Deciphering protein sequence information through hydrophobic cluster analysis (HCA): current status and perspectives

Basic local alignment search tool

1990 • 87,358 citations

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

The structure of proteins: Two hydrogen-bonded helical configurations of the polypeptide chain

1951 • 2,750 citations

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

1993 • 2,237 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes.

1990 • 1,542 citations

The crystal structure of the bacterial chaperonln GroEL at 2.8 Å

1994 • 1,322 citations

NMR structure of the mouse prion protein domain PrP(121–231)

1996 • 1,251 citations

Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid

1995 • 1,085 citations

Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein

1990 • 1,035 citations

One thousand families for the molecular biologist

1992 • 1,023 citations

A structural role for hormone in the thyroid hormone receptor

1995 • 938 citations

Neurotoxicity of a prion protein fragment

1993 • 937 citations

OB(oligonucleotide/oligosaccharide binding)-fold: common structural and functional solution for non-homologous sequences.

1993 • 917 citations

Similar Amino Acid Sequences: Chance or Common Ancestry?

1981 • 855 citations

Issues in searching molecular sequence databases

1994 • 781 citations

A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins

1997 • 750 citations

Emergence of Preferred Structures in a Simple Model of Protein Folding

1996 • 666 citations

Hydrophobic cluster analysis: An efficient new way to compare and analyse amino acid sequences

1987 • 616 citations

Growth retardation and tumour inhibition by BRCA1

1996 • 360 citations

Structural principles of the globular organization of protein chains. A stereochemical theory of globular protein secondary structure

1974 • 355 citations

Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein.

1991 • 352 citations

Three pure chaperone proteins of Escherichia coli--SecB, trigger factor and GroEL--form soluble complexes with precursor proteins in vitro.

1989 • 317 citations

Hydrophobic cluster analysis: procedures to derive structural and functional information from 2-D-representation of protein sequences

1990 • 300 citations

Detection of conserved segments in proteins: iterative scanning of sequence databases with alignment blocks.

1994 • 286 citations

Early events in preprotein recognition in E. coli: interaction of SRP and trigger factor with nascent polypeptides.

1995 • 276 citations

A ribosome-associated peptidyl-prolyl cis/trans isomerase identified as the trigger factor.

1995 • 273 citations

Trigger factor: a soluble protein that folds pro-OmpA into a membrane-assembly-competent form.

1987 • 257 citations

The Epstein-Barr Virus Nuclear Protein 2 Acidic Domain Forms a Complex with a Novel Cellular Coactivator That Can Interact with TFIIE

1995 • 246 citations

Escherichia coli trigger factor is a prolyl isomerase that associates with nascent polypeptide chains.

1996 • 244 citations

BEAUTY: an enhanced BLAST-based search tool that integrates multiple biological information resources into sequence similarity search results.

1995 • 229 citations

Cooperation of enzymatic and chaperone functions of trigger factor in the catalysis of protein folding

1997 • 203 citations

ProOmpA is stabilized for membrane translocation by either purified E. coli trigger factor or canine signal recognition particle

1988 • 196 citations

Tudor domains in proteins that interact with RNA

1997 • 192 citations

Conformational polymorphism of the amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein.

1994 • 186 citations

Structural symmetry of the extracellular domain of the Cytokine/Growth hormone/Prolactin receptor family and Interferon receptors revealed by Hydrophobic Cluster Analysis

1991 • 152 citations

Detection of secondary structure elements in proteins by hydrophobic cluster analysis

1992 • 148 citations

ProOmpA spontaneously folds in a membrane assembly competent state which trigger factor stabilizes.

1988 • 135 citations

Binary patterning of polar and nonpolar amino acids in the sequences and structures of native proteins

1995 • 130 citations

Trigger factor is involved in GroEL-dependent protein degradation in Escherichia coli and promotes binding of GroEL to unfolded proteins.

1995 • 106 citations

Solid‐state NMR studies of the prion protein H1 fragment

1996 • 83 citations

On the statistical significance of nucleic add similarities

1984 • 82 citations

Trigger factor, one of the Escherichia coli chaperone proteins, is an original member of the FKBP family

1995 • 82 citations

[18] Protein sequence comparison at genome scale

1996 • 81 citations

Identification of the prolyl isomerase domain of Escherichia coli trigger factor

1996 • 80 citations

Scores for sequence searches and alignments

1996 • 69 citations

Selection of a representative set of structures from brookhaven protein data bank

1992 • 58 citations

An 11.8 kDa proteolytic fragment of the E. coli trigger factor represents the domain carrying the peptidyl‐prolyl cis/trans isomerase activity

1996 • 56 citations

Three-dimensional model for the hormone binding domains of steroid receptors.

1993 • 46 citations

Interaction of some peroxisome proliferators with the mouse liver peroxisome proliferator-activated receptor (PPAR): a molecular modelling and quantitative structure-activity relationship (QSAR) study

1993 • 27 citations

Visual BLAST and Visual FASTA: graphic workbenches for interactive analysis of full BLAST and FASTA outputs under Microsoft Windows 95/NT

1997 • 23 citations

A simple tool to search for sequence motifs that are conserved in BLAST outputs

1994 • 22 citations

Common prevalence of alanine and glycine in mobile reactive centre loops of serpins and viral fusion peptides: Do prions possess a fusion peptide?

1994 • 22 citations

Hydrophobic Cluster Analysis Reveals a Third Chromodomain in theTetrahymenaPdd1p Protein of the Chromo Superfamily

1997 • 21 citations

Favored and suppressed patterns of hydrophobic and nonhydrophobic amino acids in protein sequences.

1993 • 18 citations

A comparison of several similarity indices used in the classification of protein sequences: a multivariate analysis

1992 • 17 citations

Structure of the hormone binding domain of human .beta.1 thyroid hormone nuclear receptor: Is it an .alpha./.beta. barrel?

1993 • 16 citations

Modern developments in molecular replacement

1996 • 14 citations

Predicting potential domain homologies from FASTA search results

1993 • 14 citations

Structural similarities between chaperone molecules of the HSP60 and HSP70 families deduced from hydrophobic cluster analysis

1994 • 11 citations

Redox mechanism for the chaperone activity of heat shock proteins HSPs 60, 70 and 90 as suggested by hydrophobic cluster analysis: hypothesis.

1994 • 8 citations

A molecular modelling study on the hormone binding site of the estrogen receptor.

1993 • 7 citations

Taxonomy of nuclear receptors and SERPINS by multivariate analysis of amino-acid composition

1996 • 6 citations

Putative dimeric organization of nuclear receptor hormone-binding domains, deduced from hydrophobic cluster analysis.

1994 • 4 citations