Cofactor residues lysine 165 and 166 are critical for protein substrate recognition by the tissue factor-factor VIIa protease complex.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Surface-dependent reactions of the vitamin K-dependent enzyme complexes

1990 • 853 citations

A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor.

1991 • 286 citations

Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells

1988 • 270 citations

Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine

1986 • 259 citations

Initiation of Coagulation by Tissue Facto

1988 • 258 citations

Cell Surface Receptors: A Short Course on Theory and Methods

1986 • 246 citations

Activation of factor VII bound to tissue factor: a key early step in the tissue factor pathway of blood coagulation.

1988 • 232 citations

Functional tissue factor is entirely cell surface expressed on lipopolysaccharide-stimulated human blood monocytes and a constitutively tissue factor-producing neoplastic cell line.

1989 • 232 citations

Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function

1991 • 228 citations

Cooperative activation of human factor IX by the human extrinsic pathway of blood coagulation

1991 • 158 citations

The Last Three Consecutive Epidermal Growth Factor-like Structures of Human Thrombomodulin Comprise the Minimum Functional Domain for Protein C-activating Cofactor Activity and Anticoagulant Activity

1989 • 149 citations

Bacteriophage lambda cro mutations: effects on activity and intracellular degradation.

1986 • 145 citations

A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site.

1988 • 130 citations

An ordered addition, essential activation model of the tissue factor pathway of coagulation: evidence for a conformational cage

1986 • 121 citations

Characterization of factor VII association with tissue factor in solution. High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions

1991 • 109 citations

Autoactivation of human recombinant coagulation factor VII

1989 • 100 citations

Oxford surveys of eukaryotic genes

1987 • 100 citations

An anti-tissue factor monoclonal antibody which inhibits TF.VIIa complex is a potent anticoagulant in plasma.

1991 • 96 citations

The integrity of the cysteine 186-cysteine 209 bond of the second disulfide loop of tissue factor is required for binding of factor VII

1991 • 94 citations

Microthrombomodulin

1989 • 86 citations

Further localization of binding sites for thrombin and protein C in human thrombomodulin

1990 • 80 citations

Cooperative interaction between factor VII and cell surface-expressed tissue factor.

1987 • 72 citations

An Anti-Tissue Factor Monoclonal Antibody which Inhibits TF Vlla Complex Is a Potent Anticoagulant in Plasma

1991 • 67 citations

The gamma-carboxyglutamic acid domain of human factor VIIa is essential for its interaction with cell surface tissue factor.

1990 • 64 citations

Resolution of monomeric and heterodimeric forms of tissue factor, the high-affinity cellular receptor for factor VII

1988 • 51 citations

Antibody mapping of tissue factor implicates two different exon-encoded regions in function

1991 • 49 citations

The importance of residues 195-206 of human blood clotting factor VII in the interaction of factor VII with tissue factor.

1990 • 49 citations

Self-association of tissue factor as revealed by chemical crosslinking.

1991 • 43 citations

Two sites in the tissue factor extracellular domain mediate the recognition of the ligand factor VIIa.

1991 • 42 citations

Identification of molecular sites on factor VII which mediate its assembly and function in the extrinsic pathway activation complex.

1991 • 39 citations