Modulation of costimulation to enhance tumor immunity

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

2016 • 29,943 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1999 • 1,418 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

1999 • 1,000 citations

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

2003 • 981 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production

2003 • 933 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

B7-H3: A costimulatory molecule for T cell activation and IFN-γ production

2001 • 916 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

2002 • 908 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

The B7 Family of Ligands and Its Receptors: New Pathways for Costimulation and Inhibition of Immune Responses

2002 • 884 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

T-cell co-stimulation through B7RP-1 and ICOS

1999 • 758 citations

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

1990 • 745 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses

1998 • 515 citations

Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity.

1994 • 482 citations

PD-1: an inhibitory immunoreceptor involved in peripheral tolerance

2001 • 467 citations

CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

1999 • 463 citations

B7h, a Novel Costimulatory Homolog of B7.1 and B7.2, Is Induced by TNFα

1999 • 440 citations

Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells

2000 • 423 citations

Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.

2000 • 421 citations

Expression and function of OX40 ligand on human dendritic cells.

1997 • 416 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

Engagement of the OX-40 Receptor In Vivo Enhances Antitumor Immunity

2000 • 386 citations

Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer

1997 • 383 citations

CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma

1998 • 375 citations

CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia

2000 • 345 citations

Costimulation of CD28- T lymphocytes by 4-1BB ligand.

1997 • 333 citations

CD28-independent, TRAF2-dependent Costimulation of Resting T Cells by 4-1BB Ligand

1998 • 321 citations

Role of 4-1BB in immune responses

1998 • 312 citations

A triad of costimulatory molecules synergize to amplify T-cell activation.

1999 • 293 citations

Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction

2003 • 285 citations

Compromised Ox40 Function in Cd28-Deficient Mice Is Linked with Failure to Develop Cxc Chemokine Receptor 5–Positive Cd4 Cells and Germinal Centers

1999 • 275 citations

Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules.

1993 • 274 citations

Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death.

1997 • 256 citations

Characterization of Human Inducible Costimulator Ligand Expression and Function

2000 • 237 citations

Cutting Edge: Identification of GL50, a Novel B7-Like Protein That Functionally Binds to ICOS Receptor

2000 • 230 citations

Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy

1999 • 223 citations

Danger and OX40 Receptor Signaling Synergize to Enhance Memory T Cell Survival by Inhibiting Peripheral Deletion

2000 • 222 citations

Phase I Study of Recombinant Human CD40 Ligand in Cancer Patients

2001 • 221 citations

Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway

1998 • 218 citations

Phase I clinical trial of a recombinant canarypoxvirus (ALVAC) vaccine expressing human carcinoembryonic antigen and the B7.1 co-stimulatory molecule

2000 • 205 citations

A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes.

1986 • 191 citations

Dendritic Cells Infiltrating Tumors Cotransduced with Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf) and Cd40 Ligand Genes Take up and Present Endogenous Tumor-Associated Antigens, and Prime Naive Mice for a Cytotoxic T Lymphocyte Response

1999 • 184 citations

Induction, binding specificity and function of human ICOS

2000 • 175 citations

The influence of granulocyte macrophage colony-stimulating factor and prior chemotherapy on the immunological response to a vaccine (ALVAC-CEA B7.1) in patients with metastatic carcinoma.

2001 • 173 citations

Pilot study of a dual gene recombinant avipox vaccine containing both carcinoembryonic antigen (CEA) and B7.1 transgenes in patients with recurrent CEA-expressing adenocarcinomas.

2000 • 154 citations

OX-40: life beyond the effector T cell stage

1998 • 152 citations

Enhancement of CD8+ T Cell Responses by ICOS/B7h Costimulation

2001 • 149 citations

Costimulation of tumor-reactive CD4+ and CD8+ T lymphocytes by B7, a natural ligand for CD28, can be used to treat established mouse melanoma.

1994 • 145 citations

Role of Ox40 Signals in Coordinating Cd4 T Cell Selection, Migration, and Cytokine Differentiation in T Helper (Th)1 and Th2 Cells

2000 • 143 citations

Synergy of vaccine strategies to amplify antigen-specific immune responses and antitumor effects.

