Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway.

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

1990 • 1,143 citations

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

1990 • 1,095 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen.

1984 • 742 citations

Interleukin 2 regulates its own receptors.

1985 • 414 citations

Induction of classical transplantation tolerance in the adult.

1989 • 325 citations

A Nondeletional Mechanism of Thymic Self Tolerance

1989 • 322 citations

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

1987 • 310 citations

Tolerance of class I histocompatibility antigens expressed extrathymically

1989 • 251 citations

Structure of the human interleukin 2 gene.

1983 • 197 citations

Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells.

1985 • 178 citations

A role for clonal inactivation in T cell tolerance to Mis-1a

1990 • 166 citations

Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression.

1986 • 166 citations

THE EFFECT OF DONOR STRAIN BLOOD PRETREATMENT ON RENAL ALLOGRAFT REJECTION IN RATS

1972 • 155 citations

Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.

1988 • 146 citations

PREVENTION OF REJECTION OF KIDNEY TRANSPLANTS BY MONOCLONAL ANTIBODY DIRECTED AGAINST INTERLEUKIN 2

1987 • 139 citations

Immunologic Tolerance: Collaboration Between Antigen and Lymphokines

1989 • 135 citations

Specific cytotoxic T cells are found in the nonrejected kidneys of blood-transfused rats.

1987 • 119 citations

Self-tolerance to transgenic γδ T cells by intrathymic inactivation

1990 • 87 citations

Organization and structure of the mouse interleukin-2 gene

1984 • 83 citations

Prolonged survival of actively enhanced rat renal allografts despite accelerated cellular infiltration and rapid induction of both class I and class II MHC antigens.

1987 • 82 citations

Acquired immunological tolerance of foreign cells is impaired by recombinant interleukin 2 or vitamin A acetate.

1985 • 72 citations

Sequence of rat interleukin 2 and anomalous binding of a mouse interleukin 2 cDNA probe to rat MHC class II-associated invariant chain mRNA

1989 • 71 citations

Stimulation of T Cells Through the CD3/T-Cell Receptor Complex: Role of Cytoplasmic Calcium, Protein Kinase C Translocation, and Phosphorylation of pp60^c-src in the Activation Pathway

1987 • 66 citations

Mechanism of action of interleukin-2 receptor (IL-2R) monoclonal antibody (MAb) therapy: target cell depletion or inhibition of function?

1989 • 41 citations

LACK OF CORRELATION BETWEEN THE INDUCTION OF DONOR CLASS I AND CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS AND GRAFT REJECTION

1988 • 25 citations

FAILURE TO ALTER NEONATAL TRANSPLANTATION TOLERANCE BY THE INJECTION OF INTERLEUKIN

1988 • 3 citations