.

1991 • 4 citations