A Necessary Good: Nuclear Hormone Receptors and Their Chromatin Templates

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

The language of covalent histone modifications

2000 • 8,260 citations

ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

1964 • 2,410 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

CBP/p300 in cell growth, transformation, and development

2000 • 1,712 citations

Acetylation of Histones and Transcription-Related Factors

2000 • 1,702 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase

1997 • 1,251 citations

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

1997 • 1,218 citations

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

1993 • 1,116 citations

Crystal structure of a yeast TBP/TATA-box complex

1993 • 1,082 citations

The role of general initiation factors in transcription by RNA polymerase II

1996 • 1,001 citations

NURD, a Novel Complex with Both ATP-Dependent Chromatin-Remodeling and Histone Deacetylase Activities

1998 • 946 citations

Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

1997 • 945 citations

Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.

1996 • 922 citations

A direct link between core histone acetylation and transcriptionally active chromatin.

1988 • 905 citations

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

1997 • 856 citations

Chromatin as an essential part of the transcriptional mechanim

1992 • 853 citations

Stimulation of GAL4 Derivative Binding to Nucleosomal DNA by the Yeast SWI/SNF Complex

1994 • 853 citations

The Glucocorticoid Receptor: Rapid Exchange with Regulatory Sites in Living Cells

2000 • 791 citations

Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex

1994 • 766 citations

Nuclear Membrane Dynamics and Reassembly in Living Cells: Targeting of an Inner Nuclear Membrane Protein in Interphase and Mitosis

1997 • 753 citations

Components and Dynamics of DNA Replication Complexes in S. cerevisiae: Redistribution of MCM Proteins and Cdc45p during S Phase

1997 • 743 citations

ATP-Dependent Chromatin-Remodeling Complexes

2000 • 734 citations

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

1999 • 733 citations

The Mechanism of Action of Thyroid Hormones

2000 • 719 citations

In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition.

1996 • 709 citations

ATP-dependent remodeling and acetylation as regulators of chromatin fluidity

1999 • 705 citations

Diversity and specialization of mammalian SWI/SNF complexes.

1996 • 703 citations

Ordered Recruitment of Transcription and Chromatin Remodeling Factors to a Cell Cycle– and Developmentally Regulated Promoter

1999 • 703 citations

The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression

1993 • 692 citations

Partial Hormone Resistance in Mice with Disruption of the Steroid Receptor Coactivator-1 (SRC-1) Gene

1998 • 685 citations

Lateral diffusion of rhodopsin in the photoreceptor membrane

1974 • 658 citations

The role of general initiation factors in transcription by RNA polymerase II

1996 • 653 citations

The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors

1999 • 637 citations

Regulation of Hormone-Induced Histone Hyperacetylation and Gene Activation via Acetylation of an Acetylase

1999 • 630 citations

Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3

2000 • 625 citations

Mapping proteinDNA interactions in vivo with formaldehyde: Evidence that histone H4 is retained on a highly transcribed gene

1988 • 619 citations

Architecture of RNA Polymerase II and Implications for the Transcription Mechanism

2000 • 615 citations

Histone acetylases and deacetylases in cell proliferation

1999 • 598 citations

Facilitated binding of TATA-binding protein to nucleosomal DNA

1994 • 593 citations

Structural determinants of nuclear receptor assembly on DNA direct repeats

1995 • 561 citations

Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain.

1994 • 539 citations

Chromatin disruption and modification

1999 • 537 citations

Evidence that SNF2/SWI2 and SNF5 activate transcription in yeast by altering chromatin structure.

1992 • 535 citations

Biology as Ideology: The Doctrine of DNA

1991 • 525 citations

Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex

1998 • 507 citations

Loading of an Mcm Protein onto DNA Replication Origins Is Regulated by Cdc6p and CDKs

1997 • 503 citations

Diffusional Mobility of Golgi Proteins in Membranes of Living Cells

1996 • 499 citations

A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness

2000 • 482 citations

Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro.

