Emerging and diverse roles of protein kinase C in immune cell signalling

NF-κB at the crossroads of life and death

2002 • 2,684 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions

2001 • 966 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

New insights into the regulation of protein kinase C and novel phorbol ester receptors

1999 • 600 citations

Defective T Cell Differentiation in the Absence of Jnk1

1998 • 590 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure

2001 • 551 citations

Immunodeficiency in Protein Kinase Cβ-Deficient Mice

1996 • 444 citations

Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ

2002 • 411 citations

Activation of IκB Kinase β by Protein Kinase C Isoforms

1999 • 366 citations

Protein Kinase Cθ in T Cell Activation

2002 • 351 citations

CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation

2002 • 338 citations

The MAGUK Family Protein CARD11 Is Essential for Lymphocyte Activation

2003 • 326 citations

JNK is required for effector T-cell function but not for T-cell activation

2000 • 322 citations

POSITIVE VERSUS NEGATIVE SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

1998 • 320 citations

Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells

2003 • 320 citations

PKC-β controls IκB kinase lipid raft recruitment and activation in response to BCR signaling

2002 • 319 citations

Essential role of RelA Ser311 phosphorylation by PKC in NF- B transcriptional activation

2003 • 317 citations

Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation

2001 • 301 citations

Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development

2003 • 300 citations

Bruton's Tyrosine Kinase Is Required for Activation of Iκb Kinase and Nuclear Factor κb in Response to B Cell Receptor Engagement

2000 • 299 citations

NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

2000 • 291 citations

A requirement for CARMA1 in TCR-induced NF-κB activation

2002 • 288 citations

NF-κB Activation by the Pre-T Cell Receptor Serves as a Selective Survival Signal in T Lymphocyte Development

2000 • 280 citations

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

1998 • 270 citations

Protein kinase Cδ controls self-antigen-induced B-cell tolerance

2002 • 265 citations

Protein kinase C binding partners

2000 • 264 citations

Mechanism of Recruitment of WASP to the Immunological Synapse and of Its Activation Following TCR Ligation

2002 • 261 citations

Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β

2000 • 259 citations

Requirement for CARMA1 in Antigen Receptor-Induced NF-κB Activation and Lymphocyte Proliferation

2003 • 253 citations

Protein Kinase C-θ Isoenzyme Selective Stimulation of the Transcription Factor Complex AP-1 in T Lymphocytes

1996 • 251 citations

Protein Kinase Cϵ Is Required for Macrophage Activation and Defense Against Bacterial Infection

2001 • 241 citations

Protein Kinase C β Controls Nuclear Factor κB Activation in B Cells Through Selective Regulation of the IκB Kinase α

2002 • 239 citations

Wasp in immune-system organization and function

2002 • 216 citations

Bruton's Tyrosine Kinase Links the B Cell Receptor to Nuclear Factor κb Activation

2000 • 215 citations

CARD11 mediates factor-specific activation of NF-κB by the T cell receptor complex

2002 • 206 citations

Xid-like Phenotypes

2000 • 195 citations

Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-κB and NFAT

2001 • 189 citations

Bimp1, a MAGUK Family Member Linking Protein Kinase C Activation to Bcl10-mediated NF-κB Induction

2001 • 182 citations

IKKβ Is Required for Peripheral B Cell Survival and Proliferation

2003 • 177 citations

NF-κB activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-θ

2000 • 169 citations

WIP Deficiency Reveals a Differential Role for WIP and the Actin Cytoskeleton in T and B Cell Activation

2002 • 166 citations

Crucial importance of PKC-β(I) in LFA-1–mediated locomotion of activated T cells

2001 • 146 citations

PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization

2001 • 143 citations

CD28 plays a critical role in the segregation of PKCθ within the immunologic synapse

2002 • 142 citations

The Physical Association of Protein Kinase Cθ with a Lipid Raft-Associated Inhibitor of κB Factor Kinase (IKK) Complex Plays a Role in the Activation of the NF-κB Cascade by TCR and CD28

2000 • 136 citations

The PKC gene module: molecular biosystematics to resolve its T cell functions

2003 • 134 citations

Role of zetaPKC in B-cell signaling and function

2002 • 132 citations

Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K– and Vav-dependent pathway, but does not absolutely require phospholipase C

2002 • 131 citations

Protein Kinase C-δ Is a Negative Regulator of Antigen-Induced Mast Cell Degranulation

2002 • 131 citations

Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death.

