Chronic Nicotine Cell Specifically Upregulates Functional α4* Nicotinic Receptors: Basis for Both Tolerance in Midbrain and Enhanced Long-Term Potentiation in Perforant Path

The Mouse Brain in Stereotaxic Coordinates

2001 • 12,804 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory

2006 • 2,533 citations

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

1998 • 1,304 citations

Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System

2006 • 1,130 citations

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.

1992 • 858 citations

Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli

1996 • 826 citations

Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization

2004 • 685 citations

Synaptic Mechanisms Underlie Nicotine-Induced Excitability of Brain Reward Areas

2002 • 685 citations

Two types of neurone in the rat ventral tegmental area and their synaptic inputs.

1992 • 682 citations

Role of dopamine in the behavioural actions of nicotine related to addiction

2000 • 677 citations

Dramatic decreases in brain reward function during nicotine withdrawal

1998 • 676 citations

Opioid Receptors

2004 • 650 citations

Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei.

2001 • 640 citations

Molecular and Cellular Aspects of Nicotine Abuse

1996 • 605 citations

PRESYNAPTIC IONOTROPIC RECEPTORS AND THE CONTROL OF TRANSMITTER RELEASE

1999 • 578 citations

Neurobiological mechanisms in the transition from drug use to drug dependence

2003 • 575 citations

Molecular and Physiological Diversity of Nicotinic Acetylcholine Receptors in the Midbrain Dopaminergic Nuclei

2001 • 574 citations

Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors

1991 • 552 citations

Reduced antinociception in mice lacking neuronal nicotinic receptor subunits

1999 • 546 citations

Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors

2005 • 544 citations

Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment

1992 • 540 citations

The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?

2006 • 531 citations

Subunit Composition of Functional Nicotinic Receptors in Dopaminergic Neurons Investigated with Knock-Out Mice

2003 • 504 citations

Nicotinic Cholinergic Receptor Binding Sites in the Brain: Regulation in Vivo

1983 • 478 citations

Effects of chronic nicotine infusion on tolerance development and nicotinic receptors.

1983 • 455 citations

The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour

2004 • 439 citations

Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids

1989 • 426 citations

Subunit Composition and Pharmacology of Two Classes of Striatal Presynaptic Nicotinic Acetylcholine Receptors Mediating Dopamine Release in Mice

2004 • 409 citations

Electrophysiological Characterization of GABAergic Neurons in the Ventral Tegmental Area

1998 • 387 citations

Multi-Spectral Imaging and Linear Unmixing Add a Whole New Dimension to Laser Scanning Fluorescence Microscopy

2001 • 383 citations

Differential Desensitization and Distribution of Nicotinic Acetylcholine Receptor Subtypes in Midbrain Dopamine Areas

2003 • 363 citations

GABAA receptor-mediated inhibition of rat substantia nigra dopaminergic neurons by pars reticulata projection neurons

1995 • 356 citations

Immunohistochemical localization of neuronal nicotinic receptors in the rodent central nervous system

1987 • 350 citations

Properties and Opioid Inhibition of Mesolimbic Dopamine Neurons Vary according to Target Location

2006 • 329 citations

Reward prediction in primate basal ganglia and frontal cortex

1998 • 318 citations

Nicotine Acts as a Pharmacological Chaperone to Up-Regulate Human α4β2 Acetylcholine Receptors

2005 • 268 citations

Nicotine Induces Glutamate Release from Thalamocortical Terminals in Prefrontal Cortex

2003 • 259 citations

Nicotine Upregulates Its Own Receptors through Enhanced Intracellular Maturation

2005 • 255 citations

High-frequency stimulation in Parkinson's disease: more or less?

2005 • 243 citations

Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse.

2000 • 236 citations

Regulation of Nicotinic Acetylcholine Receptor Numbers and Function by Chronic Nicotine Exposure

2002 • 233 citations

Exposure to nicotine enhances the behavioral stimulant effect of nicotine and increases binding of [3H]acetylcholine to nicotinic receptors

1985 • 205 citations

Phenotypic Characterization of an α₄ Neuronal Nicotinic Acetylcholine Receptor Subunit Knock-Out Mouse

2000 • 202 citations

Acute and chronic nicotine exposure differentially facilitate the induction of LTP

