Phospholipases C and D in mitogenic signal transduction

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

1989 • 1,405 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Two G Protein Oncogenes in Human Endocrine Tumors

1990 • 1,038 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G _q

1991 • 886 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin

1985 • 824 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1991 • 774 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONS

1989 • 739 citations

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

1987 • 670 citations

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1990 • 650 citations

Purification and characterization of phosphoinositide 3-kinase from rat liver.

1990 • 640 citations

Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation

1991 • 532 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction

1989 • 516 citations

Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

1988 • 492 citations

Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells.

1986 • 491 citations

Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

1991 • 488 citations

A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts

1989 • 485 citations

PDGF induction of tyrosine phosphorylation of GTPase activating protein

1989 • 478 citations

The Actin-Binding Protein Profilin Binds to PIP ₂ and Inhibits Its Hydrolysis by Phospholipase C

1990 • 472 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.

1990 • 463 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger.

1986 • 415 citations

Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3.

1991 • 415 citations

A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family

1988 • 414 citations

Polyphosphoinositide phosphodiesterase: regulation by a novel guanine nucleotide binding protein, Gp

1987 • 356 citations

Phosphatidylethanol Formation via Transphosphatidylation by Rat Brain Synaptosomal Phospholipase D

1987 • 342 citations

Is phosphatidic acid a calcium ionophore under neurohumoral control?

1980 • 331 citations

Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells.

1991 • 330 citations

Inositol lipids and cell proliferation

1987 • 315 citations

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

1987 • 303 citations

Protein kinase C — a family affair

1989 • 289 citations

The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

1989 • 287 citations

Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA

1988 • 285 citations

Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells.

1990 • 282 citations

Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action.

1990 • 264 citations

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity.

1990 • 264 citations

Polyphosphoinositides Produced by Phosphatidylinositol 3-Kinase Are Poor Substrates for Phospholipases C from Rat Liver and Bovine Brain

1989 • 238 citations

Choline-linked Phosphoglycerides

1989 • 234 citations

Expression, purification, and characterization of protein kinase C-epsilon.

1990 • 231 citations

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

1987 • 219 citations

Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart.

1991 • 212 citations

Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts. Comparison of stimulation by alpha-thrombin and epidermal growth factor.

1988 • 207 citations

Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil

1989 • 204 citations

Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain.

1990 • 191 citations

The PtdIns-PLC superfamily and signal transduction

1991 • 190 citations

Analysis of the water-soluble products of phosphatidylcholine breakdown by ion-exchange chromatography. Bombesin and TPA (12-O-tetradecanoylphorbol 13-acetate) stimulate choline generation in Swiss 3T3 cells by a common mechanism

1989 • 188 citations

P2-Purinergic Agonists Stimulate Phosphodiesteratic Cleavage of Phosphatidylcholine in Endothelial Cells

1989 • 180 citations

Tyrphostins—Potential antiproliferative agents and novel molecular tools

1990 • 177 citations

The effects of bombesin on polyphosphoinositide and calcium metabolism in Swiss 3T3 cells.

1987 • 175 citations

Identification of three additional members of rat protein kinase C family: gd‐, ϵ‐ and ξ‐subspecies

1987 • 173 citations

Purification of unique alpha subunits of GTP-binding regulatory proteins (G proteins) by affinity chromatography with immobilized beta gamma subunits.

1990 • 169 citations

Gonadotropin-releasing hormone activates phospholipase D in ovarian granulosa cells

1989 • 168 citations

Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.

1990 • 167 citations

Protein kinase C mediates platelet-derived growth factor-induced tyrosine phosphorylation of p42.

1988 • 166 citations

Phosphoinositide metabolism and the control of cell proliferation

1989 • 165 citations

Phospholipase C-mediated hydrolysis of phosphatidlycholine is an important step in PDGF-stimulated DNA synthesis

1990 • 163 citations

Molecular Species Analysis of 1,2-Diglycerides Stimulated by α-Thrombin in Cultured Fibroblasts

1989 • 161 citations

Lack of association of epidermal growth factor-, insulin-, and serum-induced mitogenesis with stimulation of phosphoinositide degradation in BALB/c 3T3 fibroblasts.

1986 • 156 citations

Different effects of platelet-derived growth factor isoforms on rat vascular smooth muscle cells.

