MANIPULATION OF CYTOKINE NETWORKS IN TRANSPLANTATION

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

Cytokine signal transduction

1994 • 1,358 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

"Infectious" Transplantation Tolerance

1993 • 890 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

B-Cell Stimulatory Factor-1/Interleukin 4

1987 • 602 citations

T Helper Cell Subsets in Insulin-Dependent Diabetes

1995 • 600 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

1993 • 593 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.

1991 • 528 citations

Transforming growth factor beta: the good, the bad, and the ugly.

1994 • 491 citations

Th1 and Th2 subsets: paradigms lost?

1995 • 482 citations

IL-15: A Pleiotropic Cytokine with Diverse Receptor/Signaling Pathways Whose Expression Is Controlled at Multiple Levels

1996 • 459 citations

Oral tolerance.

1994 • 456 citations

Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T cells. The contribution of vascular cell adhesion molecule-1-dependent and -independent binding mechanisms.

1991 • 398 citations

IL-10: a novel cytotoxic T cell differentiation factor.

1991 • 391 citations

Dendritic cells and macrophages are required for Th1 development of CD4⁺ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-_γ production is IFN-_γ-dependent

1993 • 346 citations

HEART ALLOGRAFTS IN MURINE SYSTEMS

1992 • 299 citations

Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway.

1991 • 298 citations

IL-4 acts synergistically with IL-1 beta to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1.

1990 • 286 citations

Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction.

1991 • 267 citations

RANTES chemokine expression in cell-mediated transplant rejection of the kidney

1994 • 267 citations

Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production.

1993 • 251 citations

IL-10 stimulates monocyte Fc gamma R surface expression and cytotoxic activity. Distinct regulation of antibody-dependent cellular cytotoxicity by IFN-gamma, IL-4, and IL-10.

1992 • 220 citations

Multiple levels of peripheral tolerance

1993 • 216 citations

Interleukin 7 is a T-cell growth factor.

1989 • 206 citations

IL-2 knockout recipient mice reject islet cell allografts.

1995 • 204 citations

The IL-2/IL-2 receptor system: a target for rational immune intervention

1993 • 194 citations

Regulation of cytolytic T-lymphocyte generation by B-cell stimulatory factor

1987 • 193 citations

T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction.

1995 • 171 citations

Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation.

1995 • 171 citations

IL-4 inhibits IL-2-mediated induction of human lymphokine-activated killer cells, but not the generation of antigen-specific cytotoxic T lymphocytes in mixed leukocyte cultures.

1988 • 167 citations

Heightened intragraft CTL gene expression in acutely rejecting renal allografts.

1994 • 164 citations

Interleukin 7 enhances cytolytic T lymphocyte generation and induces lymphokine-activated killer cells from human peripheral blood.

1990 • 160 citations

Regulatory effects of transforming growth factor-beta on IL-2- and IL-4-dependent T cell-cycle progression.

1990 • 159 citations

T cell regulation in adult transplantation tolerance.

1996 • 144 citations

Unmodified pancreatic islet allograft rejection results in the preferential expression of certain T cell activation transcripts.

1993 • 136 citations

Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. Immunosuppression with TGF-beta 1 or vIL-10.

1995 • 132 citations

IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2.

1994 • 126 citations

ORAL, BUT NOT INTRAVENOUS, ALLOANTIGEN PREVENTS ACCELERATED ALLOGRAFT REJECTION BY SELECTIVE INTRAGRAFT TH2 CELL ACTIVATION

1993 • 124 citations

Pancreatic islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction.

1994 • 121 citations

PERIPHERAL TOLERANCE OF AN ALLOGRAFT IN ADULT RATS—CHARACTERIZATION BY LOW INTERLEUKIN-2 AND INTERFERON-γ mRNA LEVELS AND BY STRONG ACCUMULATION OF MAJOR HISTOCOMPATIBILITY COMPLEX TRANSCRIPTS IN THE GRAFT

1992 • 117 citations

MULTIPLE VECTORS EFFECTIVELY ACHIEVE GENE TRANSFER IN A MURINE CARDIAC TRANSPLANTATION MODEL IMMUNOSUPPRESSION WITH TGF-β OR vIL-10

1995 • 97 citations

Regulation of ICAM-1 expression and function in human dermal fibroblasts by IL-4.

1992 • 81 citations

CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines.

1993 • 76 citations

Prolonged islet allograft acceptance in the absence of interleukin 4 expression

1996 • 59 citations

Cytokine antagonists and their potential therapeutic use

1994 • 49 citations

The selective ablation of interleukin 2-producing cells isolated from transgenic mice.

1993 • 46 citations

Interleukin-2 Receptor-Directed Therapies: Antibody-or Cytokine-Based Targeting Molecules

1993 • 39 citations

LEW-TO-F344 CAROTID ARTERY ALLOGRAFTS

1995 • 37 citations

Interleukin-4 is chemotactic for mouse macrophages

1992 • 32 citations

An anergic, islet-infiltrating T-cell clone that suppresses murine diabetes secretes a factor that blocks interleukin 2/interleukin 4-dependent proliferation.

1992 • 19 citations

Acute retinal necrosis in a renal allograft recipient--an unusual manifestation of cytomegalovirus infection.

1993 • 7 citations

PRECURSOR FREQUENCY AND LYTIC SPECIFICITY OF INTERLEUKIN 2 AND INTERLEUKIN 4-RESPONSIVE MURINE LYMPHOCYTES

1990 • 5 citations