Inactivation of isocitrate dehydrogenase by phosphorylation is mediated by the negative charge of the phosphate.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing

1984 • 4,231 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

Culture Medium for Enterobacteria

1974 • 3,002 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Chemical and biological evolution of a nucleotide-binding protein

1974 • 1,457 citations

pEMBL: a new family of single stranded plasmids

1983 • 1,231 citations

Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase.

1977 • 844 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, X. REGULATION OF THE ACTIVITY OF THE PYRUVATE DEHYDROGENASE COMPLEX FROM BEEF KIDNEY MITOCHONDRIA BY PHOSPHORYLATION AND DEPHOSPHORYLATION

1969 • 669 citations

The role and control of the glyoxylate cycle in Escherichia coli

1966 • 594 citations

Phosphorylation of Isocitrate Dehydrogenase of Escherichia coli

1979 • 238 citations

A polymer-dependent increase in phosphorylation of beta-tubulin accompanies differentiation of a mouse neuroblastoma cell line.

1985 • 237 citations

A protein with kinase and phosphatase activities involved in regulation of tricarboxylic acid cycle

1982 • 212 citations

High guanine plus cytosine content in the third letter of codons of an extreme thermophile. DNA sequence of the isopropylmalate dehydrogenase of Thermus thermophilus.

1984 • 207 citations

Substrate specificity of the cyclic AMP-dependent protein kinase.

1975 • 198 citations

Phosphorylation of isocitrate dehydrogenase as a demonstration of enhanced sensitivity in covalent regulation

1983 • 192 citations

Further Studies on the Site Phosphorylated in the Phosphorylase b to a Reaction^*

1964 • 172 citations

Compensatory phosphorylation of isocitrate dehydrogenase. A mechanism for adaptation to the intracellular environment.

1985 • 139 citations

1 The Enzymology of Control by Phosphorylation

1986 • 98 citations

Glycogen phosphorylase structures and function

1982 • 62 citations

Phosphorylase kinase specificity. A comparative study with cAMP-dependent protein kinase on synthetic peptides and peptide analogs of glycogen synthase and phosphorylase.

1982 • 41 citations

Significance of phosphorylation of phosphofructokinase.

1983 • 35 citations

Amino acid sequence round the site of phosphorylation in isocitrate dehydrogenase from Escherichia coli ML308

1984 • 33 citations

A comparison of the phosphorylated and unphosphorylated forms of isocitrate dehydrogenase from Escherichia coli ML308

1984 • 24 citations