1990 • 155 citations

A Cytoplasmic Protein Inhibits the GTPase Activity of H-Ras in a Phospholipid-Dependent Manner

1990 • 153 citations

Ca2+-dependent conversion of phosphatidylinositol to phosphatidate in neutrophils stimulated with fMet-Leu-Phe or ionophore A23187

1984 • 152 citations

Phosphorylation of an acidic mol. wt. 80 000 cellular protein in a cell-free system and intact Swiss 3T3 cells: a specific marker of protein kinase C activity.

1986 • 147 citations

Mitogenesis in Response to PDGF and Bombesin Abolished by Microinjection of Antibody to PIP ₂

1988 • 146 citations

Muscarinic Receptor Activation of Phosphatidylcholine Hydrolysis

1989 • 146 citations

Ca2+-channel blockers inhibit the action of recombinant platelet-derived growth factor in vascular smooth muscle cells.

1989 • 138 citations

Phosphatidylinositol 3-Phosphate Is Present in Normal and Transformed Fibroblasts and Is Resistant to Hydrolysis by Bovine Brain Phospholipase C II

1989 • 137 citations

Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor

1990 • 136 citations

A membrane-bound diacylglycerol kinase that selectively phosphorylates arachidonoyl-diacylglycerol. Distinction from cytosolic diacylglycerol kinase and comparison with the membrane-bound enzyme from Escherichia coli.

1988 • 134 citations

Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide.

1986 • 132 citations

Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: Evidence for a role of protein kinase C

1987 • 127 citations

Ca2+-mobilizing actions of platelet-derived growth factor differ from those of bombesin and vasopressin in Swiss 3T3 mouse cells.

1987 • 126 citations

Dissociation of protein kinase C activation and sn-1,2-diacylglycerol formation. Comparison of phosphatidylinositol- and phosphatidylcholine-derived diglycerides in alpha-thrombin-stimulated fibroblasts.

1991 • 120 citations

Protein kinase C-mediated negative-feedback inhibition of unstimulated and bombesin-stimulated polyphosphoinositide hydrolysis in Swiss-mouse 3T3 cells

1987 • 114 citations

Phorbol diesters stimulate the accumulation of phosphatidate, phosphatidylethanol, and diacylglycerol in three cell types. Evidence for the indirect formation of phosphatidylcholine-derived diacylglycerol by a phospholipase D pathway and direct formation of diacylglycerol by a phospholipase C pathway.

1990 • 113 citations

Molecular species analysis of mitogen-stimulated 1,2-diglycerides in fibroblasts. Comparison of alpha-thrombin, epidermal growth factor, and platelet-derived growth factor.

1990 • 110 citations

Elevated phosphocholine concentration in ras-transformed NIH 3T3 cells arises from increased choline kinase activity, not from phosphatidylcholine breakdown.

1989 • 106 citations

Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: <scp>d</scp>-phosphatidyl-myo-inositol 3-phosphate

1989 • 104 citations

Multiple sources of sn-1,2-diacylglycerol in platelet-derived-growth-factor-stimulated Swiss 3T3 fibroblasts. Evidence for activation of phosphoinositidase C and phosphatidylcholine-specific phospholipase D

1991 • 97 citations

Phospholipase D in homogenates from HL-60 granulocytes: Implications of calcium and G protein control

1989 • 91 citations

Phosphatidylinositol 4,5-bisphosphate turnover is transient while phosphatidylinositol turnover is persistent in thyrotropin-releasing hormone-stimulated rat pituitary cells.

1986 • 90 citations

Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not Go to S phase progression in hamster fibroblasts. Comparison of thrombin and carbachol action in cells expressing M1 muscarinic acetylcholine receptors.

1990 • 89 citations

Epidermal growth factor increases sn-1,2-diacylglycerol levels and activates phospholipase D-catalysed phosphatidylcholine breakdown in Swiss 3T3 cells in the absence of inositol-lipid hydrolysis

1992 • 88 citations

Colony-stimulating factor 1 activates protein kinase C in human monocytes.

1990 • 87 citations

Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins.

1992 • 84 citations

Sustained increase in 1,2-diacylglycerol precedes DNA synthesis in epidermal-growth-factor-stimulated fibroblasts. Evidence for stimulated phosphatidylcholine hydrolysis

1990 • 73 citations

Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gsα

1990 • 70 citations

Stimulation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine by endothelin, a complete mitogen for Rat-1 fibroblasts

1990 • 68 citations

Mass measurement of inositol 1,4,5-trisphosphate and sn-1,2-diacylglycerol in bombesin-stimulated Swiss 3T3 mouse fibroblasts

1990 • 67 citations

Ca2+ and pH responses to sequential additions of mitogens in single 3T3 fibroblasts: correlations with DNA synthesis.

