Thrombospondin as a mediator of cancer cell adhesion in metastasis

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

The platelet membrane glycoprotein IIb-IIIa complex

1988 • 1,031 citations

The platelet membrane glycoprotein IIb-IIIa complex

1988 • 841 citations

The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.

1986 • 575 citations

Isolation of the thrombospondin membrane receptor.

1987 • 518 citations

Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors.

1988 • 481 citations

Isolation and characterization of a high molecular weight glycoprotein from human blood platelets.

1978 • 428 citations

Characterization of fibronectin interactions with glycosaminoglycans and identification of active proteolytic fragments.

1980 • 410 citations

Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor.

1990 • 407 citations

A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite

1988 • 386 citations

The structural and functional properties of thrombospondin

1986 • 333 citations

A Thrombin-Sensitive Protein of Human Platelet Membranes

1971 • 333 citations

Synthesis and secretion of thrombospondin by cultured human endothelial cells.

1982 • 311 citations

Isolation and Properties of a Thrombin-sensitive Protein of Human Platelets

1972 • 306 citations

Effects of LETS glycoprotein on cell motility

1978 • 277 citations

Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro.

1991 • 273 citations

Thrombospondin modulates focal adhesions in endothelial cells.

1989 • 271 citations

Cultured human fibroblasts synthesize and secrete thrombospondin and incorporate it into extracellular matrix.

1983 • 266 citations

Light microscopic immunolocation of thrombospondin in human tissues.

1985 • 265 citations

The structural and functional properties of thrombospondin

1986 • 261 citations

Control of smooth muscle cell growth by components of the extracellular matrix: autocrine role for thrombospondin.

1986 • 259 citations

Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation

1988 • 256 citations

Role of thrombospondin in platelet aggregation.

1984 • 247 citations

Vitronectin and thrombospondin promote retinal neurite outgrowth: Developmental regulation and role of integrins

1991 • 237 citations

Platelet-derived growth factor and heparin-like glycosaminoglycans regulate thrombospondin synthesis and deposition in the matrix by smooth muscle cells.

1985 • 232 citations

Heparan sulfate-mediated binding of epithelial cell surface proteoglycan to thrombospondin

1989 • 222 citations

The structure of human platelet thrombospondin.

1985 • 222 citations

Isolation and characterization of a glycoprotein secreted by aortic endothelial cells in culture. Apparent identity with platelet thrombospondin.

1981 • 216 citations

Monocytes and macrophages synthesize and secrete thrombospondin

1985 • 208 citations

Thrombospondin-induced tumor cell migration: haptotaxis and chemotaxis are mediated by different molecular domains.

1987 • 206 citations

Thrombospondin: a modular adhesive glycoprotein of platelets and nucleated cells.

1987 • 205 citations

Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding

1992 • 205 citations

Differential expression of extracellular proteins is correlated with angiogenesis in vitro.

1991 • 199 citations

Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion.

1989 • 198 citations

Platelet thrombospondin mediates attachment and spreading of human melanoma cells.

1987 • 196 citations

Complex formation of platelet thrombospondin with fibrinogen.

1982 • 195 citations

Physiology of Thrombospondin

1990 • 195 citations

The platelet glycoprotein thrombospondin binds specifically to sulfated glycolipids.

1985 • 191 citations

Thrombospondin is the endogenous lectin of human platelets

1982 • 183 citations

Isolation and characterization of a heparin-binding domain from the amino terminus of platelet thrombospondin.

1984 • 181 citations

The structure and stability of human plasma cold-insoluble globulin.

1979 • 178 citations

Thrombospondins

1991 • 169 citations

Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator.

1984 • 164 citations

Heparin- and sulfatide-binding peptides from the type I repeats of human thrombospondin promote melanoma cell adhesion.

1992 • 163 citations

Identification of a Disaccharide (Xyl-Glc) and a Trisaccharide (Xyl2-Glc) O-Glycosidically Linked to a Serine Residue in the First Epidermal Growth Factor-like Domain of Human Factors VII and IX and Protein Z and Bovine Protein Z

1989 • 161 citations

An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin [see comments]

1989 • 158 citations

Thrombospondin, a potentiator of tumor cell metastasis.

1987 • 156 citations

A monoclonal antibody against human thrombospondin inhibits platelet aggregation.

1985 • 152 citations

Complex formation of platelet thrombospondin with histidine-rich glycoprotein.

