Malignant Activation of a K- ras Oncogene in Lung Carcinoma But Not in Normal Tissue of the Same Patient

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A new method for sequencing DNA.

1977 • 7,941 citations

Mechanism of activation of a human oncogene

1982 • 1,417 citations

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1982 • 1,398 citations

Changes in size and secondary structure of the ribosomal transcription unit during vertebrate evolution

1975 • 1,188 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

1982 • 928 citations

Isolation of a transforming sequence from a human bladder carcinoma cell line

1982 • 776 citations

Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.

1982 • 775 citations

The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes

1981 • 736 citations

Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change

1982 • 706 citations

Cellular Transforming Genes

1982 • 622 citations

T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes

1982 • 617 citations

Suppression of Malignancy by Cell Fusion

1969 • 613 citations

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

1983 • 553 citations

Structure and activation of the human N-ras gene

1983 • 538 citations

Detection of sickle cell beta S-globin allele by hybridization with synthetic oligonucleotides.

1983 • 536 citations

Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells

1982 • 494 citations

Oncogenes in solid human tumours

1982 • 467 citations

Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1

1983 • 441 citations

Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene

1983 • 385 citations

Three human transforming genes are related to the viral ras oncogenes.

1983 • 379 citations

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1

1983 • 377 citations

Human Cell Hybrids: Analysis of Transformation and Tumorigenicity

1982 • 349 citations

Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line.

1983 • 290 citations

Nucleotide Sequence of the Oncogene Encoding the p21 Transforming Protein of Kirsten Murine Sarcoma Virus

1982 • 256 citations

Positive cooperativity of the estrogen receptor.

1981 • 173 citations

Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype.

1983 • 172 citations

Mutation Affecting the 12th Amino Acid of the c-Ha- ras Oncogene Product Occurs Infrequently in Human Cancer

1983 • 162 citations

p21 of Kirsten murine sarcoma virus is thermolabile in a viral mutant temperature sensitive for the maintenance of transformation

1979 • 150 citations

Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.

1984 • 132 citations

Spontaneous activation of a human proto-oncogene.

1983 • 114 citations

Generation of BALB-MuSV and Ha-MuSV by type C virus transduction of homologous transforming genes from different species

1981 • 86 citations