Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-γ gene into lung cancer

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40.

1993 • 593 citations

A New Era for Cancer Immunotherapy Based on the Genes that Encode Cancer Antigens

1999 • 578 citations

Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: up-regulation of interleukin 10 and down-regulation of interleukin 12 production.

1998 • 498 citations

Functions of CD40 on B cells, dendritic cells and other cells

1997 • 490 citations

High-level IL-12 production by human dendritic cells requires two signals

1998 • 424 citations

Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40

1999 • 409 citations

Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses

1996 • 341 citations

Human tumor antigens for cancer vaccine development

1999 • 298 citations

Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1

1999 • 245 citations

The Immune System in the Elderly: Activation-Induced and Damage-Induced Apoptosis

2004 • 204 citations

Dendritic Cells Infiltrating Tumors Cotransduced with Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf) and Cd40 Ligand Genes Take up and Present Endogenous Tumor-Associated Antigens, and Prime Naive Mice for a Cytotoxic T Lymphocyte Response

1999 • 184 citations

Breast cancer–associated antigen, DF3/MUC1, induces apoptosis of activated human T cells

1996 • 166 citations

Effects of TGF-β on the immune system: implications for cancer immunotherapy

1999 • 159 citations

Depletion of IL-10- and TGF-beta-producing regulatory gamma delta T cells by administering a daunomycin-conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells.

1999 • 144 citations

Antimetastatic vaccination of tumor-bearing mice with two types of IFN-gamma gene-inserted tumor cells.

1993 • 142 citations

Inhibition of Human Breast Carcinoma Growth by a Soluble Recombinant Human CD40 Ligand

1999 • 140 citations

The immune system in the elderly

1999 • 128 citations

Tumor expression of Fas ligand (CD95L) and the consequences

1998 • 126 citations

Depletion of IL-10- and TGF-β-Producing Regulatory γδ T Cells by Administering a Daunomycin-Conjugated Specific Monoclonal Antibody in Early Tumor Lesions Augments the Activity of CTLs and NK Cells

1999 • 123 citations

Protective immunity induced by tumor vaccines requires interaction between CD40 and its ligand, CD154.

1997 • 106 citations

Interleukin-10: a cytokine used by tumors to escape immunosurveillance

1999 • 102 citations

Antitumor Effect of CD40 Ligand: Elicitation of Local and Systemic Antitumor Responses by IL-12 and B7

1998 • 90 citations

CONTROL OF PIGMENT PRODUCTION IN MOUSE MELANOMA CELLS IN VITRO

1969 • 84 citations

What is the real role of CD40 in cancer immunotherapy?

1999 • 77 citations

Antitumor Responses Induced by Transgenic Expression of CD40 Ligand

1997 • 66 citations

Autocrine IL-12 Is Involved in Dendritic Cell Modulation Via CD40 Ligation

1999 • 66 citations

CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth

1999 • 53 citations

Synergistic Action of fms-Like Tyrosine Kinase 3 Ligand and CD40 Ligand in the Induction of Dendritic Cells and Generation of Antitumor Immunity In Vivo

1999 • 53 citations

Activation of CD40 Favors the Growth and Vascularization of Kaposi’s Sarcoma

1999 • 40 citations

Enhancement of tumoricidal activity of alveolar macrophages via CD40-CD40 ligand interaction

1999 • 38 citations

Calcium-independent pathway of tumor necrosis factor-mediated lysis of target cells.

1989 • 34 citations

ENZYMATIC DETERMINATION OF TRANSMISSIBLE REPLICATING FACTORS ASSOCIATED WITH MOUSE TUMORS*

1963 • 30 citations

ENZYMATIC DETERMINATION OF TRANSMISSIBLE REPLICATING FACTORS ASSOCIATED WITH MOUSE TUMORS*

1963 • 23 citations

Gene therapy for lung cancer

1995 • 19 citations