Potential roles for focal adhesion kinase in development

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Integrins and anoikis

1997 • 1,145 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

1992 • 811 citations

MOLECULAR AND FUNCTIONAL ANALYSIS OF CADHERIN-BASED ADHERENS JUNCTIONS

1997 • 800 citations

Cell-to-substrate contacts in living fibroblasts: an interference reflexion study with an evaluation of the technique

1976 • 705 citations

Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors.

1995 • 619 citations

Signals for death and survival: A two-step mechanism for cavitation in the vertebrate embryo

1995 • 601 citations

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

1996 • 595 citations

Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation.

1996 • 514 citations

The Molecular Architecture of Focal Adhesions

1995 • 479 citations

Integrin signaling: specificity and control of cell survival and cell cycle progression

1997 • 474 citations

Focal adhesion kinase (p125FAK): A point of convergence in the action of neuropeptides, integrins, and oncogenes

1992 • 453 citations

Evidence for In Vivo Phosphorylation of the Grb2 SH2-Domain Binding Site on Focal Adhesion Kinase by Src-Family Protein-Tyrosine Kinases

1996 • 450 citations

Cleavage of Focal Adhesion Kinase by Caspases during Apoptosis

1997 • 338 citations

Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells.

1994 • 320 citations

Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated.

1991 • 310 citations

The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

1998 • 290 citations

Signal transduction through integrins: A central role for focal adhesion kinase?

1995 • 273 citations

Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells.

1996 • 265 citations

Focal adhesion kinase: at the crossroads of signal transduction

1997 • 260 citations

Caspase-mediated Cleavage of Focal Adhesion Kinase pp125FAK and Disassembly of Focal Adhesions in Human Endothelial Cell Apoptosis

1998 • 258 citations

A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA.

1996 • 250 citations

Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50CSK in human metastatic prostate carcinoma

1996 • 231 citations

Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK.

1995 • 218 citations

Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells.

1994 • 214 citations

Programmed Cell Death in Development

1995 • 201 citations

Mesodermal defects and cranial neural crest apoptosis in α5 integrin-null embryos

1997 • 193 citations

Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK

1993 • 192 citations

Genistein-Induced Apoptosis of Prostate Cancer Cells is Preceded by a Specific Decrease in Focal Adhesion Kinase Activity

1997 • 186 citations

Induction of Apoptosis after Expression of PYK2, a Tyrosine Kinase Structurally Related to Focal Adhesion Kinase

1997 • 167 citations

Tyrosine Phosphorylation of Paxillin and Focal Adhesion Kinase during Insulin-like Growth Factor-I-stimulated Lamellipodial Advance

1997 • 144 citations

Tyrosine phosphorylation of the focal adhesion kinase pp125FAK during development: relation to paxillin

1993 • 139 citations

Differential Regulation of Pyk2 and Focal Adhesion Kinase (FAK)

1998 • 137 citations

Tyrosine phosphorylation of membrane proteins mediates cellular invasion by transformed cells.

1992 • 136 citations

Targeted proteolysis of the focal adhesion kinase pp125 FAK during c-MYC-induced apoptosis is suppressed by integrin signalling.

1996 • 128 citations

A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer

1997 • 123 citations

Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II

1994 • 122 citations

Focal Adhesion Kinase (p125FAK) Expression Correlates with Motility of Human Melanoma Cell Lines

1995 • 111 citations

Potential role for focal adhesion kinase in migrating and proliferating keratinocytes near epidermal wounds and in culture.

1994 • 100 citations

Focal adhesion kinase

1997 • 99 citations

Integrin-dependent adhesive activity is spatially controlled by inductive signals at gastrulation

1996 • 86 citations

v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts.

1995 • 83 citations

Protein kinase C regulates tyrosine phosphorylation of pp125FAK in platelets adherent to fibrinogen

1996 • 79 citations

The focal adhesion kinase

1996 • 78 citations

Molecular Analysis and Developmental Expression of the Focal Adhesion Kinase pp125FAK in Xenopus laevis

1995 • 77 citations

Impairment of Mobility in Endodermal Cells by FAK Deficiency

1996 • 71 citations

Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosis

1997 • 65 citations

The molecular basis for the assembly and modulation of adherens-type junctions

1990 • 62 citations

Focal Adhesion Kinase Is Not Essential for in Vitro and in Vivo Differentiation of ES Cells

1995 • 57 citations

Mesoderm Migration in the Early Chick Embryo

1986 • 39 citations

pp125FAK in Human Melanocytes and Melanoma: Expression and Phosphorylation

1995 • 37 citations

Cloning of a Xenopus laevis cDNA encoding focal adhesion kinase (FAK) and expression during early development

1995 • 35 citations

Alterations in focal adhesion and cytoskeletal proteins during apoptosis.

1998 • 25 citations

The cell surface in embryogenesis and carcinogenesis

1989 • 22 citations

Interactions between mesoderm cells and the extracellular matrix following gastrulation in the chick embryo

1991 • 21 citations

Restricted expression of cell adhesion kinase-beta in rat tissues.

1997 • 19 citations

Down-regulation of focal adhesion kinase, pp125FAK, in endothelial cell retraction during tumor cell invasion.

1998 • 7 citations