TSG-6: An IL-1 /TNF-inducible protein with anti-inflammatory activity

Novel Regulators of Bone Formation: Molecular Clones and Activities

1988 • 3,919 citations

The acute phase response

1994 • 2,927 citations

Cell Biology of Extracellular Matrix

1988 • 1,498 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

Angiogenesis Induced by Degradation Products of Hyaluronic Acid

1985 • 1,128 citations

Physiological consequences of loss of plasminogen activator gene function in mice

1994 • 1,051 citations

Cell biology of extracellular matrix

1992 • 1,042 citations

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.

1989 • 914 citations

Cell-Associated Plasminogen Activation: Regulation and Physiological Functions

1988 • 826 citations

A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase.

1985 • 731 citations

A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family

1989 • 680 citations

The Immunoglobulin Fold

1994 • 679 citations

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

1993 • 658 citations

Hyaluronan‐binding proteins in development, tissue homeostasis, and disease

1993 • 656 citations

Basic and clinical aspects of fibrinolysis and thrombolysis

1991 • 653 citations

Multiple domains of the large fibroblast proteoglycan, versican.

1989 • 646 citations

Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function

1996 • 639 citations

Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.

1990 • 624 citations

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

1989 • 579 citations

Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol

1991 • 578 citations

A human lymphocyte homing receptor, the Hermes antigen, is related to cartilage proteoglycan core and link proteins

1989 • 568 citations

The CUB Domain

1993 • 564 citations

Role of cell-surface lysines in plasminogen binding to cells: identification of .alpha.-enolase as a candidate plasminogen receptor

1991 • 544 citations

Bone Morphogenetic Protein-1: The Type I Procollagen C-Proteinase

1996 • 513 citations

The formation of a structure with the features of synovial lining by subcutaneous injection of air: An in vivo tissue culture system

1981 • 479 citations

The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type.

1986 • 466 citations

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.

1990 • 449 citations

The cell biology of the plasminogen system

1995 • 424 citations

Hyaluronan and its binding proteins, the hyaladherins

1990 • 419 citations

Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility

1992 • 396 citations

Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein.

1994 • 384 citations

Identification of hyaluronic acid binding sites in the extracellular domain of CD44

1993 • 370 citations

Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA clones.

1987 • 367 citations

Involvement of endogenous tumor necrosis factor alpha and transforming growth factor beta during induction of collagen type II arthritis in mice.

1992 • 363 citations

IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro.

1990 • 361 citations

Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis

1988 • 354 citations

Structural biochemistry and activation of matrix metalloproteases

1993 • 347 citations

Plasminogen Activation Initiated by Single-chain Urokinase-type Plasminogen Activator

1989 • 341 citations

Hyaluronate binding properties of versican.

1992 • 319 citations

Degradation of connective tissue matrices by macrophages. I. Proteolysis of elastin, glycoproteins, and collagen by proteinases isolated from macrophages.

1980 • 314 citations

Solution Structure of the Link Module: A Hyaluronan-Binding Domain Involved in Extracellular Matrix Stability and Cell Migration

1996 • 313 citations

A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.

1992 • 295 citations

Proteoglycans and Hyaluronan in Morphogenesis and Differentiation

1991 • 284 citations

Anti-CD44 treatment abrogates tissue aedema and leukocyte infiltration in murine arthrtis

1995 • 283 citations

The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants.

1990 • 278 citations

Extracellular Matrix Degradation

1991 • 262 citations

The inter-α-inhibitor family: from structure to regulation

1996 • 249 citations

Hyaluronate and invasiveness of the rabbit V2 carcinoma.

1979 • 241 citations

DETECTION OF CYTOKINES AT THE CARTILAGE/PANNUS JUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS: IMPLICATIONS FOR THE ROLE OF CYTOKINES IN CARTILAGE DESTRUCTION AND REPAIR

1992 • 233 citations

Modulation of IL-1-induced neutrophil migration by dexamethasone and lipocortin 1.

1993 • 223 citations

The Biology of hyaluronan

1989 • 222 citations

TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo.

1996 • 214 citations

Interactions between human tumor cells and fibroblasts stimulate hyaluronate synthesis.

1984 • 203 citations

Hyaluronan and a cell-associated hyaluronan binding protein regulate the locomotion of ras-transformed cells.

1991 • 198 citations

Beneficial actions of exogenous hyaluronic acid on wound healing.

1991 • 195 citations

Secretion of basement membrane collagen degrading enzyme and plasminogen activator by transformed cells – role in metastasis

1982 • 195 citations

The plasminogen-plasmin system in malignancy

1992 • 190 citations

Analysis of Inter-α-trypsin Inhibitor and a Novel Trypsin Inhibitor, Pre-α-trypsin Inhibitor, from Human Plasma

1989 • 183 citations

Low levels of interleukin‐4 and high levels of transforming growth factor β in rheumatoid synovitis

1990 • 181 citations

Cytokines and proteases in invasive processes: Molecular similarities between inflammation and cancer

1992 • 160 citations

Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor.

1991 • 159 citations

Isolation and characterization of eight tumor necrosis factor-induced gene sequences from human fibroblasts.