1984 • 151 citations

Transforming growth factor (type beta) promotes the addition of chondroitin sulfate chains to the cell surface proteoglycan (syndecan) of mouse mammary epithelia.

1989 • 138 citations

Interactions of thrombospondin with endothelial cells: receptor-mediated binding and degradation.

1987 • 135 citations

Thrombospondin is an osteoblast-derived component of mineralized extracellular matrix.

1989 • 130 citations

Functional domain structure of fibronectin.

1980 • 130 citations

Granular pneumocytes in primary culture secrete several major components of the extracellular matrix

1983 • 126 citations

Thrombospondin-induced attachment and spreading of human squamous carcinoma cells

1986 • 124 citations

A second, expressed thrombospondin gene (Thbs2) exists in the mouse genome

1991 • 120 citations

An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin [see comments]

1989 • 119 citations

Incorporation of thrombospondin into fibrin clots.

1985 • 118 citations

Biochemistry of alpha granule proteins.

1985 • 112 citations

Human brain glial cells synthesize thrombospondin.

1986 • 110 citations

Mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electron microscopy and high sensitivity amino acid sequencing.

1985 • 109 citations

Thrombospondin functions as a cytoadhesion molecule for human hematopoietic progenitor cells

1990 • 107 citations

Cellular attachment to thrombospondin. Cooperative interactions between receptor systems

1991 • 99 citations

Cooperative binding of calcium to thrombospondin. The effect of calcium on the circular dichroism and limited tryptic digestion of thrombospondin.

1983 • 98 citations

Topological arrangement of the major structural features of fibronectin.

1980 • 97 citations

Activation of immobilized plasminogen by tissue activator. Multimolecular complex formation.

1985 • 97 citations

The interaction of human platelet thrombospondin with fibrinogen. Thrombospondin purification and specificity of interaction.

1985 • 95 citations

Complex formation of human thrombospondin with osteonectin

1988 • 95 citations

Thrombospondin-induced adhesion of human keratinocytes.

1988 • 89 citations

Biological activities of peptides and peptide analogues derived from common sequences present in thrombospondin, properdin, and malarial proteins.

1992 • 87 citations

Thrombospondin stimulates motility of human neutrophils.

1990 • 87 citations

Chinese hamster ovary cell adhesion to human platelet thrombospondin is dependent on cell surface heparan sulfate proteoglycan.

1989 • 80 citations

Localization of two unique heparin binding domains of human plasma fibronectin with monoclonal antibodies.

1982 • 77 citations

Location of a gelatin-binding region of human plasma fibronectin.

1980 • 74 citations

Isolation and characterization of a heparin-binding domain of cellular fibronectin.

1980 • 74 citations

Effects of thrombospondin on fibrin polymerization and structure.

1986 • 73 citations

Interaction of thrombospondin with resting and stimulated human platelets.

1986 • 72 citations

Complete thrombospondin mRNA sequence includes potential regulatory sites in the 3' untranslated region.

1989 • 72 citations

Platelet membrane topography: colocalization of thrombospondin and fibrinogen with the glycoprotein IIb-IIIa complex

1985 • 69 citations

Interactions of thrombospondin with sulfated glycolipids and proteoglycans of human melanoma cells.

1988 • 68 citations

Thrombospondin promotes platelet aggregation

1988 • 67 citations

Free thiols of platelet thrombospondin. Evidence for disulfide isomerization.

1990 • 67 citations

Developmentally regulated expression of a 78 kDa erythroblast membrane glycoprotein immunologically related to the platelet thrombospondin receptor

1989 • 66 citations

The interaction of thrombospondin with platelet glycoprotein GPIIb-IIIa

1989 • 64 citations

Thrombospondin-induced adhesion of human platelets.

1991 • 62 citations

Expression and mutagenesis of thrombospondin

1992 • 61 citations

Thrombospondin secretion by cultured human glomerular mesangial cells.

1987 • 60 citations

Thrombospondin is a slow tight-binding inhibitor of plasmin

1992 • 59 citations

The endogenous lectin of human platelets is an alpha-granule component

1981 • 58 citations

Characterization of the mouse thrombospondin gene and evaluation of the role of the first intron in human gene expression.