1999 • 201 citations

The neurobiology of tobacco addiction

1991 • 200 citations

Chronic Nicotine Exposure Upregulates Nicotinic Receptors by a Novel Mechanism

2005 • 197 citations

Assembly of α4β2 Nicotinic Acetylcholine Receptors Assessed with Functional Fluorescently Labeled Subunits: Effects of Localization, Trafficking, and Nicotine-Induced Upregulation in Clonal Mammalian Cells and in Cultured Midbrain Neurons

2003 • 191 citations

Resolution of multiple green fluorescent protein color variants and dyes using two-photon microscopy and imaging spectroscopy

2001 • 183 citations

Dose‐related neuroprotective effects of chronic nicotine in 6‐hydroxydopamine treated rats, and loss of neuroprotection in α4 nicotinic receptor subunit knockout mice

2001 • 182 citations

Smoking and Parkinson’s disease in twins

2002 • 181 citations

Point mutant mice with hypersensitive α4 nicotinic receptors show dopaminergic deficits and increased anxiety

2001 • 180 citations

Differential changes in accumbens shell and core dopamine in behavioral sensitization to nicotine

2000 • 178 citations

In vivo nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57Bl/6J mice

2003 • 176 citations

Mechanisms underlying induction of long-term potentiation in rat medial and lateral perforant paths in vitro

1993 • 169 citations

Voltage-Gated Channels Block Nicotinic Regulation of CREB Phosphorylation and Gene Expression in Neurons

2001 • 157 citations

Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum

2001 • 154 citations

An autoradiographic analysis of cholinergic receptors in mouse brain after chronic nicotine treatment.

1991 • 152 citations

Involvement of the α3 Subunit in Central Nicotinic Binding Populations

2002 • 150 citations

Number, Density, and Surface/Cytoplasmic Distribution of GABA Transporters at Presynaptic Structures of Knock-In Mice Carrying GABA Transporter Subtype 1–Green Fluorescent Protein Fusions

2002 • 147 citations

Withdrawal from Chronic Nicotine Administration Impairs Contextual Fear Conditioning in C57BL/6 Mice

2005 • 145 citations

Rapsyn Escorts the Nicotinic Acetylcholine Receptor Along the Exocytic Pathway via Association with Lipid Rafts

2002 • 140 citations

Risk and protective factors for Parkinson's disease: A study in Swedish twins

2004 • 134 citations

Chronic nicotine and withdrawal effects on radial-arm maze performance in rats

1990 • 133 citations

Acute and long‐term changes in the mesolimbic dopamine pathway after systemic or local single nicotine injections

2002 • 132 citations

Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons

2006 • 131 citations

Expression of Nigrostriatal α6-Containing Nicotinic Acetylcholine Receptors Is Selectively Reduced, but Not Eliminated, by β3 Subunit Gene Deletion

2005 • 130 citations

Two pharmacologically distinct components of nicotinic receptor-mediated rubidium efflux in mouse brain require the beta2 subunit.

1999 • 129 citations

Chronic nicotine and mecamylamine treatment increase brain nicotinic receptor binding without changing alpha 4 or beta 2 mRNA levels.

1996 • 126 citations

Three-Dimensional Organization of the Recurrent Axon Collateral Network of the Substantia Nigra Pars Reticulata Neurons in the Rat

2003 • 124 citations

Neuroadaptive changes in the mesoaccumbens dopamine system after chronic nicotine self-administration: A microdialysis study

2004 • 111 citations

Differential effects of acute and chronic nicotine on dopamine output in the core and shell of the rat nucleus accumbens

1997 • 109 citations

Ethanol Suppression of Ventral Tegmental Area GABA Neuron Electrical Transmission Involves N-Methyl-d-aspartate Receptors

2004 • 103 citations

Identification of Sequence Motifs That Target Neuronal Nicotinic Receptors to Dendrites and Axons

2006 • 94 citations

Novel Seizure Phenotype and Sleep Disruptions in Knock-In Mice with Hypersensitive α4^*Nicotinic Receptors

2005 • 94 citations

A comparison of the effects of nicotine on dopamine and non-dopamine neurons in the rat ventral tegmental area: an in vitro electrophysiological study

2000 • 85 citations

Mouse strain‐specific nicotinic acetylcholine receptor expression by inhibitory interneurons and astrocytes in the dorsal hippocampus

2003 • 85 citations

Binding and functional activity of nicotinic cholinergic receptors in selected rat brain regions are increased following long‐term but not short‐term nicotine treatment

