Possible Participation of Autocrine and Paracrine Vascular Endothelial Growth Factors in Hypoxia-induced Proliferation of Endothelial Cells and Pericytes

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Angiogenic Factors

1987 • 3,702 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Angiogenesis.

1992 • 2,581 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

Quantitation of mRNA by the polymerase chain reaction.

1989 • 1,648 citations

Epidermal growth factor.

1990 • 1,645 citations

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1992 • 1,528 citations

The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA

1991 • 1,375 citations

Structural Characterization and Biological Functions of Fibroblast Growth Factor

1987 • 1,299 citations

Tissue Culture. Methods and Applications

1974 • 1,068 citations

Angiogenesis in vitro

1980 • 1,041 citations

Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth

1987 • 764 citations

Hypoxia induces endothelin gene expression and secretion in cultured human endothelium.

1991 • 691 citations

The vascular endothelial growth factor family of polypeptides

1991 • 652 citations

Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis.

1988 • 647 citations

Large induction of keratinocyte growth factor expression in the dermis during wound healing.

1992 • 603 citations

Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells.

1989 • 568 citations

Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor.

1990 • 503 citations

A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF.

1995 • 480 citations

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.

1990 • 449 citations

Transforming growth factor-alpha. A model for membrane-anchored growth factors.

1990 • 430 citations

Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells.

1990 • 390 citations

TGF-β inhibition of endothelial cell proliferation: Alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression

1987 • 344 citations

Structural and functional studies on platelet-derived growth factor.

1992 • 335 citations

Purification and properties of an endothelial cell growth factor from human platelets.

1987 • 330 citations

Vascular aldosterone. Biosynthesis and a link to angiotensin II-induced hypertrophy of vascular smooth muscle cells.

1994 • 314 citations

The Vascular Endothelial Growth Factor Proteins: Identification of Biologically Relevant Regions by Neutralizing Monoclonal Antibodies

1992 • 309 citations

Hypoxia Is a Strong Inducer of Vascular Endothelial Growth Factor mRNA Expression in the Heart

1993 • 308 citations

The Pericyte as a Possible Osteoblast Progenitor Cell

1992 • 295 citations

FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines.

1992 • 285 citations

Vasculotropin/Vascular Endothelial Growth Factor Induces Differentiation in Cultured Osteoblasts

1994 • 285 citations

Vascular Endothelial Growth Factor is Expressed in Rat Corpus Luteum

1990 • 284 citations

Purification of a glycoprotein vascular endothelial cell mitogen from a rat glioma-derived cell line.

1990 • 230 citations

Selective elimination of mRNAs in vivo: complementary oligodeoxynucleotides promote RNA degradation by an RNase H-like activity.

1987 • 225 citations

Human mesangial cells and peripheral blood mononuclear cells produce vascular permeability factor

1993 • 165 citations

AIDS-associated kaposi's sarcoma cells in culture express vascular endothelial growth factor

1992 • 164 citations

Transcriptional Regulation of Vascular Endothelial Growth Factor Gene Expression in Ovarian Bovine Granulosa Cells

1993 • 156 citations

Aortic Smooth Muscle Cells Express and Secrete Vascular Endothelial Growth Factor

1991 • 148 citations

Translation arrest by oligodeoxynucleotides complementary to mRNA coding sequences yields polypeptides of predetermined length

1986 • 142 citations

High and low affinity binding of heparin-binding growth factor to a 130-kDa receptor correlates with stimulation and inhibition of growth of a differentiated human hepatoma cell.

1988 • 126 citations

Expression of Vascular Endothelial Growth Factor in Capillary Hemangioblastoma

1993 • 86 citations

Expression of platelet-derived growth factor beta-receptors on stromal tissue cells in human carcinoid tumors.

1990 • 79 citations

Expression of Vascular Endothelial Growth Factor by Cultured Endothelial Cells from Brain Microvessels

1993 • 73 citations

Vascular Pericytes Not Only Regulate Growth, but Also Preserve Prostacyclin-Producing Ability and Protect Against Lipid Peroxide-Induced Injury of Cocultured Endothelial Cells

1993 • 71 citations

An Endothelial Cell Growth Factor from the Mouse Neuroblastoma Cell Line NB41

1989 • 71 citations

Endothelin-1 Mediates Endothelial Cell-Dependent Proliferation of Vascular Pericytes

1993 • 67 citations

Quantitative RT-PCR Assay Detecting the Transcriptional Induction of Vascular Endothelial Growth Factor Under Hypoxia

1994 • 33 citations

Long-term serial cultivation and growth requirements for human umbilical vein endothelial cells

1985 • 27 citations

Angiotensin II up-regulates the expression of type A endothelin receptor in human vascular smooth muscle cells.

1994 • 20 citations

Specific detection of c-erbB-2 mRNA expression in gastric cancers by the polymerase chain reaction following reverse transcription

1992 • 14 citations