The atomic structure of crystalline porcine pancreatic elastase at 2.5 Å resolution: Comparisons with the structure of α-chymotrypsin

A semi-empirical method of absorption correction

1968 • 7,409 citations

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units

1968 • 1,497 citations

Role of a Buried Acid Group in the Mechanism of Action of Chymotrypsin

1969 • 1,060 citations

Structure of crystalline α-chymotrypsin

1972 • 675 citations

Three-dimensional Structure of Tosyl-α-chymotrypsin

1967 • 609 citations

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor

1974 • 548 citations

Real-space refinement of the structure of hen egg-white lysozyme

1974 • 516 citations

The treatment of errors in the isomorphous replacement method

1959 • 497 citations

Conformation of twisted β-pleated sheets in proteins

1973 • 487 citations

The refined crystal structure of bovine β-trypsin at 1·8 Å resolution

1975 • 462 citations

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor

1973 • 449 citations

Refinement of protein conformations using a macromolecular energy minimization procedure

1969 • 444 citations

Structure of crystalline α-chymotrypsin

1968 • 435 citations

IUPAC-IUB Commission on Biochemical Nomenclature

1970 • 414 citations

Subtilisin. Stereochemical mechanism involving transition-state stabilization

1972 • 376 citations

Structure of crystalline α-chymotrypsin

1969 • 374 citations

Structure of crystalline α-chymotrypsin

1970 • 344 citations

The structure of thermolysin: An electron density map at 2.3 Å resolution

1972 • 315 citations

The matching of physical models to three-dimensional electron-density maps: A simple optical device

1968 • 313 citations

Structure and function of haemoglobin

1968 • 302 citations

Three-dimensional Structure of Tosyl-elastase

1970 • 299 citations

The structure of bovine trypsin : Electron density maps of the inhibited enzyme at 5 Å and at 2·7 Å resolution

1974 • 279 citations

Terbium(III) emission as a probe of calcium(II) binding sites in proteins

1976 • 255 citations

Conformational equilibria in α- and δ-chymotrypsin

1972 • 250 citations

Structure and function of haemoglobin

1967 • 242 citations

Carbon nuclear magnetic resonance studies of the histidine residue in α-lytic protease. Implications for the catalytic mechanism of serine proteases

1973 • 239 citations

Homologies in serine proteinases

1970 • 239 citations

Energy refinement of hen egg-white lysozyme

1974 • 233 citations

A real-space refinement procedure for proteins

1971 • 233 citations

Amino-acid Sequence of Porcine Pancreatic Elastase and its Homologies with other Serine Proteinases

1970 • 219 citations

The crystal structure of myoglobin: Phase determination to a resolution of 2 Å by the method of isomorphous replacement

1961 • 207 citations

Structure and specific binding of trypsin: Comparison of inhibited derivatives and a model for substrate binding

1974 • 199 citations

Implication of an Ionizing Group in the Control of Conformation and Activity of Chymotrypsin

1966 • 193 citations

Stereochemical Criteria for Polypeptide and Protein Chain Conformations

1966 • 183 citations

A mathematical model-building procedure for proteins

1966 • 183 citations

Substrate binding site in bovine chymotrypsin A_γ. Crystallographic study using peptide chloromethyl ketones as site-specific inhibitors

1971 • 181 citations

Energy functions for peptides and proteins. II. Amide hydrogen bond and calculation of amide crystal properties

1974 • 174 citations

A mathematical procedure for superimposing atomic coordinates of proteins

1972 • 158 citations

Equilibrium and rate constants for the interconversion of two conformations of α-chymotrypsin

1971 • 150 citations

Three-dimensional Fourier Synthesis of Tosyl-elastase at 3.5 Å Resolution

1970 • 144 citations

The combination of isomorphous replacement and anomalous scattering data in phase determination of non-centrosymmetric reflexions

1965 • 140 citations

Tertiary structural differences between microbial serine proteases and pancreatic serine enzymes

1975 • 132 citations

[7] Elastase

1970 • 125 citations

Acetyl-<scp>L</scp>-alanyl-<scp>L</scp>-alanyl-<scp>L</scp>-alanine methyl ester: a new highly specific elastase substrate

1970 • 120 citations

The single calcium‐binding site of crystalline bovine β‐trypsin

1975 • 112 citations

Competitive labelling, a method for determining the reactivity of individual groups in proteins. The amino groups of porcine elastase

1971 • 111 citations

Dependence of the kinetic parameters for elastase-catalyzed amide hydrolysis on the length of peptide substrates

1973 • 110 citations

A model for the association of bovine pancreatic trypsin inhibitor with chymotrypsin and trypsin

