Monocyte Expression of the Human Prointerleukin 1β Gene (IL1B) Is Dependent on Promoter Sequences Which Bind the Hematopoietic Transcription Factor Spi-1/PU.1

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene

1990 • 993 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation

1990 • 507 citations

The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites.

1990 • 450 citations

A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells

1986 • 408 citations

The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor.

1994 • 407 citations

cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription.

1991 • 388 citations

PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity.

1992 • 362 citations

Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain

1993 • 345 citations

Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus

1984 • 341 citations

The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB.

1993 • 317 citations

The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter.

1993 • 315 citations

Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6

1992 • 299 citations

Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation

1993 • 278 citations

Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene

1986 • 205 citations

PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer.

1993 • 188 citations

The human prointerleukin 1 beta gene requires DNA sequences both proximal and distal to the transcription start site for tissue-specific induction.

1993 • 180 citations

Cell-Specific Expression of the Macrophage Scavenger Receptor Gene Is Dependent on PU.l and a Composite AP-l/ets Motif

1994 • 164 citations

Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin 1 beta gene.

1994 • 156 citations

Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis.

1993 • 152 citations

Regulation of the interleukin-1 beta (IL-1 beta) gene by mycobacterial components and lipopolysaccharide is mediated by two nuclear factor-IL6 motifs.

1993 • 131 citations

Ets-related protein PU.1 regulates expression of the immunoglobulin J-chain gene through a novel Ets-binding element.

1993 • 129 citations

A purine-rich DNA sequence motif present in SV40 and lymphotropic papovavirus binds a lymphoid-specific factor and contributes to enhancer activity in lymphoid cells.

1987 • 110 citations

PU.1 and an HLH family member contribute to the myeloid-specific transcription of the Fc gamma RIIIA promoter.

1994 • 90 citations

A CRE/ATF-Like Site in the Upstream Regulatory Sequence of the Human Interleukin 1β Gene Is Necessary for Induction in U937 and THP-1 Monocytic Cell Lines

1993 • 85 citations

Synergism between protein‐kinase C and cAMP‐dependent pathways in the expression of the interleukin‐1β gene is mediated via the activator‐protein‐1 (AP‐1) enhancer activity

1993 • 81 citations

Monokines and Other Non-Lymphocytic Cytokines

1989 • 75 citations

Detection of Two Tissue-Specific DNA-Binding Proteins with Affinity for Sites in the Mouse β-Globin Intervening Sequence 2

1988 • 66 citations

The functional importance of a cap site-proximal region of the human prointerleukin 1 beta gene is defined by viral protein trans-activation.

1992 • 60 citations

An inducible enhancer controls the expression of the human interleukin 1 beta gene.

1990 • 45 citations

Human IL-1 receptor antagonist promoter. Cell type-specific activity and identification of regulatory regions.

1992 • 41 citations

The PU.1/Spi-1 proto-oncogene is a transcriptional regulator of a lentivirus promoter

1993 • 40 citations

The NF-beta A-binding element, not an overlapping NF-IL-6-binding element, is required for maximal IL-1 beta gene expression.

1994 • 40 citations

Isolation and Characterization of Human Interleukin-1 mRNA by Molecular Cloning

1985 • 5 citations