1996 • 469 citations

Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme

1999 • 457 citations

A Novel Histone Acetyltransferase Is an Integral Subunit of Elongating RNA Polymerase II Holoenzyme

1999 • 453 citations

Reversible and persistent changes in chromatin structure accompany activation of a glucocorticoid-dependent enhancer element

1984 • 449 citations

Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo

1998 • 444 citations

Induktion von puff-veränderungen in den speicheldrüsenchromosomen von Chironomus t̆entans durch Ecdyson

1960 • 434 citations

Composite co-activator ARC mediates chromatin-directed transcriptional activation

1999 • 429 citations

Histone deacetylases: silencers for hire

2000 • 429 citations

A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase

1998 • 426 citations

Perturbation of Nuclear Architecture by Long-Distance Chromosome Interactions

1996 • 425 citations

Identity between TRAP and SMCC Complexes Indicates Novel Pathways for the Function of Nuclear Receptors and Diverse Mammalian Activators

1999 • 421 citations

Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3

1998 • 421 citations

Overlapping but Distinct Patterns of Histone Acetylation by the Human Coactivators p300 and PCAF within Nucleosomal Substrates

1999 • 411 citations

Transcription Factor Loading on the MMTV Promoter: A Bimodal Mechanism for Promoter Activation

1992 • 411 citations

Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression

2000 • 409 citations

Nuclear Hormone Receptor Coregulators In Action: Diversity For Shared Tasks

2000 • 377 citations

Binding of the winged-helix transcription factor HNF3 to a linker histone site on the nucleosome

1998 • 373 citations

The histone deacetylase-3 complex contains nuclear receptor corepressors

2000 • 367 citations

Thyroid hormone receptor β is essential for development of auditory function

1996 • 363 citations

Biomedical Discovery with DNA Arrays

2000 • 362 citations

Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors.

1995 • 361 citations

Nucleosome mobilization catalysed by the yeast SWI/SNF complex

1999 • 354 citations

The structure of DNA in a nucleosome.

1990 • 353 citations

Review: Chromatin Structural Features and Targets That Regulate Transcription

2000 • 348 citations

The Swi/Snf family

2000 • 343 citations

p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation

1998 • 337 citations

An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array

1993 • 336 citations

Golgi Membranes Are Absorbed into and Reemerge from the ER during Mitosis

1999 • 329 citations

The vitamin D hormone and its nuclear receptor: molecular actions and disease states.

1997 • 325 citations

Targeted Recruitment of the Sin3-Rpd3 Histone Deacetylase Complex Generates a Highly Localized Domain of Repressed Chromatin In Vivo

1998 • 319 citations

Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase

1998 • 318 citations

Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway

2000 • 317 citations

Acetylated histone H4 on the male X chromosome is associated with dosage compensation in Drosophila.

1994 • 308 citations

Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes

1999 • 308 citations

Characterization of a human RPD3 ortholog, HDAC3

1998 • 292 citations

Transcriptional Repression by Nuclear Hormone Receptors

2000 • 291 citations

Cell cycle-regulated histone acetylation required for expression of the yeast HO gene

1999 • 275 citations

In vivo footprinting of rat TAT gene: Dynamic interplay between the glucocorticoid receptor and a liver-specific factor

1991 • 270 citations

Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression.

1993 • 262 citations

Transcriptional Regulation of Mammalian Genes in Vivo

1997 • 244 citations

Enhancement of TBP binding by activators and general transcription factors

1999 • 237 citations

Histone acetylation: influence on transcription, nucleosome mobility and positioning, and linker histone-dependent transcriptional repression

1997 • 236 citations

An Early Developmental Transcription Factor Complex that Is More Stable on Nucleosome Core Particles Than on Free DNA

1999 • 233 citations

A role for nucleosome assembly in both silencing and activation of the Xenopus TR beta A gene by the thyroid hormone receptor.

1995 • 225 citations

The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast

1996 • 223 citations

The Something About Silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF_II30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)–FACT complex

2000 • 221 citations

A nucleosome-dependent static loop potentiates estrogen-regulated transcription from the Xenopus vitellogenin B1 promoter in vitro.

