Function of N-Terminal Transactivation Domain of the Estrogen Receptor Requires a Potential α-Helical Structure and Is Negatively Regulated by the A Domain

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1997 • 2,100 citations

Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

1995 • 1,973 citations

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

1999 • 1,965 citations

Nuclear Receptor Coregulators: Cellular and Molecular Biology*

1999 • 1,783 citations

Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*

1997 • 1,678 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid

1995 • 1,085 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

A structural role for hormone in the thyroid hormone receptor

1995 • 938 citations

Cloning, Chromosomal Localization, and Functional Analysis of the Murine Estrogen Receptor β

1997 • 862 citations

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

1990 • 772 citations

Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site

1983 • 667 citations

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.

1994 • 649 citations

Coactivator and Corepressor Regulation of the Agonist/Antagonist Activity of the Mixed Antiestrogen, 4-Hydroxytamoxifen

1997 • 640 citations

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

1990 • 617 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

Mechanism of action of an acidic transcriptional activator in vitro

1991 • 557 citations

Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element

1989 • 507 citations

Deciphering protein sequence information through hydrophobic cluster analysis (HCA): current status and perspectives

1997 • 473 citations

Critical Structural Elements of the VP16 Transcriptional Activation Domain

1991 • 461 citations

Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.

1994 • 460 citations

Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region.

1993 • 451 citations

The Steroid Receptor Coactivator-1 Contains Multiple Receptor Interacting and Activation Domains That Cooperatively Enhance the Activation Function 1 (AF1) and AF2 Domains of Steroid Receptors

1998 • 421 citations

Ligand binding was acquired during evolution of nuclear receptors

1997 • 407 citations

Estrogen Receptors: Bioactivities and Interactions with Cell Signaling Pathways1

1996 • 379 citations

Binding of general transcription factor TFIIB to an acidic activating region

1991 • 377 citations

Interaction between the Amino- and Carboxyl-terminal Regions of the Rat Androgen Receptor Modulates Transcriptional Activity and Is Influenced by Nuclear Receptor Coactivators

1997 • 370 citations

Distinct classes of transcriptional activating domains function by different mechanisms

1990 • 368 citations

Estrogen Receptor Activation Function 1 Works by Binding p160 Coactivator Proteins

1998 • 366 citations

Purification and Identification of p68 RNA Helicase Acting as a Transcriptional Coactivator Specific for the Activation Function 1 of Human Estrogen Receptor α

1999 • 359 citations

Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

1992 • 354 citations

Estrogens and breast cancer

1996 • 343 citations

Transcription in yeast activated by a putative amphipathic α helix linked to a DNA binding unit

1987 • 324 citations

Stimulation of RARα Activation Function AF-1 through Binding to the General Transcription Factor TFIIH and Phosphorylation by CDK7

1997 • 307 citations

Induced α Helix in the VP16 Activation Domain upon Binding to a Human TAF

1997 • 286 citations

Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins

1999 • 274 citations

Steroid receptor induction of gene transcription: A two-step model

1997 • 269 citations

The N-terminal DNA-binding ‘zinc finger’ of the oestrogen and glucocorticoid receptors determines target gene specificity.

1988 • 265 citations

Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain.

1993 • 249 citations

Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells

1995 • 230 citations

Different Regions in Activation Function-1 of the Human Estrogen Receptor Required for Antiestrogen- and Estradiol-dependent Transcription Activation

1996 • 214 citations

Ligand-dependent, transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor.

1995 • 209 citations

Potentiation of Human Estrogen Receptor α Transcriptional Activation through Phosphorylation of Serines 104 and 106 by the Cyclin A-CDK2 Complex

1999 • 200 citations

Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast.

1993 • 186 citations

A Nuclear Receptor Corepressor Modulates Transcriptional Activity of Antagonist-Occupied Steroid Hormone Receptor

1998 • 168 citations

Hormone-Dependent Interaction between the Amino- and Carboxyl-Terminal Domains of Progesterone Receptor in Vitro and in Vivo

1999 • 167 citations

Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor.