2004 • 84 citations

Subsets of acetylcholine-stimulated 86Rb+ efflux and [125I]-epibatidine binding sites in C57BL/6 mouse brain are differentially affected by chronic nicotine treatment

2004 • 83 citations

Chronic nicotine working and reference memory effects in the 16-arm radial maze: interactions with D1 agonist and antagonist drugs

1996 • 83 citations

An Extracellular Protein Microdomain Controls Up-regulation of Neuronal Nicotinic Acetylcholine Receptors by Nicotine

2004 • 79 citations

Exocytic Trafficking Is Required for Nicotine-induced Up-regulation of α4β2 Nicotinic Acetylcholine Receptors

2005 • 76 citations

Adjacent Basic Amino Acid Residues Recognized by the COP I Complex and Ubiquitination Govern Endoplasmic Reticulum to Cell Surface Trafficking of the Nicotinic Acetylcholine Receptor α-Subunit

2001 • 75 citations

Deletion of the beta 2 nicotinic acetylcholine receptor subunit alters development of tolerance to nicotine and eliminates receptor upregulation

2005 • 70 citations

β3 Subunits Promote Expression and Nicotine-Induced Up-Regulation of Human Nicotinic α6^* Nicotinic Acetylcholine Receptors Expressed in Transfected Cell Lines

2006 • 70 citations

Proteomic analysis of nicotine-associated protein expression in the striatum of repeated nicotine-treated rats

2004 • 69 citations

Facilitation of memory by post-trial administration of nicotine: evidence for an attentional explanation

1992 • 68 citations

Pharmacological comparison of transient and persistent [3H]dopamine release from mouse striatal synaptosomes and response to chronic L-nicotine treatment.

1997 • 63 citations

Family-based case-control study of cigarette smoking and Parkinson disease

2005 • 59 citations

Acute and chronic nicotine exposure reverse age-related declines in the induction of long-term potentiation in the rat hippocampus

2001 • 57 citations

Genetic Approaches Identify Differential Roles for α₄β₂^*Nicotinic Receptors in Acute Models of Antinociception in Mice

2007 • 57 citations

Effects of chronic nicotine administration and its withdrawal on striatal FosB/ΔFosB and c-Fos expression in rats and mice

2006 • 56 citations

The Neuroprotective Effect of 2-(3-Pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a Novel α7 Ligand, Is Prevented through Angiotensin II Activation of a Tyrosine Phosphatase

2004 • 55 citations

Nicotine induces long-lasting potentiation in the dentate gyrus of nicotine-primed rats

1997 • 52 citations

Immunolabeling demonstrates the interdependence of mouse brain α4 and β2 nicotinic acetylcholine receptor subunit expression

2006 • 50 citations

Nicotinic Receptor Subtypes in Rat Hippocampal Slices Are Differentially Sensitive to Desensitization and Early in Vivo Functional Up-Regulation by Nicotine and to Block by Bupropion

2005 • 50 citations

Nicotine withdrawal increases body weight, neuropeptide Y and Agouti-related protein expression in the hypothalamus and decreases uncoupling protein-3 expression in the brown adipose tissue in high-fat fed mice

2006 • 46 citations

Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines

2005 • 43 citations

Cell autonomy, receptor autonomy, and thermodynamics in nicotine receptor up-regulation

2007 • 41 citations

Effects of post-trial administration of nicotine on human memory: evaluating the conditions for improving memory

1995 • 38 citations

Nicotine withdrawal suppresses nicotinic modulation of long‐term potentiation induction in the hippocampal CA1 region

2006 • 30 citations

Blockade of nicotinic acetylcholine receptors suppresses hippocampal long‐term potentiation in wild‐type but not ApoE4 targeted replacement mice

2005 • 25 citations

Long‐lasting nicotinic modulation of GABAergic synaptic transmission in the rat nucleus accumbens associated with behavioural sensitization to amphetamine

2004 • 23 citations

Chronic nicotine‐induced switch in Src‐family kinase signaling for long‐term potentiation induction in hippocampal CA1 pyramidal cells

2006 • 17 citations

Chronic nicotine treatment increases GABAergic input to striatal neurons

2006 • 14 citations

Chronic nicotine exposure affects the normal operation of hippocampal circuits

2007 • 6 citations

FRET Measurements Using Multispectral Imaging

2005 • 3 citations