Proteinkristallographie und Computer‐Graphik – auf dem Weg zu einer planvollen Arzneimittelentwicklung

Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3Å resolution

1985 • 3,049 citations

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

1983 • 2,839 citations

Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution

1981 • 2,490 citations

Qinghaosu (Artemisinin): an Antimalarial Drug from China

1985 • 2,138 citations

Structure of a human common cold virus and functional relationship to other picornaviruses

1985 • 1,419 citations

Mechanism of activation of a human oncogene

1982 • 1,417 citations

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1982 • 1,398 citations

Chemistry and biology of pteridines

1956 • 1,263 citations

Three-Dimensional Structure of Poliovirus at 2.9 Å Resolution

1985 • 1,253 citations

Three-dimensional structure of calmodulin

1985 • 1,035 citations

Preparation and analysis of protein crystals

1982 • 976 citations

Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids

1977 • 900 citations

Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 Å resolution

1983 • 875 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

The molecular origin of DNA-drug specificity in netropsin and distamycin.

1985 • 800 citations

Diphtheria Toxin

1977 • 780 citations

Human α1-proteinase inhibitor

1984 • 773 citations

The crystal structure of human deoxyhaemoglobin at 1.74 Å resolution

1984 • 738 citations

Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.

1982 • 737 citations

X-ray Diffraction Study of Binding of 2,3-Diphosphoglycerate to Human Deoxyhaemoglobin

1972 • 731 citations

Protein crystallography

1977 • 713 citations

Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change

1982 • 706 citations

Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity

1986 • 671 citations

Structure of the GDP Domain of EF-Tu and Location of the Amino Acids Homologous to ras Oncogene Proteins

1985 • 626 citations

Structure of the calcium regulatory muscle protein troponin-C at 2.8 Å resolution

1985 • 619 citations

Structure of human oxyhaemoglobin at 2·1resolution

1983 • 618 citations

Biological properties of human c-Ha-ras1 genes mutated at codon 12

1984 • 586 citations

Localization of nine glycolytic enzymes in a microbody‐like organelle in Trypanosoma brucei: The glycosome

1977 • 581 citations

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

1983 • 553 citations

Actions of cholera toxin and the prevention and treatment of cholera

1981 • 532 citations

Structure and function of phospholiphase A2

1981 • 478 citations

Molecular Replacement Method

1972 • 468 citations

Structure of thermolysin refined at 1.6 Å resolution

1982 • 443 citations

Structure of bovine pancreatic phospholipase A2 at 1.7 Å resolution

1981 • 429 citations

Binding of an antitumor drug to DNA

1985 • 423 citations

Structure and refinement of penicillopepsin at 1.8 Å resolution

1983 • 405 citations

Bronchoconstrictor Effects of Leukotriene C in Humans

1982 • 404 citations

Biological Macromolecules and Assemblies

1987 • 400 citations

A comparison of the crystal structures of phospholipase A2 from bovine pancreas and Crotalus atrox venom.

1985 • 396 citations

Malignant Activation of a K- ras Oncogene in Lung Carcinoma But Not in Normal Tissue of the Same Patient

1984 • 395 citations

Refined crystal structure of carboxypeptidase a at 1·54 Å resolution

1983 • 391 citations

Predicted nucleotide-binding properties of p21 protein and its cancer-associated variant

1983 • 390 citations

Sequence and structure of yeast phosphoglycerate kinase.

1982 • 364 citations

Molecular Structure of Troponin C from Chicken Skeletal Muscle at 3-Angstrom Resolution

1985 • 342 citations

Amino acid sequence homology between cholera toxin and Escherichia coli heat-labile toxin

1980 • 328 citations

Bacterial toxins: cellular mechanisms of action

1984 • 322 citations

Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.

1985 • 273 citations

Cloning and sequence analysis of cDNA for human renin precursor.

1983 • 266 citations

Refined crystal structure of the potato inhibitor complex of carboxypeptidase A at 2.5 Å resolution

1982 • 260 citations

Penicillin-Sensitive Enzymes in Peptidoglycan Biosynthesis

1984 • 251 citations

An interactive computer graphics study of thermolysin-catalyzed peptide cleavage and inhibition by N-carboxymethyl dipeptides

1984 • 249 citations

A Model for the Tertiary Structure of p21, the Product of the ras Oncogene

1985 • 248 citations

Crystallographic study of the binding of dipeptide inhibitors to thermolysin: implications for the mechanism of catalysis

1977 • 240 citations

Regulation of arachidonic acid production: role of phospholipases C and A2

1982 • 239 citations

Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. II. Environment of bound NADPH and implications for catalysis.