1972 • 107 citations

The charge relay system in chymotrypsin and chymotrypsinogen

1973 • 104 citations

Atomic CO-ordinates for tosyl-α-chymotrypsin

1969 • 104 citations

The structure of carboxypeptidase A

1966 • 101 citations

I. Serine proteinases. The structure of α-chymotrypsin

1970 • 92 citations

Proteolysis and Physiological Regulation

1976 • 89 citations

Active-site specific inhibitors of elastase

1973 • 88 citations

Restrictions on the binding of proline-containing peptides to elastase

1973 • 87 citations

Proteolysis of elastin-ligand complexes. Stimulation of elastase digestion of insoluble elastin by sodium dodecyl sulfate

1972 • 85 citations

Variability in the tertiary structure of α-chymotrypsin at 2.8-Å resolution

1973 • 84 citations

The refined crystal structure of bovine β-trypsin at 1·8 Å resolution

1975 • 83 citations

Primary Structure of α-Lytic Protease: a Bacterial Homologue of the Pancreatic Serine Proteases

1970 • 83 citations

Difference Fourier refinement of the structure of DIP-trypsin at 1.5 Å with a minicomputer technique

1977 • 74 citations

The Involvement of the Amino-terminal Amino Acid in the Activity of Pancreatic Proteases

1967 • 68 citations

Comparison of homologous tertiary structures of proteins

1974 • 65 citations

Comparison of the crystal structures of chymotrypsinogen-A and α-chymotrypsin

1973 • 64 citations

Relation of the α-amino group of trypsin to enzyme function and zymogen activation

1973 • 64 citations

On the active site of elastase: Partial mapping by means of specific peptide substrates

1970 • 61 citations

Isolation and Characterization of Porcine Proelastase

1970 • 56 citations

Evidence for the amino acid sequence of porcine pancreatic elastase

1973 • 55 citations

Peptide chloromethyl ketones as irreversible inhibitors of elastase

1973 • 54 citations

Changes in the tertiary structure of .alpha.-chymotrypsin with change in pH. The pH 4.2-6.7

1973 • 54 citations

Evidence that the activity of elastase is not dependent on the ionization of its N-terminal amino group

1969 • 48 citations

Content of ATP and ADP in Rabbit Blastocysts

1971 • 47 citations

The active site of porcine elastase

1975 • 41 citations

Binding interactions between two ligands and a monomeric protein

1970 • 40 citations

The three-dimensional structure of crystalline porcine pancreatic elastase

1970 • 40 citations

Activity and conformation of the alkaline form of δ-chymotrypsin studied by the specific acylation of isoleucine-16

1970 • 38 citations

Selective, Reversible Loss of Elastolytic Activity of Elastase and Subtilisin Resulting from Electrostatic Changes Due to Maleylation

1971 • 38 citations

Active-site specific inhibitors of elastase

1972 • 37 citations

The structure of α-chymotrypsin. I. The refinement of the heavy-atom isomorphous derivatives at 2.8 Å resolution

1973 • 36 citations

Activation of chymotrypsinogen-A

1973 • 34 citations

Chemical and crystallographic study of carbamoyl-chymotrypsin A

1972 • 34 citations

Specificity of elastase. Hydrolysis of peptide p-nitrobenzyl esters

1972 • 33 citations

The Involvement of the Amino-terminal Amino Acid in the Activity of Pancreatic Proteases

1967 • 32 citations

Crystalline porcine pancreatic elastase

1968 • 29 citations

Kinetics of the Reaction of Nitrous Acid with Model Compounds and Proteins, and the Conformational State of N-terminal Groups in the Chymotrypsin Family

1972 • 29 citations

Elastase-catalyzed amide hydrolysis of triand tetrapeptide amides

1973 • 27 citations

An X-ray crystallographic investigation of exchange of localized sulfate ions in crystals of α-chymotrypsin

1973 • 24 citations

Size and stereospecificity of the active site of porcine elastase

1973 • 18 citations

Atomic coordinates for tosyl-elastase

1973 • 16 citations

A device for the rapid measurement of molecular model co-ordinates for X-ray crystallography

1972 • 15 citations

The role of tyrosines in elastase

1972 • 15 citations

Reaction of acetic and maleic anhydrides with elastase. Evidence for a role of the amino-terminal valine

1974 • 13 citations

The Carboxyl-Terminal Amino Acid Sequence of Streptomyces griseus Protease A

1972 • 9 citations

The Active Site of Pancreatic Porcine Elastase: Specificity, Size and Stereospecificity

1974 • 6 citations