1990 • 158 citations

Tumor-associated hyaluronan. Providing an extracellular matrix that facilitates invasion.

1996 • 154 citations

TSG-6: a TNF-, IL-1-, and LPS-inducible secreted glycoprotein associated with arthritis.

1993 • 150 citations

Cartilage proteoglycans. Assembly with hyaluronate and link protein as studied by electron microscopy

1988 • 148 citations

Tumor invasion: A consequence of destructive and compositional matrix alterations

1988 • 146 citations

Tumor necrosis factors — structure, function and mechanism of action

1992 • 143 citations

Inhibition of cell surface receptor-bound plasmin by alpha 2-antiplasmin and alpha 2-macroglobulin

1991 • 143 citations

Physiological mechanisms for metalloproteinase activation.

1992 • 142 citations

The tandemly repeated sequences of cartilage link protein contain the sites for interaction with hyaluronic acid.

1987 • 136 citations

TGF-beta 1 stimulation of cell locomotion utilizes the hyaluronan receptor RHAMM and hyaluronan.

1993 • 131 citations

Transforming growth factor-beta and cellular immune responses in synovial fluids.

1990 • 129 citations

Tumor-Associated Urokinase-Type Plasminogen Activator: Biological and Clinical Significance

1992 • 122 citations

Identification of the rat Heymann nephritis autoantigen (GP330) as a receptor site for plasminogen

1991 • 119 citations

An Elisa Plate Based Assay for Hyaluronan Using Biotinylated Proteoglycan G1 Domain (HA-Binding Region)

1990 • 118 citations

Mechanisms and Models in Rheumatoid Arthritis

1995 • 113 citations

Isolation and biochemical characterization of heparin‐binding proteins from boar seminal plasma: A dual role for spermadhesins in fertilization

1993 • 113 citations

Secondary Structures in Hyaluronan Solutions: Chemical and Biological Implications

2007 • 111 citations

Interaction of single-chain urokinase-type plasminogen activator with human endothelial cells.

1990 • 109 citations

Link protein is ubiquitously expressed in non-cartilaginous tissues where it enhances and stabilizes the interaction of proteoglycans with hyaluronic acid.

1994 • 104 citations

TSG-6, an Arthritis-Associated Hyaluronan Binding Protein, Forms a Stable Complex with the Serum Protein Inter-.alpha.-inhibitor

1994 • 102 citations

Hyaluronan-Mediated Aggregation of Limb Bud Mesenchyme and Mesenchymal Condensation during Chondrogenesis

1996 • 99 citations

Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin.

1993 • 97 citations

Boar Spermadhesin AWN-1. Oligosaccharide and Zona Pellucida Binding Characteristics

1995 • 96 citations

Inter-α-trypsin Inhibitor

1989 • 96 citations

An inter-alpha trypsin inhibitor of human serum

1965 • 88 citations

PATHOPHYSIOLOGICAL INTERPRETATION OF KINETIC CONSTANTS OF PROTEASE INHIBITORS

1981 • 87 citations

Link protein cDNA sequence reveals a tandemly repeated protein structure.

1986 • 84 citations

Characterization of human endothelial cell urokinase-type plasminogen activator receptor protein and messenger RNA

1990 • 84 citations

NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1.

1994 • 82 citations

Boar Spermadhesin AWN-1. Oligosaccharide and Zona Pellucida Binding Characteristics

1995 • 79 citations

Human inter-α-inhibitor family in inflammation: simultaneous synthesis of positive and negative acute-phase proteins

1993 • 77 citations

Gene Targeting and Gene Transfer Studies of the Biological Role of the Plasminogen/Plasmin System

1995 • 73 citations

Carbohydrate as covalent crosslink in human inter‐α‐trypsin inhibitor: A novel plasma protein structure

1988 • 73 citations

EFFECT OF PROTEASE INHIBITOR ON ISCHEMIA/REPERFUSION INJURY OF THE RAT LIVER

1993 • 72 citations

Stimulation of glycosaminoglycan synthesis in cultured human dermal fibroblasts by interleukin 1. Induction of hyaluronic acid synthesis by natural and recombinant interleukin 1s and synthetic interleukin 1 beta peptide 163-171.

1989 • 68 citations

Stimulation of the hyaluronic acid levels of human synovial fibroblasts by recombinant human tumor necrosis factor α, tumor necrosis factor β (lymphotoxin), interleukin‐1α, and interleukin‐1β

1988 • 68 citations

Boar spermadhesins AQN‐1 and AWN are sperm‐associated acrosin inhibitor acceptor proteins

1992 • 63 citations

Binding of haptoglobin, inter-alpha-trypsin inhibitor, and alpha 1 proteinase inhibitor to synovial fluid hyaluronate and the influence of these proteins on its degradation by oxygen derived free radicals.

1988 • 61 citations

Proteinases and inhibitors

1995 • 61 citations

Tumor necrosis factor: molecular and cellular biology and clinical relevance

1994 • 59 citations

Transcriptional regulation of TSG6, a tumor necrosis factor- and interleukin-1-inducible primary response gene coding for a secreted hyaluronan-binding protein.

