Protein-disulfide Isomerase-mediated Reduction of the A Subunit of Cholera Toxin in a Human Intestinal Cell Line

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

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1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Brefeldin A: insights into the control of membrane traffic and organelle structure.

1992 • 1,848 citations

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1982 • 1,765 citations

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1984 • 595 citations

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1994 • 506 citations

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1989 • 466 citations

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1992 • 271 citations

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1987 • 254 citations

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1989 • 250 citations

Inhibition of a reductive function of the plasma membrane by bacitracin and antibodies against protein disulfide-isomerase.

1993 • 235 citations

Cleavage of disulfide bonds in endocytosed macromolecules. A processing not associated with lysosomes or endosomes.

1990 • 225 citations

Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography

1992 • 197 citations

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1996 • 166 citations

Coordinated assembly of multisubunit proteins: oligomerization of bacterial enterotoxins in vivo and in vitro.

1988 • 141 citations

The Preparation of Subcellular Organelles from Mouse Liver in Self-Generated Gradients of Iodixanol

1994 • 138 citations

Protein disulfide-isomerase in rat exocrine pancreatic cells is exported from the endoplasmic reticulum despite possessing the retention signal.

1990 • 131 citations

Brefeldin A blocks the response of cultured cells to cholera toxin. Implications for intracellular trafficking in toxin action

1993 • 126 citations

Bacitracin: An inhibitor of the insulin degrading activity of glutathione-insulin transhydrogenase

1981 • 106 citations

Transcytosis in the continuous endothelium of the myocardial microvasculature is inhibited by N-ethylmaleimide.

1994 • 102 citations

Photolabelling of cholera toxin subunits during membrane penetration

1981 • 99 citations

Entry of cholera toxin into polarized human intestinal epithelial cells. Identification of an early brefeldin A sensitive event required for A1-peptide generation.

1993 • 98 citations

Lipid insertion of cholera toxin after binding to GM1-containing liposomes.

1981 • 87 citations

Cell surface sulfhydryls are required for the cytotoxicity of diphtheria toxin but not of ricin in Chinese hamster ovary cells.

1991 • 86 citations

Characterization of the receptor for cholera toxin and Escherichia coli heat-labile toxin in rabbit intestinal brush borders

1986 • 82 citations

Mechanism of action of cholera toxin: Studies on the lag period

1980 • 82 citations

Purification and Characterization of Yeast Protein Disulfide Isomerase

1990 • 79 citations

Enzymatic Catalysis of Disulfide Formation

1994 • 77 citations

Mechanism of action of cholera toxin on intact cells. Generation of A1 peptide and activation of adenylate cyclase.

1982 • 72 citations

Protein disulphide-isomerase from human placenta and rat liver. Purification and immunological characterization with monoclonal antibodies

1987 • 67 citations

Involvement of the Golgi region in the intracellular trafficking of cholera toxin

1993 • 61 citations

Fusion proteins containing the A2 domain of cholera toxin assemble with B polypeptides of cholera toxin to form immunoreactive and functional holotoxin-like chimeras

1992 • 59 citations

The N-terminal region of the 37-kDa translocated fragment of Pseudomonas exotoxin A aborts translocation by promoting its own export after microsomal membrane insertion.

1993 • 51 citations

Desensitization of catecholamine-stimulated adenylate cyclase and down-regulation of beta-adrenergic receptors in rat glioma C6 cells. Role of cyclic AMP and protein synthesis.

1984 • 50 citations

Intermolecular interactions between the A and B subunits of heat-labile enterotoxin from Escherichia coli promote holotoxin assembly and stability in vivo.

1992 • 47 citations

Activation of choleragen by thiol: protein disulfide oxidoreductase.

1980 • 45 citations

Inhibition of heat-labile cholera and Escherichia coli enterotoxins by brefeldin A

1993 • 41 citations

A recombinant form of Pseudomonas exotoxin directed at the epidermal growth factor receptor that is cytotoxic without requiring proteolytic processing.

1992 • 38 citations

Insulin degradation XXIII. Distribution of glutathione-insulin transhydrogenase in isolated rat hepatocytes as studied by immuno-ferritin and electron microscopy

1978 • 37 citations

Brefeldin A inhibits protein synthesis in cultured cells

1992 • 36 citations

pH-induced transitions in cholera toxin conformation: a fluorescence study

1987 • 28 citations

[34] [32P]ADP-ribosylation of proteins catalyzed by cholera toxin and related heat-labile enterotoxins

1988 • 24 citations

Orientation of cholera toxin bound to target cells

1993 • 24 citations

Localization of glutathione-insulin transhydrogenase (protein-disulfide interchange enzyme) in pancreas using immunocytochemistry, immunodiffusion, and enzymatic activity assay techniques.

1985 • 9 citations