1999 • 131 citations

Inhibition of degranulation and interleukin-6 production in mast cells derived from mice deficient in protein kinase Cβ

2000 • 125 citations

Protein Kinase Cα (PKCα) Acts Upstream of PKCθ To Activate IκB Kinase and NF-κB in T Lymphocytes

2003 • 120 citations

Regulation of Protein Kinase Cθ Function during T Cell Activation by Lck-mediated Tyrosine Phosphorylation

2000 • 118 citations

Kinases as therapeutic targets for heart failure

2003 • 113 citations

Functional effects of overexpression of protein kinase C-alpha, -beta, -delta, -epsilon, and -eta in the mast cell line RBL-2H3.

1997 • 105 citations

Protein kinase C-θ: signaling from the center of the T-cell synapse

2002 • 104 citations

Protein Kinase Cε Is Required for the Induction of Mitogen-Activated Protein Kinase Phosphatase-1 in Lipopolysaccharide-Stimulated Macrophages

2000 • 102 citations

Nerve Growth Factor Stimulates Multisite Tyrosine Phosphorylation and Activation of the Atypical Protein Kinase C's via a src Kinase Pathway

2001 • 96 citations

Protein kinase C inhibitors

2002 • 94 citations

The regulation of actin remodeling during T‐cell–APC conjugate formation

2002 • 89 citations

T-cell activation: a multidimensional signaling network

2002 • 84 citations

Regulation of protein kinase CβI by two protein-tyrosine kinases, Btk and Syk

2000 • 82 citations

Inside the crawling T cell: leukocyte function-associated antigen-1 cross-linking is associated with microtubule-directed translocation of protein kinase C isoenzymes beta(I) and delta.

1998 • 78 citations

Complex Formation and Cooperation of Protein Kinase Cθ and Akt1/Protein Kinase Bα in the NF-κB Transactivation Cascade in Jurkat T Cells

2001 • 77 citations

A Ras activation pathway dependent on Syk phosphorylation of protein kinase C

2003 • 76 citations

Up-Regulation of Protein Kinase C-ϵ Promotes the Expression of Cytokine-inducible Nitric Oxide Synthase in RAW 264.7 Cells

1996 • 74 citations

ZAP-70 and SLP-76 Regulate Protein Kinase C-θ and NF-κB Activation in Response to Engagement of CD3 and CD28

2001 • 74 citations

PKCζ participates in activation of inflammatory response induced by enteropathogenicE. coli

2003 • 69 citations

Phosphorylation of the gamma chain of the high affinity receptor for immunoglobulin E by receptor-associated protein kinase C-delta.

1994 • 64 citations

PKCε is a permissive link in integrin-dependent IFN-γ signalling that facilitates JAK phosphorylation of STAT1

2003 • 64 citations

NF-κB Is Required for the Positive Selection of CD8+ Thymocytes

2000 • 60 citations

T cell expressed PKCθ demonstrates cell‐type selective function

2000 • 59 citations

Activation of NFAT-Dependent Gene Expression by Nef: Conservation among Divergent Nef Alleles, Dependence on SH3 Binding and Membrane Association, and Cooperation with Protein Kinase C-θ

2001 • 54 citations

T cell expressed PKCθ demonstrates cell-type selective function

2000 • 50 citations

Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes

2001 • 49 citations

Critical role of protein kinase C ε for lipopolysaccharide-induced IL-12 synthesis in monocyte-derived dendritic cells

2002 • 48 citations

Inhibition of nitric oxide synthesis by interleukin‐4 may involve inhibiting the activation of protein kinase C epsilon

1994 • 48 citations

Accelerated proliferation and interleukin-2 production of thymocytes by stimulation of soluble anti-CD3 monoclonal antibody in transgenic mice carrying a rabbit protein kinase C alpha.

1992 • 33 citations

The family of protein kinase C and membrane lipid mediators

2002 • 32 citations

Intrinsic Activity of Guanosine 3′,5′-Monophosphate-dependent Protein Kinase Similar to Adenosine 3′,5′-Monophosphatedependent Protein Kinase

1977 • 24 citations