Glucocorticoids Suppress Tumor Necrosis Factor-α Expression by Human Monocytic THP-1 Cells by Suppressing Transactivation through Adjacent NF-κB and c-Jun-Activating Transcription Factor-2 Binding Sites in the Promoter

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease

1997 • 3,152 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

1995 • 1,311 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

1998 • 1,218 citations

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.

1994 • 1,057 citations

The −308 tumor necrosis factor-α promoter polymorphism effects transcription

1997 • 868 citations

Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors

1995 • 815 citations

CD14 Is a pattern recognition receptor

1994 • 706 citations

Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction.

1993 • 530 citations

Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.

1990 • 509 citations

The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation

1990 • 507 citations

Jun N-Terminal Kinase/Stress-Activated Protein Kinase (JNK/SAPK) Is Required for Lipopolysaccharide Stimulation of Tumor Necrosis Factor Alpha (TNF-α) Translation: Glucocorticoids Inhibit TNF-α Translation by Blocking JNK/SAPK

1997 • 497 citations

Lipopolysaccharide Induction of the Tumor Necrosis Factor-α Promoter in Human Monocytic Cells

1997 • 466 citations

Role of tumor necrosis factor-α in disease states and inflammation

1993 • 415 citations

Cross-Talk between Nuclear Factor-κB and the Steroid Hormone Receptors: Mechanisms of Mutual Antagonism

1998 • 405 citations

Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein.

1993 • 380 citations

Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism

1998 • 339 citations

Tumor Necrosis Factor: The molecules and Their Emerging Role in Medicine

1992 • 330 citations

Integration of Rac-dependent Regulation of Cyclin D1 Transcription through a Nuclear Factor-κB-dependent Pathway

1999 • 289 citations

Tumor Necrosis Factor Alpha Gene Regulation in Activated T Cells Involves ATF-2/Jun and NFATp

1996 • 252 citations

Human tumor necrosis factor alpha gene regulation by virus and lipopolysaccharide.

1990 • 236 citations

A Nuclear Factor for Interleukin-6 Expression (NF-IL6) and the Glucocorticoid Receptor Synergistically Activate Transcription of the Rat α1-Acid Glycoprotein Gene via Direct Protein-Protein Interaction

1993 • 215 citations

Effects of estrogens and antiestrogens on estrogen receptor dynamics and the induction of progesterone receptor in MCF-7 human breast cancer cells.

1982 • 212 citations

The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines.

1992 • 210 citations

Inhibition by glucocorticoids of the formation of interleukin-1 alpha, interleukin-1 beta, and interleukin-6: mediation by decreased mRNA stability.

1993 • 202 citations

Cell-Type-Specific Regulation of the Human Tumor Necrosis Factor Alpha Gene in B Cells and T Cells by NFATp and ATF-2/JUN

1996 • 189 citations

A Striking Similarity in the Organization of the E-Selectin and Bate Interferon gene Promoters

1994 • 187 citations

Relative Contribution of Transcription and Translation to the Induction of Tumor Necrosis Factor-α by Lipopolysaccharide

1998 • 175 citations

C/EBP beta regulation of the tumor necrosis factor alpha gene.

1994 • 173 citations

Cooperativity between two NF-kappa B complexes, mediated by high-mobility-group protein I(Y), is essential for cytokine-induced expression of the E-selectin promoter.

1994 • 159 citations

Interactive effects of the tumor necrosis factor promoter and 3'-untranslated regions.

1991 • 153 citations

Monocyte Expression of the Human Prointerleukin 1β Gene (IL1B) Is Dependent on Promoter Sequences Which Bind the Hematopoietic Transcription Factor Spi-1/PU.1

1995 • 149 citations

Transcriptional activation of the human TNF-alpha promoter by superantigen in human monocytic cells: role of NF-kappa B.

1995 • 146 citations

Tumor necrosis factors: The molecules and their emerging role in medicine

1992 • 138 citations

Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-α gene

1994 • 125 citations

Complex NF-κB Interactions at the Distal Tumor Necrosis Factor Promoter Region in Human Monocytes

1998 • 122 citations

Conserved kappa B element located downstream of the tumor necrosis factor alpha gene: distinct NF-kappa B binding pattern and enhancer activity in LPS activated murine macrophages.

1995 • 119 citations

Ischemia and Reperfusion Enhance ATF-2 and c-Jun Binding to cAMP Response Elements and to an AP-1 Binding Site from the c-jun Promoter

1995 • 118 citations

Glucocorticoid modulation of human monocyte/macrophage function: Control of TNF-α secretion

1997 • 117 citations

Tumor Necrosis Factor Alpha Gene Regulation: Enhancement of C/EBPβ-Induced Activation by c-Jun

1998 • 117 citations

Regulation of the Human TNF Promoter by the Transcription Factor Ets

1995 • 116 citations

Altering the specificity of signal transduction cascades: positive regulation of c-Jun transcriptional activity by protein kinase A.

1994 • 93 citations

Multiple sclerosis: TNF revisited, with promise

1995 • 88 citations

Identification of a tumor necrosis factor-responsive element in the tumor necrosis factor alpha gene

1991 • 86 citations

An in vitro transcription analysis of early responses of the human immunodeficiency virus type 1 long terminal repeat to different transcriptional activators.

1991 • 83 citations

Cytokines (Immunoinflammatory Hormones) and Their Natural Regulation in Inflammatory Bowel Disease (Crohn’s Disease and Ulcerative Colitis): A Review

1994 • 76 citations

The fate of pro-TNF-alpha following inhibition of metalloprotease-dependent processing to soluble TNF-alpha in human monocytes.

1997 • 68 citations

The essential role of the UA-rich sequence in endotoxin-induced cachectin/TNF synthesis.

1990 • 67 citations

Preparation and Characterization of Monoclonal Antibodies Directed Against Antigenic Determinants of Recombinant Human Tumour Necrosis Factor (rTNF)

1987 • 63 citations

Microbial superantigens induce NF-kappa B in the human monocytic cell line THP-1.

1993 • 55 citations

Expression of c-jun protooncogene in human myelomonocytic cells

1989 • 54 citations

Dexamethasone attenuates NF-κ B DNA binding activity without inducing I κ B levels in rat brain in vivo

1997 • 49 citations

Suppression of human monocyte tumour necrosisfactor-alpharelease by glucocorticoid therapy: relationshipto systemic monocytopaenia and cortisol suppression

1997 • 43 citations

CCAAT/ENHANCER BINDING PROTEIN IS INVOLVED IN THE EXPRESSION OF THE TUMOUR NECROSIS FACTOR GENE IN HUMAN MONOCYTES

1996 • 42 citations

Dexamethasone Antagonizes IL-4 and IL-10-Induced Release of IL-IRA by Monocytes but Augments IL-4-, IL-10-, and TGF-β-Induced Suppression of TNF-α Release

1996 • 41 citations

Cytomegalovirus modulates transcription factors necessary for the activation of the tumor necrosis factor-alpha promoter.

1997 • 40 citations

Suppression of human monocyte tumour necrosisfactor-alpharelease by glucocorticoid therapy: relationshipto systemic monocytopaenia and cortisol suppression

1997 • 30 citations

Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-4 Differentially Regulate the Human Tumor Necrosis Factor-α Promoter Region

1995 • 26 citations

Glucocorticoid Receptor mRNA Expression in Pulmonary Alveolar Macrophages in Sarcoidosis

1991 • 6 citations