1993 • 58 citations

Two out of the three kinds of subunits of inter‐α‐trypsin inhibitor are structurally related

1989 • 56 citations

Activation of human neutrophil gelatinase by endogenous serine proteinases

1988 • 54 citations

Correlation between increased hyaluronan localized in arthritic synovium and the presence of proliferating cells. A role for macrophage‐derived factors

1992 • 53 citations

Kinetic analysis of the effects of heparin and lipoproteins on tissue plasminogen activator mediated plasminogen activation

1990 • 51 citations

Stracture of inter-α-inhibitor (inter-α-trypsin inhibitor) and pre-α-inhibitor: current state and proposition of a new terminology

1990 • 51 citations

Characterization of the plasminogen receptors of normal and rheumatoid arthritis human synovial fibroblasts.

1994 • 51 citations

TNF signal transduction and TNF-responsive genes.

1992 • 51 citations

Isolation of an α2-Globulin from Human Plasma

1961 • 50 citations

Cellular Biology of Cartilage Degradation

1995 • 49 citations

TSG‐6 expression in human articular chondrocytes: Possible implications in joint inflammation and cartilage degradation

1996 • 47 citations

A Proteoglycan Related to the Urinary Trypsin Inhibitor (UTI) Links the two Heavy Chains of Inter-α-Trypsin Inhibitor

1989 • 46 citations

Tumor necrosis factor: Molecular and cellular biology and clinical relevance

1995 • 45 citations

Proteinase inhibitors in rheumatoid arthritis.

1975 • 45 citations

Structural analysis of the uEGF gene in the sea urchinStrongylocentrotus purpuratus reveals more similarity to vertebrate than to invertebrate genes with EGF-like repeats

1989 • 44 citations

Characterization of AWN‐1 glycosylated isoforms helps define the zona pellucida and serine proteinase inhibitor‐binding region on boar spermadhesins

1993 • 44 citations

In vivoBinding of Human Inter-α-Trypsin Inhibitor Free Heavy Chains to Hyaluronic Acid

1994 • 41 citations

Morphological localization of hyaluronan in normal and diseased synovium.

1991 • 39 citations

The expression of functional link protein in a baculovirus system: analysis of mutants lacking the A, B and B' domains

1994 • 37 citations

Structure of inter-alpha-inhibitor (inter-alpha-trypsin inhibitor) and pre-alpha-inhibitor: current state and proposition of a new terminology.

1990 • 36 citations

Cartilage degradation by cocultures of transformed macrophage and fibroblast cell lines. A model of metalloproteinase-mediated connective tissue degradation.

1993 • 36 citations

Mapping the heparin‐binding domain of boar spermadhesins

1996 • 34 citations

Molecular cloning of a mammalian hyaluronidase reveals identity with hemopexin, a serum heme-binding protein.

1994 • 34 citations

Kinetic analysis of the effects of glycosaminoglycans and lipoproteins on urokinase-mediated plasminogen activation

1991 • 34 citations

Isolation and biochemical characterization of two isoforms of a boar sperm zona pellucida-binding protein

1992 • 33 citations

Human pre‐α‐trypsin inhibitor‐precursor heavy chain cDNA and deduced amino‐acid sequence

1993 • 33 citations

Plasminogen and Plasminogen Activator Assembly on the Human Endothelial Cell

1993 • 31 citations

Molecular mechanisms of protease-mediated tumor invasiveness

1993 • 27 citations

Effects of serine protease inhibitors on accumulation of polymorphonuclear leukocytes in the lung induced by acute pancreatitis in rats

1995 • 26 citations

Ectodermal stimulation of the production of hyaluronan‐dependent pericellular matrix by embryonic limb mesodermal cells

1995 • 24 citations

Identification of a novel serum and growth factor-inducible gene in vascular smooth muscle cells

1993 • 22 citations

Effect of protease inhibitor on ischemia/reperfusion injury of the rat liver

1994 • 21 citations

Crystallization and preliminary X‐ray diffraction analysis of boar seminal plasma spermadhesin PSP‐I/PSP‐II, a heterodimer of two CUB domains

1996 • 21 citations

Animal Models of Chronic Inflammatory Arthritis

1990 • 20 citations

Activation of the TSG-6 Gene by NF-IL6 Requires Two Adjacent NF-IL6 Binding Sites

1995 • 18 citations

The source of the inter‐alpha trypsin inhibitor in pathologic hyaluronateprotein

1971 • 14 citations

A chondroitin-sulfate chain is located on serine-10 of the urinary trypsin inhibitor

1991 • 12 citations

Expression and Characterization of a Single Recombinant Proteoglycan Tandem Repeat Domain of Link Protein That Binds Zinc and Hyaluronate

1995 • 10 citations

Further characterization of the binding of plasminogen to heparin: evidence for the involvement of lysine residues

1989 • 9 citations

TSG-6: A Novel Secretory Protein Inducible by Tumor Necrosis Factor or Interleukin-1 in Fibroblasts and Mononuclear Cells

2015 • 4 citations

Growth Factors in the Pathogenesis of Rheumatoid Arthritis

1995 • 1 citations