Aberrant Stress-induced Phosphorylation of Perikaryal Neurofilaments

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

1979 • 2,285 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ.

1983 • 1,162 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons.

1975 • 937 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

1993 • 550 citations

Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis

1993 • 549 citations

Organization of mammalian neurofilament polypeptides within the neuronal cytoskeleton.

1984 • 496 citations

Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats

1987 • 490 citations

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1992 • 480 citations

Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis

1995 • 464 citations

Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis

1994 • 458 citations

Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

1994 • 456 citations

Multisite and hierarchal protein phosphorylation

1991 • 419 citations

Identification of the major multiphosphorylation site in mammalian neurofilaments.

1988 • 394 citations

Neurofilaments are obligate heteropolymers in vivo

1993 • 387 citations

Multiple phosphorylation sites in mammalian neurofilament polypeptides.

1982 • 381 citations

Neurofilament architecture combines structural principles of intermediate filaments with carboxy-terminal extensions increasing in size between triplet proteins.

1983 • 361 citations

A mutant neurofilament subunit causes massive, selective motor neuron death: Implications for the pathogenesis of human motor neuron disease

1994 • 356 citations

Aberrant neurofilament phosphorylation in Alzheimer disease.

1985 • 339 citations

The distribution of phosphorylation sites among identified proteolytic fragments of mammalian neurofilaments.

1983 • 291 citations

Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments

1993 • 270 citations

Intrinsic determinants of neuronal form and function

1989 • 264 citations

The structure and organization of the human heavy neurofilament subunit (NF-H) and the gene encoding it.

1988 • 234 citations

Neuronal Microtubules, Neurofilaments, and Microfilaments

1972 • 232 citations

Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.

1992 • 230 citations

Structure of the peripheral domains of neurofilaments revealed by low angle rotary shadowing

1988 • 230 citations

Neurofilament deficiency in quail caused by nonsense mutation in neurofilament-L gene.

1993 • 226 citations

cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization.

1993 • 207 citations

Neurofilaments: structure, metabolism and implications in disease.

1987 • 202 citations

Phosphorylation of Neurofilaments Is Altered in Amyotrophic Lateral Sclerosis

1988 • 198 citations

Reactivity of a panel of neurofilament antibodies on phosphorylated and dephosphorylated neurofilaments.

1986 • 179 citations

Multiple phosphorylated variants of the high molecular mass subunit of neurofilaments in axons of retinal cell neurons: characterization and evidence for their differential association with stationary and moving neurofilaments.

1988 • 177 citations

Neurofilaments

1987 • 166 citations

Neurofibrillary axonal swellings and amyotrophic lateral sclerosis

1984 • 164 citations

The Regulation of Neurofilament Protein Dynamics by Phosphorylation: Clues to Neurofibrillary Pathobiology

1993 • 164 citations

Neurofilament Accumulation Induced in Synapses by Leupeptin

1983 • 154 citations

Activation of Protein Kinase Cascades by Osmotic Shock

1995 • 154 citations

Transcriptional and post-transcriptional effects of nerve growth factor on expression of the three neurofilament subunits in PC-12 cells.

1988 • 153 citations

Phosphorylation of neurofilament proteins and chromatolysis following transection of rat sciatic nerve

1987 • 143 citations

Two novel kinases phosphorylate tau and the KSP site of heavy neurofilament subunits in high stoichiometric ratios

1991 • 134 citations

Cytotypic differences in the protein composition of the axonally transported cytoskeleton in mammalian neurons

1987 • 130 citations

GTPase-Deficient Gα₁₆ and Gα_q Induce PC12 Cell Differentiation and Persistent Activation of cJun NH₂-Terminal Kinases

1996 • 123 citations

Phosphorylated high molecular weight neurofilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells

1990 • 118 citations

Purification and Characterization of a Z-Leu-Leu-Leu-MCA Degrading Protease Expected to Regulate Neurite Formation: A Novel Catalytic Activity in Proteasome

1993 • 117 citations

Sequence and structure of the mouse gene coding for the largest neurofilament subunit

1988 • 109 citations

Amyotrophic lateral sclerosis is a multifactorial disease

1995 • 99 citations

Dephosphorylation-induced interactions of neurofilaments with microtubules.

1990 • 88 citations

Transfected rat high-molecular-weight neurofilament (NF-H) coassembles with vimentin in a predominantly nonphosphorylated form

1990 • 88 citations

Phosphorylation of bovine neurofilament proteins by protein kinase FA (glycogen synthase kinase 3)

1991 • 86 citations

A molecular dissection of the carboxyterminal tails of the major neurofilament subunits NF‐M and NF‐H

1991 • 84 citations

Identification of Endogenously Phosphorylated KSP Sites in the High‐Molecular‐Weight Rat Neurofilament Protein

1994 • 82 citations

Early posttranslational modifications of the three neurofilament subunits in mouse retinal ganglion cells: neuronal sites and time course in relation to subunit polymerization and axonal transport

1989 • 79 citations

Oxidative stress: its role in the pathogenesis of amyotrophic lateral sclerosis

1995 • 75 citations

Posttranslational modification of neurofilament polypeptides in rabbit retina

1987 • 69 citations

Phosphorylation-related immunoreactivity and the rate of transport of neurofilaments in chronic 2,5-hexanedione intoxication

1991 • 65 citations

Age-associated and cell-type-specific neurofibrillary pathology in transgenic mice expressing the human midsized neurofilament subunit

1994 • 63 citations

Stress activated protein kinases, a novel family of mitogen-activated protein kinases, are heterogeneously expressed in the adult rat brain and differentially distributed from extracellular-signal-regulated protein kinases

1995 • 47 citations

A role for neurofilaments in the pathogenesis of amyotrophic lateral sclerosis

1995 • 46 citations

Characterization of a shared epitope in cortical Lewy body fibrils and Alzheimer paired helical filaments

1994 • 42 citations

Cross-linked collagen surface for cell culture that is stable, uniform, and optically superior to conventional surfaces

1985 • 38 citations

The Neurite-Initiating Effect of a Tripeptide Aldehyde Protease Inhibitor on PC12h Cells

1989 • 27 citations

Specificity of calcium-activated neutral proteinase (CANP) inhibitors for human ?CANP and mCANP

1993 • 22 citations

Phosphatase Resistance of ERK2 Brain Kinase PK40^erk2

1995 • 21 citations

Evidence that the monoclonal antibodies SMI-31 and SMI-34 recognize different phosphorylation-dependent epitopes of the murine high molecular mass neurofilament subunit

1993 • 16 citations

Increased phosphorylation of neurofilament subunits in PC12 cells and rat dorsal root ganglion neurons treated with N‐Acetyl‐Leu‐Leu‐norleucinal

1995 • 8 citations