Identification of hyaluronic acid binding sites in the extracellular domain of CD44

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

CD44 is the principal cell surface receptor for hyaluronate

1990 • 2,433 citations

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

1991 • 1,685 citations

Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes

1991 • 1,088 citations

Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.

1992 • 1,040 citations

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

1987 • 802 citations

A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family

1989 • 680 citations

Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition.

1990 • 639 citations

The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells.

1991 • 587 citations

Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures.

1990 • 574 citations

A human lymphocyte homing receptor, the Hermes antigen, is related to cartilage proteoglycan core and link proteins

1989 • 568 citations

CD44 — A molecule involved in leukocyte adherence and T-cell activation

1989 • 559 citations

Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells.

1987 • 554 citations

Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin.

1992 • 542 citations

A lymphoid cell surface glycoprotein involved in endothelial cell recognition and lymphocyte homing in man

1986 • 435 citations

Characterization of the class III collagen receptor, a phosphorylated, transmembrane glycoprotein expressed in nucleated human cells.

1988 • 382 citations

Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons.

1991 • 377 citations

The hyaluronate receptor is a member of the CD44 (H-CAM) family of cell surface glycoproteins [published erratum appears in J Cell Biol 1991 Feb;112(3):following 513]

1990 • 368 citations

Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA clones.

1987 • 367 citations

Dual role of the CD44 molecule in T cell adhesion and activation.

1989 • 335 citations

CD44H regulates tumor cell migration on hyaluronate-coated substrate.

1992 • 334 citations

CD44 contributes to T cell activation.

1989 • 324 citations

Hyaluronate binding properties of versican.

1992 • 319 citations

Distinct effects of two CD44 isoforms on tumor growth in vivo.

1991 • 315 citations

LFA-3, CD44, and CD45: Physiologic Triggers of Human Monocyte TNF and IL-1 Release

1990 • 300 citations

A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.

1992 • 295 citations

Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody.

1992 • 261 citations

Multiple variants of the human lymphocyte homing receptor CD44 generated by insertions at a single site in the extracellular domain.

1992 • 236 citations

Antibodies against the CD44 p80, lymphocyte homing receptor molecule augment human peripheral blood T cell activation.

1990 • 230 citations

Cartilage proteoglycans. Structure and heterogeneity of the protein core and the effects of specific protein modifications on the binding to hyaluronate

1976 • 209 citations

Monoclonal antibody to a human brain‐granulocyte‐T lymphocyte antigen probably homologous to the W 3/13 antigen of the rat

1980 • 184 citations

Expression of CD44 is repressed in neuroblastoma cells.

1991 • 165 citations

Variations in the cytoskeletal interaction and posttranslational modification of the CD44 homing receptor in macrophages.

1991 • 146 citations

Effects of detergent solubilization on the hyaluronate-binding protein from membranes of simian virus 40-transformed 3T3 cells.

1983 • 141 citations

The tandemly repeated sequences of cartilage link protein contain the sites for interaction with hyaluronic acid.

1987 • 136 citations

Molecular cloning and expression of Pgp-1. The mouse homolog of the human H-CAM (Hermes) lymphocyte homing receptor.

1989 • 133 citations

Isolation and DNA sequence of a cDNA clone encoding a lymphocyte adhesion receptor for high endothelium.

1989 • 132 citations

Molecular isoforms of murine CD44 and evidence that the membrane proximal domain is not critical for hyaluronate recognition.

1992 • 129 citations

Structural homology between lymphocyte receptors for high endothelium and class III extracellular matrix receptor.

1989 • 129 citations

Structural heterogeneity of human Pgp-1 and its relationship with p85

1988 • 97 citations

Isolation of mouse CD44 cDNA: structural features are distinct from the primate cDNA.

1989 • 94 citations

Granule membrane protein 140 (GMP140) binds to carcinomas and carcinoma-derived cell lines.

1992 • 93 citations

Link protein cDNA sequence reveals a tandemly repeated protein structure.

1986 • 84 citations

Complete amino acid sequence of chicken cartilage link protein deduced from cDNA clones.

1986 • 84 citations

Murine cell surface glycoproteins. Characterization of a major component of 80,000 daltons as a polymorphic differentiation antigen of mesenchymal cells.

1981 • 77 citations

Genetic characterization of a polymorphic murine cell-surface glycoprotein

1982 • 75 citations

Human erythrocyte antigens: II. The In(Lu) gene regulates expression of an antigen on an 80-kilodalton protein of human erythrocytes

1984 • 64 citations

Somatic cell mutants distinguish CD44 expression and hyaluronic acid binding

1991 • 62 citations

Confirmation by peptide sequence and co-expression on various cell types of the identity of CD44 and P85 glycoprotein

1990 • 41 citations

Expression of CD44 Is Repressed in Neuroblastoma Cells

1991 • 39 citations

Sequence of the bovine CD44 cDNA: Comparison with human and mouse sequences

1991 • 37 citations

Specific chemical modifications of link protein and their effect on binding to hyaluronate and cartilage proteoglycan

1986 • 26 citations