1993 • 219 citations

Mobility of positioned nucleosomes on 5 S rDNA

1991 • 211 citations

p300-Mediated acetylation facilitates the transfer of histone H2A–H2B dimers from nucleosomes to a histone chaperone

2000 • 209 citations

Ikaros Interactions with CtBP Reveal a Repression Mechanism That Is Independent of Histone Deacetylase Activity

2000 • 201 citations

Proteasome-mediated degradation of transcriptional activators correlates with activation domain potency in vivo

1999 • 190 citations

Nucleosome positioning and modification: chromatin structures that potentiate transcription

1994 • 182 citations

Perturbation of nucleosome core structure by the SWI/SNF complex persists after its detachment, enhancing subsequent transcription factor binding

1998 • 180 citations

De novo nucleosome assembly: new pieces in an old puzzle

2000 • 176 citations

Budding yeast centromere composition and assembly as revealed by in vivo cross-linking

1997 • 173 citations

Nucleosome positioning on the MMTV LTR results from the frequency-biased occupancy of multiple frames.

1995 • 171 citations

Yeast alpha 2 repressor positions nucleosomes in TRP1/ARS1 chromatin.

1990 • 161 citations

Stable nucleosome positioning and complete repression by the yeast alpha 2 repressor are disrupted by amino-terminal mutations in histone H4.

1992 • 160 citations

Architectural variations of inducible eukaryotic promoters: Preset and remodeling chromatin structures

1994 • 160 citations

Steroid Regulation of Postembryonic Development and Reproduction in Drosophila

2000 • 155 citations

Cis and trans requirements for stable episomal maintenance of the BPV-1 replicator.

1996 • 153 citations

Determinants of chromatin disruption and transcriptional regulation instigated by the thyroid hormone receptor: hormone-regulated chromatin disruption is not sufficient for transcriptional activation

1997 • 149 citations

Overlapping roles for the histone acetyltransferase activities of SAGA and Elongator in vivo

2000 • 149 citations

Hormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors

2000 • 145 citations

A role for helix 3of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone

1998 • 142 citations

Retinoic acid and retinoic acid receptors in development

1995 • 138 citations

Glucocorticoid receptor-dependent disruption of a specific nucleosome on the mouse mammary tumor virus promoter is prevented by sodium butyrate.

1990 • 135 citations

Chromatin remodelling at the PHO8 promoter requires SWI–SNF and SAGA at a step subsequent to activator binding

1999 • 133 citations

Translational positioning of a nucleosomal glucocorticoid response element modulates glucocorticoid receptor affinity.

1993 • 133 citations

Nucleosome-mediated disruption of transcription factor-chromatin initiation complexes at the mouse mammary tumor virus long terminal repeat in vivo.

1994 • 128 citations

Recruitment of the SWI-SNF Chromatin Remodeling Complex as a Mechanism of Gene Activation by the Glucocorticoid Receptor τ1 Activation Domain

2000 • 127 citations

p300 Requires Its Histone Acetyltransferase Activity and SRC-1 Interaction Domain To Facilitate Thyroid Hormone Receptor Activation in Chromatin

2000 • 126 citations

Accessibility of a Glucocorticoid Response Element in a Nucleosome Depends on Its Rotational Positioning

1995 • 126 citations

Two-Step Synergism between the Progesterone Receptor and the DNA-Binding Domain of Nuclear Factor 1 on MMTV Minichromosomes

1999 • 125 citations

Nucleosome positioning by the winged helix transcription factor HNF3

1998 • 125 citations

Hormone-induced Translocation of Thyroid Hormone Receptors in Living Cells Visualized Using a Receptor Green Fluorescent Protein Chimera

1998 • 124 citations

Unliganded Thyroid Hormone Receptor α Can Target TATA-Binding Protein for Transcriptional Repression

1996 • 123 citations

Distribution of acetylated histones resulting from Gal4-VP16 recruitment of SAGA and NuA4 complexes

2000 • 122 citations

Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors

1995 • 121 citations

A natural transactivation mutation in the thyroid hormone β receptor: Impaired interaction with putative transcriptional mediators

1997 • 117 citations

Stable co-occupancy of transcription factors and histones at the HIV-1 enhancer

1997 • 117 citations

Nucleosome Mobility and the Maintenance of Nucleosome Positioning

1997 • 105 citations

X-Linked Late-Onset Sensorineural Deafness Caused by a Deletion Involving OA1 and a Novel Gene Containing WD-40 Repeats

1999 • 104 citations

The interaction of transcription factors with nucleosomal DNA

1992 • 99 citations

Chromatin assembly: biochemical identities and genetic redundancy

1999 • 99 citations

Moderate increase in histone acetylation activates the mouse mammary tumor virus promoter and remodels its nucleosome structure.

