Mining gene expression profiles: expression signatures as cancer phenotypes

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

2005 • 44,461 citations

The Hallmarks of Cancer

2000 • 27,569 citations

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

Molecular portraits of human breast tumours

2000 • 15,445 citations

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

1999 • 11,586 citations

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

2000 • 9,712 citations

MicroRNA expression profiles classify human cancers

2005 • 9,457 citations

Gene expression profiling predicts clinical outcome of breast cancer

2002 • 9,314 citations

MicroRNA signatures in human cancers

2006 • 7,358 citations

A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

2002 • 6,428 citations

A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer

2004 • 5,895 citations

A microRNA expression signature of human solid tumors defines cancer gene targets

2006 • 5,638 citations

Repeated observation of breast tumor subtypes in independent gene expression data sets

2003 • 5,356 citations

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

2006 • 4,789 citations

MicroRNA Gene Expression Deregulation in Human Breast Cancer

2005 • 4,014 citations

A microRNA polycistron as a potential human oncogene

2005 • 3,482 citations

The Consensus Coding Sequences of Human Breast and Colorectal Cancers

2006 • 3,040 citations

Unique microRNA molecular profiles in lung cancer diagnosis and prognosis

2006 • 3,029 citations

Patterns of somatic mutation in human cancer genomes

2007 • 2,975 citations

Gene expression correlates of clinical prostate cancer behavior

2002 • 2,504 citations

A molecular signature of metastasis in primary solid tumors

2002 • 2,424 citations

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

2002 • 2,400 citations

Prediction of central nervous system embryonal tumour outcome based on gene expression

2002 • 2,359 citations

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

2006 • 2,130 citations

Multiclass cancer diagnosis using tumor gene expression signatures

2001 • 2,021 citations

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

2005 • 2,015 citations

Gene-expression profiles predict survival of patients with lung adenocarcinoma

2002 • 2,005 citations

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

2005 • 1,478 citations

Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells

2004 • 1,395 citations

Concordance among Gene-Expression–Based Predictors for Breast Cancer

2006 • 1,336 citations

Predicting the clinical status of human breast cancer by using gene expression profiles

2001 • 1,336 citations

BRAF mutation predicts sensitivity to MEK inhibition

2005 • 1,312 citations

Gene expression profiling identifies clinically relevant subtypes of prostate cancer

2004 • 1,292 citations

A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers

2006 • 1,135 citations

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

2002 • 1,112 citations

Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression

2004 • 1,025 citations

Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival

2005 • 956 citations

Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds

2004 • 931 citations

Molecular Diagnosis of Burkitt's Lymphoma

2006 • 909 citations

Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer

2003 • 889 citations

Outcome signature genes in breast cancer: is there a unique set?

2004 • 798 citations

A module map showing conditional activity of expression modules in cancer

2004 • 693 citations

Chemosensitivity prediction by transcriptional profiling

2001 • 673 citations

Gene expression predictors of breast cancer outcomes

2003 • 631 citations

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

2006 • 596 citations

Genomic signatures to guide the use of chemotherapeutics

2006 • 596 citations

A Genomic Strategy to Refine Prognosis in Early-Stage Non–Small-Cell Lung Cancer

2006 • 573 citations

Mutations in a signalling pathway

2005 • 551 citations

Gene Expression Profiles Predict Complete Pathologic Response to Neoadjuvant Paclitaxel and Fluorouracil, Doxorubicin, and Cyclophosphamide Chemotherapy in Breast Cancer

2004 • 545 citations

Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance

2006 • 512 citations

Integrative analysis of the cancer transcriptome

2005 • 494 citations

Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer

2005 • 469 citations

A Mechanism of Cyclin D1 Action Encoded in the Patterns of Gene Expression in Human Cancer

2003 • 421 citations

An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis

2004 • 420 citations

Gene Duplication: The Genomic Trade in Spare Parts

2004 • 357 citations

Identification of Candidate Molecular Markers Predicting Sensitivity in Solid Tumors to Dasatinib: Rationale for Patient Selection

2007 • 338 citations

Gene Expression Profiling Reveals Reproducible Human Lung Adenocarcinoma Subtypes in Multiple Independent Patient Cohorts

2006 • 287 citations

An Integrated Genomic-Based Approach to Individualized Treatment of Patients With Advanced-Stage Ovarian Cancer

2007 • 286 citations

Gene expression phenotypic models that predict the activity of oncogenic pathways

2003 • 264 citations

Patterns of Gene Expression That Characterize Long-term Survival in Advanced Stage Serous Ovarian Cancers

2005 • 262 citations

Genetic regulators of large-scale transcriptional signatures in cancer

2006 • 222 citations

Integrated modeling of clinical and gene expression information for personalized prediction of disease outcomes

2004 • 220 citations

Initiating oncogenic event determines gene-expression patterns of human breast cancer models

2002 • 199 citations

Mining for regulatory programs in the cancer transcriptome

2005 • 170 citations

Baseline Gene Expression Predicts Sensitivity to Gefitinib in Non–Small Cell Lung Cancer Cell Lines

2006 • 139 citations

Gene expression patterns that predict sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer cell lines and human lung tumors

2006 • 76 citations

Distinct gene expression phenotypes of cells lacking Rb and Rb family members.

2003 • 72 citations

At the crossroads of inflammation and cancer

2004 • 4 citations

Deleted Work

1955 • 0 citations