1988 • 67 citations

Inositol 1,3,4,5-tetrakisphosphate-induced release of intracellular Ca2+ in SH-SY5Y neuroblastoma cells

1990 • 65 citations

Phospholipase D activation by the mitogens platelet‐derived growth factor and 12‐O‐tetradecanoylphorbol 13‐acetate in NIH‐3T3 cells

1989 • 64 citations

The regulation of phospholipase D activity and its role in sn-1,2-diradylglycerol formation in bombesin- and phorbol 12-myristate 13-acetate-stimulated Swiss 3T3 cells

1991 • 62 citations

Granulocyte phospholipase D is activated by a guanine nucleotide dependent protein factor

1991 • 62 citations

Diacylglycerol stimulates phospholipase A₂ from Swiss 3T3 fibroblasts

1988 • 57 citations

Ca2+-independent activation of protease-activated kinase II by phospholipids/diolein and comparison with the Ca2+/phospholipid-dependent protein kinase.

1986 • 56 citations

Stimulation of phosphatidylcholine breakdown and diacylglycerol production by growth factors in Swiss-3T3 cells

1989 • 56 citations

Role of Ca2+ influx in bombesin-induced mitogenesis in Swiss 3T3 fibroblasts

1991 • 55 citations

Effects of pertussis toxin on growth factor-stimulated inositol phosphate formation and DNA synthesis in Swiss 3T3 cells

1988 • 53 citations

Quantitative Changes in Polyphosphoinositides 1,2-Diacylglycerol and Inositol 1,4,5-Trisphosphate by Platelet-derived Growth Factor and Prostaglandin F2α

1989 • 52 citations

Vasopressin-induced polyphosphoinositide and phosphatidylcholine degradation in fibroblasts. Temporal relationship for formation of phospholipase C and phospholipase D hydrolysis products.

1990 • 51 citations

Hydrolysis of phosphatidylcholine by phospholipase D is a common response to mitogens which stimulate inositol lipid hydrolysis in Swiss 3T3 fibroblasts

1991 • 51 citations

Differences in the regulation of endothelin-1- and lysophosphatidic-acid-stimulated Ins(1,4,5)P3 formation in rat-1 fibroblasts

1991 • 48 citations

Fibroblast growth factor stimulates protein kinase C in quiescent 3T3 cells without Ca²⁺ mobilization or inositol phosphate accumulation

1990 • 48 citations

Regulation of bombesin-stimulated inositol 1,4,5-trisphosphate generation in Swiss 3T3 fibroblasts by a guanine-nucleotide-binding protein

1990 • 39 citations

Evidence for the calcium-dependent activation of phospholipase D in thrombin-stimulated human erythroleukaemia cells

1990 • 36 citations

Stimulation of polyphosphoinositide hydrolysis in Swiss 3T3 cells by recombinant fibroblast growth factors

1989 • 35 citations

Inhibition of the metabolism of phosphatidylethanol and phosphatidic acid, and stimulation of insulin release, by propranolol in intact pancreatic islets

1991 • 33 citations

Differential mechanisms of inositol phosphate generation at the receptors for bombesin and platelet-derived growth factor

1989 • 32 citations

Counter-regulatory effects of phosphatidic acid on protein kinase C activity in the presence of calcium and diolein

1990 • 29 citations

Phosphatidylcholine hydrolysis stimulated by phorbol myristate acetate is mediated principally by phospholipase D in endothelial cells

1990 • 28 citations

cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.

1990 • 26 citations

Chapter 3 Myoblast Fusion–A Mechanistic Analysis

1988 • 25 citations

Diacylglycerol, but not inositol 1,4,5‐trisphosphate, accounts for platelet‐derived growth factor‐stimulated proliferation of BALB 3T3 cells

1989 • 22 citations

Embryonal carcinoma-derived growth factor activates protein kinase C in vivo and in vitro.

1987 • 22 citations

Epidermal growth factor and bombesin differ strikingly in the induction of early responses in Swiss 3T3 cells

1990 • 20 citations

Regulation of the hydrolysis of phosphatidylcholine in Swiss 3T3 cells

1991 • 16 citations

G Proteins in Growth Factor Action

1990 • 13 citations

GTP-binding protein-stimulated phospholipase C and phospholipase D activities in ras-transformed NIH 3T3 fibroblasts.

1990 • 9 citations

The role of ras gene products in second messenger generation.

1990 • 3 citations