1996 • 97 citations

The thyroid hormone receptor functions as a ligand-operated developmental switch between proliferation and differentiation of erythroid progenitors

1998 • 94 citations

Genomic organization and alternative promoter usage of the two thyroid hormone receptor beta genes in Xenopus laevis.

1992 • 92 citations

Structure and Dynamic Properties of a Glucocorticoid Receptor-Induced Chromatin Transition

2000 • 90 citations

Structural and functional features of a specific nucleosome containing a recognition element for the thyroid hormone receptor

1997 • 87 citations

Differential steroid hormone induction of transcription from the mouse mammary tumor virus promoter.

1994 • 87 citations

Amphibian metamorphosis as a model for studying the developmental actions of thyroid hormone

1999 • 81 citations

Targeting of N-CoR and histone deacetylase 3 by the oncoprotein v-ErbA yields a chromatin infrastructure-dependent transcriptional repression pathway

2000 • 80 citations

Resistance to Thyroid Hormone

1997 • 79 citations

Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin

1999 • 79 citations

Interplay of yeast global transcriptional regulators Ssn6p-Tup1p and Swi-Snf and their effect on chromatin structure

1997 • 78 citations

Hormone activation induces nucleosome positioning in vivo

2000 • 70 citations

Mutations in both the structured domain and N-terminus of histone H2B bypass the requirement for Swi-Snf in yeast

1999 • 70 citations

Evidence that Snf-Swi controls chromatin structure over both the TATA and UAS regions of the SUC2 promoter in Saccharomyces cerevisiae

1997 • 64 citations

Retinoid receptors in transcriptional regulation

1996 • 63 citations

Co-repressor complexes and remodelling chromatin for repression

2000 • 61 citations

Binding of TATA Binding Protein to a Naturally Positioned Nucleosome Is Facilitated by Histone Acetylation

2001 • 61 citations

The Position and Length of the Steroid-Dependent Hypersensitive Region in the Mouse Mammary Tumor Virus Long Terminal Repeat Are Invariant despite Multiple Nucleosome B Frames

1998 • 56 citations

Nucleosome Positioning and Transcription-associated Chromatin Alterations on the Human Estrogen-responsive pS2 Promoter

1997 • 54 citations

Transcriptional State of the Mouse Mammary Tumor Virus Promoter Can Affect Topological Domain Size in Vivo

1999 • 52 citations

Ligand-dependent activation of transcription in vitro by retinoic acid receptor α/retinoid X receptor α heterodimers that mimics transactivation by retinoids in vivo

1999 • 49 citations

Functional dissection of in vivo interchromosome association in Saccharomyces cerevisiae

2000 • 48 citations

Understanding nuclear receptor function: From DNA to chromatin to the interphase nucleus

2000 • 47 citations

Retinoid-Induced Chromatin Structure Alterations in the Retinoic Acid Receptor β2 Promoter

1997 • 46 citations

The Assembly of Regularly Spaced Nucleosomes in the Xenopus Oocyte S-150 Extract Is Accompanied by Deacetylation of Histone H4

1989 • 46 citations

Amphibian Metamorphosis: A Complex Program of Gene Expression Changes Controlled by the Thyroid Hormone

1995 • 42 citations

Organization of the Thyroid Hormone Receptor in Chromatin

1982 • 41 citations

Enhanced transcription factor access to arrays of histone H3/H4 tetramer⋅DNA complexes in vitro : Implications for replication and transcription

1998 • 31 citations

Leukemia: the sophisticated subversion of hematopoiesis by nuclear receptor oncoproteins

1999 • 17 citations

Retinoid Receptor-Induced Alteration of the Chromatin Assembled on a Ligand-Responsive Promoter inXenopusOocytes

1998 • 15 citations

GAGA Factor-dependent Transcription and Establishment of DNase Hypersensitivity Are Independent and Unrelated Events in Vivo

2000 • 12 citations