Hormone activation induces nucleosome positioning in vivo

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2001 • 133,517 citations

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

Genomic sequencing.

1984 • 8,343 citations

Coactivator and corepressor complexes in nuclear receptor function

1999 • 909 citations

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

1999 • 733 citations

Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA

1986 • 722 citations

ATP-dependent remodeling and acetylation as regulators of chromatin fluidity

1999 • 705 citations

Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region

1983 • 700 citations

A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor.

1993 • 598 citations

Sequence-specific positioning of nucleosomes over the steroid-inducible MMTV promoter.

1987 • 597 citations

Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex

1998 • 507 citations

Roles of SWI1, SWI2, and SWI3 Proteins for Transcriptional Enhancement by Steroid Receptors

1992 • 477 citations

Reversible and persistent changes in chromatin structure accompany activation of a glucocorticoid-dependent enhancer element

1984 • 449 citations

Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo

1987 • 448 citations

Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter

1990 • 440 citations

Transcription Factor Loading on the MMTV Promoter: A Bimodal Mechanism for Promoter Activation

1992 • 411 citations

Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast

1999 • 389 citations

Transcription and translation : a Practical Approach

1984 • 375 citations

Transcription factor access is mediated by accurately positioned nucleosomes on the mouse mammary tumor virus promoter.

1991 • 372 citations

Nucleosome Movement by CHRAC and ISWI without Disruption or trans-Displacement of the Histone Octamer

1999 • 357 citations

Nucleosome mobilization catalysed by the yeast SWI/SNF complex

1999 • 354 citations

ATP-Dependent Histone Octamer Sliding Mediated by the Chromatin Remodeling Complex NURF

1999 • 334 citations

Specific glucocorticoid receptor binding to DNA reconstituted in a nucleosome.

1988 • 316 citations

Hormone induces binding of receptors and transcription factors to a rearranged nucleosome on the MMTV promoter in vivo.

1995 • 313 citations

Sequence-specific interactions of nuclear factors with the insulin gene enhancer

1986 • 309 citations

Histone contributions to the structure of DNA in the nucleosome.

1991 • 256 citations

Nucleosome Positioning: Occurrence, Mechanisms, and Functional Consequences

1991 • 248 citations

Depletion of histone H4 and nucleosomes activates the PHO5 gene in Saccharomyces cerevisiae.

1988 • 226 citations

A role for nucleosome assembly in both silencing and activation of the Xenopus TR beta A gene by the thyroid hormone receptor.

1995 • 225 citations

The transcriptionally-active MMTV promoter is depleted of histone H1

1992 • 222 citations

A nucleosome-dependent static loop potentiates estrogen-regulated transcription from the Xenopus vitellogenin B1 promoter in vitro.

1993 • 219 citations

Metal binding ‘finger’ structures in the glucocorticoid receptor defined by site-directed mutagenesis.

1988 • 199 citations

Nucleosome positioning on the MMTV LTR results from the frequency-biased occupancy of multiple frames.

1995 • 171 citations

Replication-coupled chromatin assembly is required for the repression of basal transcription in vivo.

1993 • 163 citations

Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase

1998 • 161 citations

Glucocorticoid Receptor-Glucocorticoid Response Element Binding Stimulates Nucleosome Disruption by the SWI/SNF Complex

1997 • 159 citations

Distinct sequence elements involved in the glucocorticoid regulation of the mouse mammary tumor virus promoter identified by linker scanning mutagenesis

1986 • 158 citations

An indelible lineage marker for Xenopus using a mutated green fluorescent protein

1996 • 157 citations

Positioning and stability of nucleosomes on MMTV 3′LTR sequences

1998 • 133 citations

Nucleosome positioning by the winged helix transcription factor HNF3

1998 • 125 citations

Two-Step Synergism between the Progesterone Receptor and the DNA-Binding Domain of Nuclear Factor 1 on MMTV Minichromosomes

1999 • 125 citations

Two Regions of the Mouse Mammary Tumor Virus Long Terminal Repeat Regulate the Activity of Its Promoter in Mammary Cell Lines

1991 • 88 citations

Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin

1999 • 79 citations

Cooperation between structural elements in hormonoregulated transcription from the mouse mammary tumor virus promoter

1991 • 73 citations

[14] Analysis of hypersensitive sites in chromatin

1989 • 72 citations

The role of a positioned nucleosome at the Drosophila melanogaster hsp26 promoter.

1995 • 62 citations

The Position and Length of the Steroid-Dependent Hypersensitive Region in the Mouse Mammary Tumor Virus Long Terminal Repeat Are Invariant despite Multiple Nucleosome B Frames

1998 • 56 citations

The mouse mammary tumour virus promoter positioned on a tetramer of histones H3 and H4 binds nuclear factor 1 and OTF1

1998 • 56 citations

Nucleosome Positioning and Transcription-associated Chromatin Alterations on the Human Estrogen-responsive pS2 Promoter

1997 • 54 citations

Inhibition of Chromatin Assembly in Xenopus Oocytes Correlates with Derepression of the Mouse Mammary Tumor Virus Promoter

1991 • 42 citations

Expression of human estrogen receptor mutants in Xenopus oocytes: correlation between transcriptional activity and ability to form protein-DNA complexes.

1988 • 42 citations

Two regions of the mouse mammary tumor virus long terminal repeat regulate the activity of its promoter in mammary cell lines.

1991 • 33 citations

Assembly of MMTV promoter minichromosomes with positioned nucleosomes precludes NF1 access but not restriction enzyme cleavage

1998 • 32 citations

Characterization of a chromatin remodelling activity in Xenopus oocytes

1999 • 25 citations

Inhibition of chromatin assembly in Xenopus oocytes correlates with derepression of the mouse mammary tumor virus promoter.

1991 • 24 citations

Characterization of an NF-1/CTF Family Member as a Functional Activator of the Mouse Mammary Tumor Virus Long Terminal Repeat 5′ Enhancer

1996 • 21 citations