1990 • 55 citations

Structure and chromosomal localization of the human thrombospondin gene

1990 • 54 citations

Characterization of the Promoter Region of the Human Thrombospondin Gene

1989 • 54 citations

Antibodies against a 23Kd heparin binding fragment of thrombospondin inhibit platelet aggregation

1984 • 53 citations

Thrombin and Chymotrypsin Interactions with Thrombospondin^a

1986 • 51 citations

Human Keratinocytes Synthesize and Secrete the Extracellular Matrix Protein, Thrombospondin

1987 • 50 citations

Thrombospondin is present in articular cartilage and is synthesized by articular chondrocytes

1988 • 48 citations

Cloning and sequencing of chicken thrombospondin

1991 • 47 citations

Thrombospondin promotes platelet aggregation

1988 • 46 citations

Localization of the hemagglutinating activity of platelet thrombospondin to a 140,000-dalton thermolytic fragment

1984 • 45 citations

Thrombospondin binding by human squamous carcinoma and melanoma cells: Relationship to biological activity

1988 • 44 citations

Suramin inhibits laminin- and thrombospondin-mediated melanoma cell adhesion and migration and binding of these adhesive proteins to sulfatide.

1990 • 42 citations

Formation of a stable complex of thrombin and the secreted platelet protein glycoprotein G (thrombin-sensitive protein, thrombospondin) by thiol-disulfide exchange

1984 • 42 citations

The GPIIb-IIIa-like complex may function as a human melanoma cell adhesion receptor for thrombospondin

1989 • 41 citations

Divalent cation-dependent and independent surface expression of thrombospondin on thrombin-stimulated human platelets

1987 • 37 citations

Characterization of thrombospondin as a substrate for factor XIII transglutaminase.

1987 • 37 citations

Evidence for the Existence of O-Linked Sugar Chains Consisting of Glucose and Xylose in Bovine Thrombospondin1

1992 • 37 citations

Mapping of the thrombospondin gene to human chromosome 15 and mouse chromosome 2 by in situ hybridization

1990 • 37 citations

Structural Organization of the Thrombospondin Molecule

1987 • 36 citations

Human carcinoma cells bind thrombospondin through a Mr 80,000/105,000 receptor.

1991 • 35 citations

Thrombospondin binding to specific sequences within the A alpha- and B beta-chains of fibrinogen.

1990 • 34 citations

Role of IIb‐IIIa‐like glycoproteins in cell‐substratum adhesion of human melanoma cells

1988 • 34 citations

Thrombospondin expression in traumatized skeletal muscle

1990 • 33 citations

Thrombospondin: phenomenology to function.

1989 • 33 citations

Multiple domains are involved in the interaction of endothelial cell thrombospondin with fibronectin

1989 • 32 citations

Thrombospondin interaction with plasminogen. Evidence for binding to a specific region of the kringle structure of plasminogen

1989 • 30 citations

Thrombospondin interaction with fibrinogen. Evidence for binding to the A alpha- and B beta-chains of fibrinogen.

1987 • 25 citations

Thrombospondin in Milk, Other Breast Secretions, and Breast Tissue

1987 • 22 citations

Characterization of the platelet agglutinating activity of thrombospondin

1985 • 22 citations

The structure of endothelial cell thrombospondin

1987 • 20 citations

Adhesive molecules in liver disease

1990 • 18 citations

Endothelial Cell Thrombospondin and Its Possible Role in Cell Adhesion

1987 • 18 citations

Thrombospondin fragmentation by α-thrombin and resistance to γ-thrombin

1984 • 17 citations

Glycoproteins IIb and IIIa and Platelet Thrombospondin in a Liposome Model of Platelet Aggregation

1986 • 16 citations

Noncovalent and Covalent Interactions of Thrombospondin with Polymerizing Fibrin

1987 • 12 citations

Thrombospondin

1987 • 12 citations

Isolation and identification of a 23,000-Dalton heparin binding fragment from the amino terminus of bovine thrombospondin

1986 • 10 citations

Localization of two binding domains for thrombospondin within fibronectin

1992 • 10 citations

Incorporation of amino acids into polyribosome-associated protein in cytoplasmic extracts of poliovirus-infected Hela cells

1964 • 9 citations

Cell attachment and fibrinogen binding properties of platelet and endothelial cell thrombospondin are not affected by structural differences in the 70 and 18 kDa protease‐resistant domains

1988 • 8 citations

Production, Characterization, and Use of Monoclonal Antibodies Directed Against Human Blood Platelet Thrombospondin: Immunologic Comparison with Human Endothelial and Fibroblast Thrombospondins

1987 • 4 citations

Deleted Work

1955 • 0 citations