IL-23-Mediated Epidermal Hyperplasia Is Dependent on IL-6

Development, cytokine profile and function of human interleukin 17–producing helper T cells

2007 • 1,962 citations

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

2007 • 1,808 citations

Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

2006 • 1,806 citations

Pathogenesis and therapy of psoriasis

2007 • 1,652 citations

TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

2007 • 1,448 citations

IL-22 Increases the Innate Immunity of Tissues

2004 • 1,330 citations

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

2009 • 1,296 citations

A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R

2002 • 1,238 citations

The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis

2009 • 1,027 citations

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

2008 • 1,020 citations

IL‐22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

2006 • 898 citations

Increased Expression of Interleukin 23 p19 and p40 in Lesional Skin of Patients with Psoriasis Vulgaris

2004 • 873 citations

Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes.

1989 • 844 citations

IL-22 Inhibits Epidermal Differentiation and Induces Proinflammatory Gene Expression and Migration of Human Keratinocytes

2005 • 817 citations

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

2009 • 799 citations

Guidelines of care for the management of psoriasis and psoriatic arthritis

2008 • 761 citations

Discovery and Biology of IL-23 and IL-27: Related but Functionally Distinct Regulators of Inflammation

2006 • 752 citations

Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways

2008 • 750 citations

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis

2006 • 662 citations

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

2006 • 629 citations

Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis

2009 • 597 citations

Cutting Edge: Immune Cells as Sources and Targets of the IL-10 Family Members?

2002 • 580 citations

Guidelines of care for the management of psoriasis and psoriatic arthritis

2009 • 523 citations

IL-10–producing and naturally occurring CD4+ Tregs: limiting collateral damage

2004 • 512 citations

Getting under the skin: the immunogenetics of psoriasis

2005 • 465 citations

Immunopathogenesis of psoriasis

2007 • 377 citations

Biology of interleukin-22

2010 • 375 citations

IL-6 Signaling in Psoriasis Prevents Immune Suppression by Regulatory T Cells

2009 • 307 citations

Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1α, and TNF-α Recapitulates Some Features of Psoriasis

2010 • 305 citations

Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array

2003 • 298 citations

Type I Interferon: Potential Therapeutic Target for Psoriasis?

2008 • 290 citations

Assessment of the Psoriatic Transcriptome in a Large Sample: Additional Regulated Genes and Comparisons with In Vitro Models

2010 • 226 citations

CCR6 is required for IL-23–induced psoriasis-like inflammation in mice

2009 • 220 citations

MicroRNAs and potential target interactions in psoriasis

2010 • 209 citations

The cytokine and chemokine network in psoriasis

2007 • 176 citations

Regulatory Role of Endogenous Interleukin-10 in Cutaneous Inflammatory Response of Murine Wound Healing

1999 • 169 citations

Increased IL-6 Production by Monocytes and Keratinocytes in Patients with Psoriasis

1991 • 162 citations

IL-23 Production by Cosecretion of Endogenous p19 and Transgenic p40 in Keratin 14/p40 Transgenic Mice: Evidence for Enhanced Cutaneous Immunity

2003 • 130 citations

Interplay between keratinocytes and immune cells—Recent insights into psoriasis pathogenesis

2008 • 107 citations

Studies of the Effect of Cyclosporine in Psoriasis In Vivo: Combined Effects on Activated T Lymphocytes and Epidermal Regenerative Maturation

1992 • 105 citations

Murine NKT cells produce Th17 cytokine interleukin-22

2008 • 103 citations

Review Paper: Preclinical Models of Psoriasis

2008 • 89 citations

Changes in Keratin 6 and Keratin 10 (Co-)Expression in Lesional and Symptomless Skin of Spreading Psoriasis

2000 • 68 citations

Abnormal Distribution of Epidermal Protein Antigens in Psoriatic Epidermis

1991 • 62 citations

Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis

2009 • 60 citations

Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart

2004 • 55 citations

Keratinocytes as targets for interleukin-10-related cytokines: a putative role in the pathogenesis of psoriasis.

2005 • 53 citations

Co-Localization of Susceptibility Loci for Psoriasis (PSORS4) and Atopic Dermatitis (ATOD2) on Human Chromosome 1q21

2006 • 37 citations