An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis

Statistical Learning Theory

1999 • 27,709 citations

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

1999 • 11,586 citations

The detection of disease clustering and a generalized regression approach.

1967 • 11,489 citations

In silico prediction of protein-protein interactions in human macrophages

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Significance analysis of microarrays applied to the ionizing radiation response

2001 • 10,393 citations

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

2004 • 9,201 citations

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

2003 • 8,996 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

2001 • 2,560 citations

A molecular signature of metastasis in primary solid tumors

2002 • 2,424 citations

Multiclass cancer diagnosis using tumor gene expression signatures

2001 • 2,021 citations

Gene-expression profiles predict survival of patients with lung adenocarcinoma

2002 • 2,005 citations

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

2001 • 1,672 citations

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

2003 • 1,515 citations

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

2001 • 1,145 citations

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

2002 • 1,112 citations

Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds

2004 • 931 citations

Myc-driven murine prostate cancer shares molecular features with human prostate tumors

2003 • 787 citations

Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects

2004 • 780 citations

Classification of pediatric acute lymphoblastic leukemia by gene expression profiling

2003 • 598 citations

Exploration of Global Gene Expression Patterns in Pancreatic Adenocarcinoma Using cDNA Microarrays

2003 • 475 citations

A Mechanism of Cyclin D1 Action Encoded in the Patterns of Gene Expression in Human Cancer

2003 • 421 citations

The Dual Specificity Phosphatases M3/6 and MKP-3 Are Highly Selective for Inactivation of Distinct Mitogen-activated Protein Kinases

1996 • 385 citations

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

1997 • 359 citations

Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis?

2004 • 299 citations

A genome-wide survey of RAS transformation targets

2000 • 293 citations

Missense mutations of the BRAF gene in human lung adenocarcinoma.

2002 • 283 citations

Gene expression phenotypic models that predict the activity of oncogenic pathways

2003 • 264 citations

MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb

2003 • 257 citations

Initiating oncogenic event determines gene-expression patterns of human breast cancer models

2002 • 199 citations

Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF

2001 • 174 citations

Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas

2003 • 95 citations

Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells

2004 • 78 citations

TDAG51 Mediates the Effects of Insulin-like Growth Factor I (IGF-I) on Cell Survival

2004 • 77 citations

Induction of the mitogen‐activated protein kinase phosphatase MKP3 by nerve growth factor in differentiating PC12

1998 • 71 citations