Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast.

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1989 • 8,705 citations

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1988 • 4,543 citations

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1986 • 3,400 citations

Multifunctional yeast high-copy-number shuttle vectors

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Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.

1988 • 983 citations

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The structure of an antigenic determinant in a protein

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Replacement of chromosome segments with altered DNA sequences constructed in vitro.

1979 • 779 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

Protein degradation in the endoplasmic reticulum

1990 • 659 citations

Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP

1993 • 650 citations

Guide to Yeast Genetics and Molecular Biology

1991 • 607 citations

Glycoprotein biosynthesis in yeast

1993 • 514 citations

Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum

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1984 • 490 citations

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1988 • 488 citations

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1992 • 472 citations

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1993 • 447 citations

Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum

1994 • 430 citations

The yeast Ca(2+)-ATPase homologue, PMR1, is required for normal Golgi function and localizes in a novel Golgi-like distribution.

1992 • 429 citations

Molecular chaperones in protein folding: the art of avoiding sticky situations

1994 • 402 citations

A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins.

1992 • 375 citations

Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells.

1992 • 348 citations

Purification of a RAS-Responsive Adenylyl Cyclase Complex from Saccharomyces cerevisiae by Use of an Epitope Addition Method

1988 • 328 citations

The Promoter Region of the Yeast KAR2 (BiP) Gene Contains a Regulatory Domain that Responds to the Presence of Unfolded Proteins in the Endoplasmic Reticulum

1993 • 328 citations

Folding of VSV G Protein: Sequential Interaction with BiP and Calnexin

1994 • 316 citations

Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protease

1987 • 312 citations

Sorting of soluble ER proteins in yeast.

1988 • 270 citations

[40] H+-ATPase from plasma membranes of Saccharomyces cerevisiae and Avena sativa roots: Purification and reconstitution

1988 • 265 citations

Physical maps of the six smallest chromosomes of Saccharomyces cerevisiae at a resolution of 2.6 kilobase pairs.

1993 • 251 citations

Functional compartments of the yeast Golgi apparatus are defined by the sec7 mutation.

1989 • 249 citations

The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum.

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A Peptide Sequence Confers Retention and Rapid Degradation in the Endoplasmic Reticulum

1990 • 219 citations

Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast

1993 • 205 citations

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1990 • 196 citations

Degradation of proteins within the endoplasmic reticulum

1991 • 191 citations

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1992 • 187 citations

Structure of the yeast endoplasmic reticulum: Localization of ER proteins using immunofluorescence and immunoelectron microscopy

1991 • 184 citations

Regulated import and degradation of a cytosolic protein in the yeast vacuole

1991 • 174 citations

Yeast G1 cyclins CLN1 and CLN2 and a GAP-like protein have a role in bud formation.

1993 • 172 citations

Two crystal structures for cathepsin D: the lysosomal targeting signal and active site.

1993 • 161 citations

ERD1, a yeast gene required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus.

1990 • 160 citations

The modification and assembly of proteins in the endoplasmic reticulum

1993 • 156 citations

Endoplasmic reticulum: a dynamic patchwork of specialized subregions.

1992 • 154 citations

The yeast EUG1 gene encodes an endoplasmic reticulum protein that is functionally related to protein disulfide isomerase.

1992 • 150 citations

Molecular chaperones involved in protein degradation in the endoplasmic reticulum: quantitative interaction of the heat shock cognate protein BiP with partially folded immunoglobulin light chains that are degraded in the endoplasmic reticulum.

1995 • 145 citations

Quality control of ER synthesized proteins: an exposed thiol group as a three-way switch mediating assembly, retention and degradation.

1993 • 141 citations

Vma21p is a yeast membrane protein retained in the endoplasmic reticulum by a di-lysine motif and is required for the assembly of the vacuolar H(+)-ATPase complex.

1994 • 116 citations

Depletion of cellular calcium accelerates protein degradation in the endoplasmic reticulum

1991 • 105 citations

The KKXX signal mediates retrieval of membrane proteins from the Golgi to the ER in yeast.

1994 • 89 citations

Mapping and molecular modeling of a recognition domain for lysosomal enzyme targeting.

1991 • 79 citations

Analysis in vivo of GRP78-BiP/substrate interactions and their role in induction of the GRP78-BiP gene.

1992 • 70 citations

Regulation of selective protein degradation in the endoplasmic reticulum by redox potential.

1993 • 58 citations

In vivo iodination of a misfolded proinsulin reveals co-localized signals for Bip binding and for degradation in the ER.

1995 • 53 citations

3-Hydroxy-3-methylglutaryl-coenzyme A reductase and T cell receptor alpha subunit are differentially degraded in the endoplasmic reticulum.

1992 • 52 citations

The Endoplasmic Reticulum as a Site of Protein Degradation

1993 • 39 citations

The Yeast EUG1 Gene Encodes an Endoplasmic Reticulum Protein That Is Functionally Related to Protein Disulfide Isomerase

1992 • 35 citations

Vesicle-Mediated Protein Sorting

1992 • 32 citations

<scp>II</scp>. Yeast sequencing reports. Nucleotide sequence analysis of an 11·7 kb fragment of yeast chromosome II including BEM1, a new gene of the WD‐40 repeat family and a new member of the KRE2/MNT1 family

1994 • 19 citations

Regulated import and degradation of a cytosolic protein in the yeast vacuole

1991 • 5 citations

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