1982 • 234 citations

Structure of porcine pancreatic phospholipase A2 at 2·6resolution and comparison with bovine phospholipase A2

1983 • 233 citations

Crystal structure of avian dihydrofolate reductase containing phenyltriazine and NADPH.

1982 • 219 citations

On the three-dimensional structure and catalytic mechanism of triose phosphate isomerase

1981 • 216 citations

The refined crystal structure of dimeric phospholipase A2 at 2.5 A. Access to a shielded catalytic center.

1985 • 213 citations

Three-dimensional structure, specificity and catalytic mechanism of renin

1983 • 207 citations

Agonist and antagonist properties of calmodulin fragments.

1984 • 198 citations

Preparation and analysis of protein crystals

1983 • 185 citations

Three-dimensional structure of the complex of the Rhizopus chinensis carboxyl proteinase and pepstatin at 2.5 .ANG. resolution

1982 • 185 citations

Activation of a c-K- ras Oncogene by Somatic Mutation in Mouse Lymphomas Induced by Gamma Radiation

1984 • 180 citations

Topogenesis of microbody enzymes: a sequence comparison of the genes for the glycosomal (microbody) and cytosolic phosphoglycerate kinases of Trypanosoma brucei.

1985 • 168 citations

Plasmodium berghei dihydrofolate reductase. Isolation, properties, and inhibition by antifolates.

1969 • 168 citations

The atomic structure of crystalline porcine pancreatic elastase at 2.5 Å resolution: Comparisons with the structure of α-chymotrypsin

1978 • 165 citations

Biological Macromolecules and Assemblies

1985 • 163 citations

EXISTING CHEMOTHERAPY AND ITS LIMITATIONS

1985 • 156 citations

Binding of N-carboxymethyl dipeptide inhibitors to thermolysin determined by x-ray crystallography: a novel class of transition-state analogs for zinc peptidases

1984 • 153 citations

Refined 1.2 A crystal structure of the complex formed between subtilisin Carlsberg and the inhibitor eglin c. Molecular structure of eglin and its detailed interaction with subtilisin.

1986 • 147 citations

A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa

1984 • 145 citations

Dihydrofolate reductase. The stereochemistry of inhibitor selectivity.

1985 • 139 citations

Primary structure of heat-labile enterotoxin produced by Escherichia coli pathogenic for humans.

1984 • 139 citations

Bacterial toxins: cellular mechanisms of action.

1984 • 135 citations

Tertiary structural similarity between a class A β-lactamase and a penicillin-sensitive D-alanyl carboxypeptidase-transpeptidase

1986 • 134 citations

Homology between human bladder carcinoma oncogene product and mitochondrial ATP-synthase

1983 • 131 citations

Dihydrofolate reductase: thymidylate synthase, a bifunctional polypeptide from Crithidia fasciculata.

1980 • 130 citations

2:4‐DIAMINOPYRIMIDINES—A NEW SERIES OF ANTIMALARIALS

1951 • 129 citations

Refined crystal structure of deoxyhemoglobin S. II. Molecular interactions in the crystal.

1985 • 129 citations

Simultaneous purification of hexokinase, class-I fructose-bisphosphate aldolase, triosephosphate isomerase and phosphoglycerate kinase from Trypanosoma brucei

1984 • 126 citations

Structure of a Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase at 2.5 Å resolution

1982 • 123 citations

COMPOUNDS DESIGNED TO FIT A SITE OF KNOWN STRUCTURE IN HUMAN HAEMOGLOBIN

1976 • 120 citations

Homology among acid proteases: comparison of crystal structures at 3A resolution of acid proteases from Rhizopus chinensis and Endothia parasitica.

1977 • 119 citations

Substituted benzaldehydes designed to increase the oxygen affinity of human haemoglobin and inhibit the sickling of sickle erythrocytes

1984 • 118 citations

Computer graphics modelling of human renin

1984 • 114 citations

Spontaneous activation of a human proto-oncogene.

1983 • 114 citations

Structure and regulated expression of genes encoding fructose biphosphate aldolase in Trypanosoma brucei.

1985 • 110 citations

Development of antisickling compounds that chemically modify hemoglobin S specifically within the 2,3-diphosphoglycerate binding site

1980 • 109 citations

Primary Structure of Cholera Toxin β-Chain: A Glycoprotein Hormone Analog?

1977 • 106 citations

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs

1985 • 105 citations

Escherichia coli heat-labile enterotoxin. Nucleotide sequence of the A subunit gene.

