Proteasome-mediated degradation of transcriptional activators correlates with activation domain potency in vivo

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

STATs and Gene Regulation

1997 • 3,927 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

1998 • 1,870 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

1998 • 1,483 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

Transcriptional activation by recruitment

1997 • 1,163 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

The general transcription factors of RNA polymerase II.

1996 • 1,010 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of Yeast

1986 • 946 citations

The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

1991 • 805 citations

Negative effect of the transcriptional activator GAL4

1988 • 672 citations

DNA recognition by GAL4: structure of a protein-DNA complex

1992 • 664 citations

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

1994 • 644 citations

In vivo ubiquitination and proteasome-mediated degradation of p53(1).

1996 • 643 citations

Proteasome-dependent degradation of the human estrogen receptor

1999 • 573 citations

A humanized system for pharmacologic control of gene expression

1996 • 533 citations

Critical Structural Elements of the VP16 Transcriptional Activation Domain

1991 • 461 citations

Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains

1992 • 446 citations

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.

1995 • 438 citations

Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

1996 • 405 citations

A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice.

1995 • 383 citations

The SWI-SNF complex: a chromatin remodeling machine?

1995 • 379 citations

Structure and function of transcriptional activation domains

1995 • 376 citations

Rel/NF-κB and IκB proteins: an overview

1997 • 372 citations

RNA Polymerase II Holoenzyme Contains SWI/SNF Regulators Involved in Chromatin Remodeling

1996 • 364 citations

Reduced binding of TFIID to transcriptionally compromised mutants of VP16

1991 • 362 citations

Different activation domains stimulate transcription from remote (‘enhancer’) and proximal (‘promoter’) positions.

1992 • 359 citations

Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential

1997 • 338 citations

Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: Evidence for transcriptional adaptors

1990 • 312 citations

Eukaryotic activators function during multiple steps of preinitiation complex assembly

1993 • 311 citations

Cyclin Ubiquitination: The destructive end of mitosis

1995 • 304 citations

The 65-kDa subunit of human NF-kappa B functions as a potent transcriptional activator and a target for v-Rel-mediated repression.

1992 • 288 citations

Induced α Helix in the VP16 Activation Domain upon Binding to a Human TAF

1997 • 286 citations

Three Functional Classes of Transcriptional Activation Domains

1996 • 267 citations

Contact with a component of the polymerase II holoenzyme suffices for gene activation

1995 • 262 citations

Selective protein degradation: A journey's end within the proteasome

1995 • 259 citations

The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP.

1988 • 245 citations

Heat Shock Response and Protein Degradation: Regulation of HSF2 by the Ubiquitin-Proteasome Pathway

1998 • 206 citations

An Activator Target in the RNA Polymerase II Holoenzyme

1998 • 195 citations

Quantitation of putative activator-target affinities predicts transcriptional activating potentials.

1996 • 195 citations

Connecting a promoter-bound protein to TBP bypasses the need for a transcriptional activation domain

1995 • 188 citations

GAL4 Interacts with TATA-Binding Protein and Coactivators

1995 • 164 citations

Proteolysis by Calpains: a Possible Contribution to Degradation of p53

1997 • 162 citations

Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevisiae.

1992 • 162 citations

Stimulation of RNA polymerase II transcription initiation by recruitment of TBP in vivo

1995 • 161 citations

Chromatin Structure and RNA Polymerase II Connection: Implications for Transcription

1996 • 159 citations

Gene activation by recruitment of the RNA polymerase II holoenzyme.

1996 • 123 citations

Activator-Mediated Recruitment of the RNA Polymerase II Machinery Is the Predominant Mechanism for Transcriptional Activation in Yeast

1998 • 118 citations

Basal promoter elements as a selective determinant of transcriptional activator function

1995 • 116 citations

Recruiting TATA-Binding Protein to a Promoter: Transcriptional Activation without an Upstream Activator

1995 • 108 citations

Mutational analysis of the transcription activation domain of RelA: identification of a highly synergistic minimal acidic activation module.

1994 • 104 citations

Ubiquitination of RNA polymerase II large subunit signaled by phosphorylation of carboxyl-terminal domain

1999 • 99 citations

Proteasome Activation Occurs at an Early, Premitochondrial Step of Thymocyte Apoptosis

1998 • 90 citations

Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor

1995 • 89 citations

YY1 Facilitates the Association of Serum Response Factor with the c-fos Serum Response Element

1995 • 86 citations

Modulation of promoter occupancy by cooperative DNA binding and activation-domain function is a major determinant of transcriptional regulation by activators in vivo.

1996 • 80 citations

JAKs, STATs and signal transduction in response to the interferons and other cytokines

1996 • 71 citations

The Oct-2 glutamine-rich and proline-rich activation domains can synergize with each other or duplicates of themselves to activate transcription.

1994 • 70 citations

Expression cloning of a novel zinc finger protein that binds to the c-fos serum response element.

1992 • 63 citations

Activation of Transcription In Vitro by Recruitment of the Yeast RNA Polymerase II Holoenzyme

1998 • 37 citations