Structural Basis of Smad1 Activation by Receptor Kinase Phosphorylation

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

2000 • 1,299 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1998 • 714 citations

Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA

1998 • 696 citations

Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer

1998 • 562 citations

Smads as transcriptional co-modulators

2000 • 522 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling

1997 • 470 citations

A structural basis for mutational inactivation of the tumour suppressor Smad4

1997 • 459 citations

The Molecular Basis of FHA Domain:Phosphopeptide Binding Specificity and Implications for Phospho-Dependent Signaling Mechanisms

2000 • 449 citations

Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF-β

2000 • 392 citations

The L45 loop in type I receptors for TGF‐β family members is a critical determinant in specifying Smad isoform activation

1998 • 390 citations

Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling

1997 • 383 citations

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

1997 • 365 citations

Determinants of specificity in TGF-β signal transduction

1998 • 364 citations

The TGFβ Receptor Activation Process

2001 • 360 citations

Structural Basis of Smad2 Recognition by the Smad Anchor for Receptor Activation

2000 • 291 citations

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

1998 • 281 citations

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors

1998 • 265 citations

Heteromeric and Homomeric Interactions Correlate with Signaling Activity and Functional Cooperativity of Smad3 and Smad4/DPC4

1997 • 207 citations

A kinase subdomain of transforming growth factor-β (TGF-β) type I receptor determines the TGF-β intracellular signaling specificity

1997 • 203 citations

Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads

2001 • 198 citations

TGF-β singaling and cancer: structural and functional consequences of mutations in Smads

1998 • 160 citations

Characterization of Functional Domains within Smad4/DPC4

1997 • 151 citations

The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization.

2001 • 141 citations

TGF-β signaling from receptors to the nucleus

1999 • 141 citations

Structure and function of a new phosphopeptide-binding domain containing the FHA2 of rad53

1999 • 114 citations

Formation of a Stable Heterodimer between Smad2 and Smad4

2001 • 85 citations

Crystal structure of a transcriptionally active Smad4 fragment

1999 • 64 citations

Analysis of weight average sedimentation velocity data

2000 • 58 citations

Sedimentation Studies Reveal a Direct Role of Phosphorylation in Smad3:Smad4 Homo- and Hetero-Trimerization

2001 • 56 citations