Angiotensin II-induced phosphatidylcholine hydrolysis in cultured vascular smooth-muscle cells. Regulation and localization

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Lipid Asymmetry in Membranes

1979 • 1,245 citations

Hypertension: Pathophysiology, Diagnosis, and Management

1991 • 940 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.

1989 • 508 citations

Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells.

1986 • 491 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger.

1986 • 415 citations

Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism

1988 • 413 citations

Is phosphatidic acid a calcium ionophore under neurohumoral control?

1980 • 331 citations

Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists.

1987 • 253 citations

Increase in cytosolic calcium and phosphoinositide metabolism induced by angiotensin II and [Arg]vasopressin in vascular smooth muscle cells.

1985 • 252 citations

Regulation of Phospholipase D in HL-60 Granulocytes

1989 • 250 citations

Angiotensin increases inositol trisphosphate and calcium in vascular smooth muscle.

1985 • 241 citations

Phorbol ester and 1-oleoyl-2-acetylglycerol inhibit angiotensin activation of phospholipase C in cultured vascular smooth muscle cells.

1985 • 240 citations

Mechanisms of action of calcium‐mobilizing agonists: some variations on a young theme

1988 • 236 citations

Endothelin stimulates diacylglycerol accumulation and activates protein kinase C in cultured vascular smooth muscle cells

1989 • 230 citations

Phosphatidylcholine Metabolism

2020 • 210 citations

Analysis of the water-soluble products of phosphatidylcholine breakdown by ion-exchange chromatography. Bombesin and TPA (12-O-tetradecanoylphorbol 13-acetate) stimulate choline generation in Swiss 3T3 cells by a common mechanism

1989 • 188 citations

P2-Purinergic Agonists Stimulate Phosphodiesteratic Cleavage of Phosphatidylcholine in Endothelial Cells

1989 • 180 citations

Regulation of phospholipid metabolism in differentiating cells from rat brain cerebral hemispheres in culture. Patterns of acetylcholine phosphocholine, and choline phosphoglycerides labeling from (methyl-14C)choline.

1976 • 164 citations

Correlation of receptor sequestration with sustained diacylglycerol accumulation in angiotensin II-stimulated cultured vascular smooth muscle cells.

1987 • 161 citations

Angiotensin II rapidly increases phosphatidate-phosphoinositide synthesis and phosphoinositide hydrolysis and mobilizes intracellular calcium in cultured arterial muscle cells.

1984 • 159 citations

The phosphatidylcholine pathway of diacylglycerol formation stimulated by phorbol diesters occurs via phospholipase D activation

1988 • 156 citations

Muscarinic Receptor Activation of Phosphatidylcholine Hydrolysis

1989 • 146 citations

Stimulation of Phosphatidylcholine Hydrolysis, Diacylglycerol Release, and Arachidonic Acid Production by Oncogenic Ras Is a Consequence of Protein Kinase C Activation

1989 • 136 citations

Human platelets contain phospholipase C that hydrolyzes polyphosphoinositides.

1983 • 129 citations

Multiple Sources of 1,2-Diacylglycerol in Isolated Rat Pancreatic Acini Stimulated by Cholecystokinin

1989 • 120 citations

Vasopressin induces V1 receptors to activate phosphatidylinositol- and phosphatidylcholine-specific phospholipase C and stimulates the release of arachidonic acid by at least two pathways in the smooth muscle cell line, A-10.

1988 • 117 citations

Alpha 1-adrenergic receptors promote phosphatidylcholine hydrolysis in MDCK-D1 cells. A mechanism for rapid activation of protein kinase C.

1988 • 115 citations

Hormonal stimulation of diacylglycerol formation in hepatocytes.

1989 • 111 citations

A tumour promoter, 12-O-tetradecanoylphorbol 13-acetate, increases cellular 1,2-diacylglycerol content through a mechanism other than phosphoinositide hydrolysis in Swiss-mouse 3T3 fibroblasts

1987 • 93 citations

Endogenous and exogenous domain markers of the rat hepatocyte plasma membrane.

1985 • 92 citations

Selective post-transcriptional down-regulation of protein kinase C isoenzymes in leukemic T cells chronically treated with phorbol ester.

1990 • 89 citations

Stimulation of phosphatidylinositol 4,5-bisphosphate phospholipase C activity by phosphatidic acid

1989 • 88 citations

Second messenger function of phosphatidic acid in platelet activation

1989 • 86 citations

Differential activation of protein kinase C alpha is associated with arachidonate release in Madin-Darby canine kidney cells.

1990 • 85 citations

Differences in Proliferation of Primary Cultures of Vascular Smooth Muscle Cells Taken from Male and Female Rats

1980 • 74 citations

Down-regulation of protein kinase C potentiates angiotensin II-stimulated polyphosphoinositide hydrolysis in vascular smooth-muscle cells

1989 • 69 citations

Phospholipase D activation by the mitogens platelet‐derived growth factor and 12‐O‐tetradecanoylphorbol 13‐acetate in NIH‐3T3 cells

1989 • 64 citations

Retention of specific protein kinase C isozymes following chronic phorbol ester treatment in BC3H-1 myocytes

1989 • 57 citations

Evidence that phosphatidic acid stimulates the uptake of calcium by liver cells but not calcium release from mitochondria

1981 • 52 citations

Phorbol ester effects on α1-adrenoceptor binding and phosphatidylinositol metabolism in cultured vascular smooth muscle cells

1985 • 49 citations

Distinct functions of down‐regulation‐sensitive and ‐resistant types of protein kinase C in rabbit aortic smooth muscle cells

1987 • 47 citations

Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by muscarinic agonists

1989 • 46 citations

Mechanism of cellular effect of phorbol esters on action of arginine vasopressin and angiotensin II on rat vascular smooth muscle cells in culture

1988 • 40 citations

Transmembrane calcium movements mediated by ionomycin and phosphatidate in liposomes with Fura 2 entrapped

1988 • 36 citations

Evidence that Na+/H+ exchange regulates angiotensin II-stimulated diacylglycerol accumulation in vascular smooth muscle cells.

1988 • 35 citations

Adenine nucleotides modulate phosphatidylcholine metabolism in aortic endothelial cells

1990 • 35 citations

Angiotensin II stimulates vimentin phosphorylation via a Ca2+-dependent, protein kinase C-independent mechanism in cultured vascular smooth muscle cells.

1988 • 26 citations

Effects of Phosphatidic Acid on Parathyroid Hormone Release, Intracellular Free Ca²⁺, and Inositol Phosphates in Dispersed Bovine Parathyroid Cells*

1990 • 20 citations

Isozymic forms of protein kinase C in regenerating rat liver

1989 • 19 citations

Potassium depletion selectively inhibits sustained diacylglycerol formation from phosphatidylinositol in angiotensin II-stimulated, cultured vascular smooth muscle cells.

1987 • 18 citations

A mechanism for phosphoglyceride and Ca2+ transbilayer movement

1985 • 18 citations

Electron microscopic observation of domain movement in reconstituted erythrocyte membranes.

1985 • 15 citations

Lipid domain structures in biological membranes

1983 • 8 citations