2001 • 137 citations

Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS

2000 • 132 citations

Interleukin‐12 and B7.1 co‐stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors

1996 • 130 citations

B7H Costimulates Clonal Expansion of, and Cognate Destruction of Tumor Cells by, CD8+ T Lymphocytes In Vivo

2001 • 120 citations

Presence of the T-cell activation marker OX-40 on tumor infiltrating lymphocytes and draining lymph node cells from patients with melanoma and head and neck cancers

1997 • 119 citations

Vaccine-based therapy directed against carcinoembryonic antigen demonstrates antitumor activity on spontaneous intestinal tumors in the absence of autoimmunity.

2002 • 119 citations

B7-1 and interleukin 12 synergistically induce effective antitumor immunity.

1995 • 118 citations

OX40 Ligation Enhances Primary and Memory Cytotoxic T Lymphocyte Responses in an Immunotherapy for Hepatic Colon Metastases

2002 • 115 citations

The right place at the right time: novel B7 family members regulate effector T cell responses

2002 • 113 citations

LICOS, a primordial costimulatory ligand?

2000 • 109 citations

A Dual-Function DNA Vaccine Encoding Carcinoembryonic Antigen and CD40 Ligand Trimer Induces T Cell-Mediated Protective Immunity Against Colon Cancer in Carcinoembryonic Antigen-Transgenic Mice

2001 • 108 citations

Protective immunity induced by tumor vaccines requires interaction between CD40 and its ligand, CD154.

1997 • 106 citations

Rejection of Syngeneic Colon Carcinoma by CTLs Expressing Single-Chain Antibody Receptors Codelivering CD28 Costimulation

2002 • 105 citations

Vector-based vaccine/cytokine combination therapy to enhance induction of immune responses to a self-antigen and antitumor activity.

2002 • 96 citations

Induction of Anti-Mammary Cancer Immunity by Engaging the OX-40 Receptor in Vivo

2001 • 80 citations

CTLA-4 Blockade Enhances the Therapeutic Effect of an Attenuated Poxvirus Vaccine Targeting p53 in an Established Murine Tumor Model

2003 • 77 citations

In vivo gene transfer of CD40 ligand into colon cancer cells induces local production of cytokines and chemokines, tumor eradication and protective antitumor immunity

2000 • 75 citations

OX40 Ligand-Transduced Tumor Cell Vaccine Synergizes with GM-CSF and Requires CD40-Apc Signaling to Boost the Host T Cell Antitumor Response

2003 • 67 citations

Antitumor Responses Induced by Transgenic Expression of CD40 Ligand

1997 • 66 citations

Enhanced activation of human T cells via avipox vector-mediated hyperexpression of a triad of costimulatory molecules in human dendritic cells.

2001 • 65 citations

Induction of CTL Responses by Simultaneous Administration of Liposomal Peptide Vaccine with Anti-CD40 and Anti-CTLA-4 mAb

2000 • 61 citations

In situ expression of B7 and CD28 receptor families in human malignant melanoma: Relevance for T‐cell‐mediated anti‐tumor immunity

1995 • 57 citations

Antitumor Immunity After Vaccination With B Lymphoma Cells Overexpressing a Triad of Costimulatory Molecules

2003 • 48 citations

Enhancement of the anti-tumor immune response using a combination of interferon-γ and B7 expression in an experimental mammary carcinoma

1998 • 47 citations

Adenovirus-mediated CD40 ligand gene-engineered dendritic cells elicit enhanced CD8+ cytotoxic T-cell activation and antitumor immunity

2002 • 43 citations

Potent activity of soluble B7RP‐1‐Fc in therapy of murine tumors in syngeneic hosts

2002 • 31 citations

B7-1, IFNγ and anti-CTLA-4 co-operate to prevent T-cell tolerization during immunotherapy against a murine T-lymphoma

2000 • 28 citations

Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-γ gene into lung cancer

2001 • 28 citations

Pillars article: T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. 1990. Proc. Natl. Acad. Sci. USA 87: 5031-5035.

2009 • 22 citations

Immunotherapy for murine K1735 melanoma: Combinatorial use of recombinant adenovirus expressing CD40L and other immunomodulators

2002 • 22 citations

In vivo induction of antitumor immunity and protection against tumor growth by injection of CD154-expressing tumor cells

2002 • 15 citations