1994 • 165 citations

p300 Mediates Functional Synergism between AF-1 and AF-2 of Estrogen Receptor α and β by Interacting Directly with the N-terminal A/B Domains

2000 • 154 citations

Detection of secondary structure elements in proteins by hydrophobic cluster analysis

1992 • 148 citations

An N-terminal Inhibitory Function, IF, Suppresses Transcription by the A-isoform but Not the B-isoform of Human Progesterone Receptors

1998 • 145 citations

Dominant Activity of Activation Function 1 (AF-1) and Differential Stoichiometric Requirements for AF-1 and -2 in the Estrogen Receptor α-β Heterodimeric Complex

1999 • 138 citations

Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast.

1992 • 116 citations

Different positioning of the ligand-binding domain helix 12and the F domain of the estrogen receptor accounts for functional differences between agonists and antagonists

1998 • 109 citations

Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast

1992 • 103 citations

Interdomain Signaling in a Two-domain Fragment of the Human Glucocorticoid Receptor

1999 • 102 citations

Function of Nuclear Co-repressor Protein on Thyroid Hormone Response Elements Is Regulated by the Receptor A/B Domain

1996 • 101 citations

Identification of a Third Autonomous Activation Domain within the Human Estrogen Receptor

1997 • 101 citations

Structure and Function of Estrogen Receptors

1995 • 100 citations

Functional Interactions between the Estrogen Receptor and DRIP205, a Subunit of the Heteromeric DRIP Coactivator Complex

2000 • 97 citations

Two Estrogen Receptor (ER) Isoforms with Different Estrogen Dependencies Are Generated from the Trout ER Gene1

2000 • 94 citations

Differential Functional Activities of Rainbow Trout and Human Estrogen Receptors Expressed in the Yeast Saccharomyces cerevisiae

1995 • 85 citations

Involvement of the Transcription Factor IID Protein Complex in Gene Activation by the N-Terminal Transactivation Domain of the Glucocorticoid Receptorin Vitro

1997 • 85 citations

Estrogen Receptor Domains E and F: Role in Dimerization and Interaction with Coactivator RIP-140

1999 • 79 citations

Hormone binding and transcription activation by estrogen receptors: Analyses using mammalian and yeast systems

1993 • 75 citations

Identification of charged residues in an N-terminal portion of the hormone-binding domain of the human estrogen receptor important in transcriptional activity of the receptor.

1993 • 71 citations

Steroid and nuclear receptors Villefranche-sur-Mer, France, May 25–27, 1999

1999 • 70 citations

A nonnatural transcriptional coactivator

1997 • 60 citations

A Role for the Hsp40 Ydj1 in Repression of Basal Steroid Receptor Activity in Yeast

2000 • 54 citations

Two Functionally Different Protein Isoforms Are Produced from the Chicken Estrogen Receptor-α Gene

1999 • 51 citations

Overexpression of rainbow trout estrogen receptor domains in Escherichia coli: characterization and utilization in the production of antibodies for immunoblotting and immunocytochemistry

1994 • 51 citations

Synergism between a half‐site and an imperfect estrogen‐responsive element, and cooperation with COUP‐TFI are required for estrogen receptor (ER) to achieve a maximal estrogen‐stimulation of rainbow trout ER gene

1999 • 49 citations

Three-dimensional model for the hormone binding domains of steroid receptors.

1993 • 46 citations

Reappraisal of the Role of Heat Shock Proteins as Regulators of Steroid Receptor Activity

1998 • 46 citations

Phosphorylation of serine-167 on the human oestrogen receptor is important for oestrogen response element binding and transcriptional activation

1997 • 44 citations

Purification, Functional Characterization, and Crystallization of the Ligand Binding Domain of the Retinoid X Receptor

1995 • 37 citations

Use of the yeast one-hybrid system to screen for mutations in the ligand-binding domain of the estrogen receptor

1996 • 19 citations

Estrogen Receptor Residues Required for Stereospecific Ligand Recognition and Activation

1997 • 16 citations