1982 • 104 citations

BIOCHEMICAL PECULIARITIES OF TRYPANOSOMES, AFRICAN AND SOUTH AMERICAN

1985 • 101 citations

New approach to screening drugs for activity against African trypanosomes

1977 • 101 citations

Chemistry and biochemistry of folates

1984 • 100 citations

Refined crystal structure of deoxyhemoglobin S. I. Restrained least-squares refinement at 3.0-A resolution.

1985 • 96 citations

Crystal and molecular structure of the inhibitor eglin from leeches in complex with subtilisin Carlsberg

1985 • 96 citations

Drug design by the method of receptor fit

1984 • 95 citations

Determination of the primary structure of cholera toxin B subunit.

1977 • 95 citations

Refined crystal structure of deoxyhemoglobin S. I. Restrained least-squares refinement at 3.0-A resolution.

1985 • 93 citations

Phosphoglycerate kinase

1981 • 90 citations

2.8-A Structure of penicillin-sensitive D-alanyl carboxypeptidase-transpeptidase from Streptomyces R61 and complexes with beta-lactams.

1985 • 87 citations

Penicillin Target Enzyme and the Antibiotic Binding Site

1982 • 81 citations

Role of the N-terminus in the interaction of pancreatic phospholipase A2 with aggregated substrates. Properties and crystal structure of transaminated phospholipase A2

1984 • 81 citations

Physiological and x-ray studies of potential antisickling agents.

1983 • 80 citations

Molecular cloning and nucleotide sequence of a human renin cDNA fragment

1983 • 79 citations

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs

1982 • 79 citations

Biochemistry of the Variant Surface Glycoproteins of Salivarian Trypanosomes

1982 • 77 citations

Prediction of the three-dimensional structure of the transforming region of the EJ/T24 human bladder oncogene product and its normal cellular homologue.

1983 • 75 citations

Structure of a mercaptan-thermolysin complex illustrates mode of inhibition of zinc proteases by substrate-analog mercaptans

1982 • 67 citations

Crystallographic study of the binding of a trifluoroacetyl dipeptide anilide inhibitor with elastase

1982 • 59 citations

The Leukotrienes in Allergy and Inflammation

1982 • 58 citations

6 Å-Resolution X-ray structure of a variable surface glycoprotein from Trypanosoma brucei

1984 • 58 citations

Speech Recognition by Computer

1981 • 56 citations

Chandler Wobble, earthquakes, rotation, and geomagnetic changes

1975 • 54 citations

Localization of a trifluoperazine binding site on troponin C

1983 • 53 citations

The Beta-Lactam Antibiotics

1981 • 51 citations

X-ray grade crystals of diphtheria toxin.

1982 • 50 citations

The structure of bovine pancreatic prophospholipase A2 at 3.0 Å resolution

1982 • 50 citations

Glucocorticoids, phospholipase A2 and inflammation

1981 • 48 citations

A proton NMR study of the interactions and conformations of rationally designed brodimoprim analogs in complexes with Lactobacillus casei dihydrofolate reductase

1984 • 43 citations

Immunochemical relatedness between secretory phospholipase A2 and intracellular·phospholipase A2

1985 • 39 citations

Dihydrofolate reductases within the genus Trypanosoma

1969 • 37 citations

Cholera Toxin Crystals Suitable for X-ray Diffraction

1977 • 35 citations

Cholera toxin

1982 • 33 citations

Catalytic conformation of carboxypeptidase A

1983 • 33 citations

Crystallographic studies on apocarboxypeptidase A and the complex with glycyl-L-tyrosine.

1983 • 33 citations

Heat-labile enterotoxin of Escherichia coli. Characterization of different crystal forms.

1985 • 32 citations

Design of inhibitors from the three-dimensional structure of alcohol dehydrogenase. Chemical synthesis and enzymic properties

1984 • 31 citations

The use of phase combination in the refinement of phosphoglycerate kinase at 2.5 Å resolution

1981 • 30 citations

Heat-labile enterotoxin of Escherichia coli. Characterization of different crystal forms.

1985 • 28 citations

Preliminary crystallographic studies of triosephosphate isomerase from the blood parasite Trypanosoma brucei brucei

1984 • 23 citations

Preliminary X-ray crystallographic data on mouse submaxillary gland renin and renin-inhibitor complexes.

1984 • 22 citations

Malaria: Resurgence in Research Brightens Prospects

1977 • 17 citations

ChemInform Abstract: A PROTON NMR STUDY OF THE INTERACTIONS AND CONFORMATIONS OF RATIONALLY DESIGNED BRODIMOPRIM ANALOGS IN COMPLEXES WITH LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE

1985 • 6 citations

Species-specific irreversible inhibition of Neisseria gonorrhoeae dihydrofolate reductase by a substituted 2,4-diamino-5-benzylpyrimidine.

1984 • 4 citations