Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

1999 • 1,880 citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 • 1,786 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

Translating cell biology into therapeutic advances in Alzheimer's disease

1999 • 1,592 citations

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

1996 • 1,013 citations

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing

2000 • 906 citations

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

2001 • 876 citations

Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

2000 • 861 citations

γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase

2001 • 848 citations

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

2002 • 676 citations

Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state

2000 • 526 citations

A γ‐secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

2002 • 493 citations

A Portrait of Alzheimer Secretases--New Features and Familiar Faces

2001 • 492 citations

Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells

2000 • 480 citations

Laying it on thick

1999 • 471 citations

Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

2001 • 471 citations

beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.

1993 • 460 citations

Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1

2000 • 407 citations

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

2002 • 406 citations

Maturation and Endosomal Targeting of β-Site Amyloid Precursor Protein-cleaving Enzyme

2000 • 404 citations

Mutagenesis Identifies New Signals for β-Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including Aβ42

1999 • 381 citations

The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex

1998 • 329 citations

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

1997 • 321 citations

Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons

1999 • 310 citations

A Loss of Function Mutation of Presenilin-2 Interferes with Amyloid β-Peptide Production and Notch Signaling

1999 • 306 citations

Aβ-Generating Enzymes

2000 • 298 citations

Phosphorylation, Subcellular Localization, and Membrane Orientation of the Alzheimer's Disease-associated Presenilins

1997 • 291 citations

Proteolytic Processing of Low Density Lipoprotein Receptor-related Protein Mediates Regulated Release of Its Intracellular Domain

2002 • 286 citations

Lighting up the cell surface with evanescent wave microscopy

2001 • 279 citations

Phosphorylation Regulates Intracellular Trafficking of β-Secretase

2001 • 275 citations

Cell Surface Presenilin-1 Participates in the γ-Secretase-like Proteolysis of Notch

1999 • 268 citations

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

2000 • 263 citations

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ ₄₂ production

2002 • 263 citations

The Transmembrane Aspartates in Presenilin 1 and 2 Are Obligatory for γ-Secretase Activity and Amyloid β-Protein Generation

2000 • 253 citations

Maturation and Pro-peptide Cleavage of β-Secretase

2000 • 247 citations

Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation

2002 • 232 citations

The Alzheimer’s Disease-Associated Presenilins Are Differentially Phosphorylated Proteins Located Predominantly within the Endoplasmic Reticulum

1996 • 229 citations

Presenilin-1 Forms Complexes with the Cadherin/Catenin Cell–Cell Adhesion System and Is Recruited to Intercellular and Synaptic Contacts

1999 • 221 citations

Microtubule-dependent transport of secretory vesicles visualized in real time with a GFP-tagged secretory protein

1997 • 208 citations

Endoproteolytic Processing and Stabilization of Wild-type and Mutant Presenilin

1997 • 205 citations

Are Presenilins Intramembrane-Cleaving Proteases? Implications for the Molecular Mechanism of Alzheimer's Disease

1999 • 201 citations

Presenilin 1 Is Required for Maturation and Cell Surface Accumulation of Nicastrin

2002 • 184 citations

Murine Notch Homologs (N1–4) Undergo Presenilin-dependent Proteolysis

2001 • 176 citations

Nicastrin Is Required for γ-Secretase Cleavage of the Drosophila Notch Receptor

2002 • 168 citations

The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein

2001 • 161 citations

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

2001 • 151 citations

Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch

2000 • 148 citations

Trafficking of cell-surface amyloid β-protein precursor: II. Endocytosis, recycling, and lysosomal targeting detected by immunolocalization

1996 • 132 citations

Improved electrophoretic separation and immunoblotting of beta‐amyloid (Aβ) peptides 1–40, 1–42, and 1–43

1997 • 131 citations

The Role of Presenilins in γ-Secretase Activity

2001 • 131 citations

The Biological and Pathological Function of the Presenilin-1 ΔExon 9 Mutation Is Independent of Its Defect to Undergo Proteolytic Processing

1999 • 129 citations

Drosophila Nicastrin Is Essential for the Intramembranous Cleavage of Notch

2002 • 124 citations

Multiple Effects of Aspartate Mutant Presenilin 1 on the Processing and Trafficking of Amyloid Precursor Protein

2001 • 103 citations

Amyloidogenic Function of the Alzheimer's Disease-Associated Presenilin 1 in the Absence of Endoproteolysis

1999 • 92 citations

Endogenous Presenilin-1 Targets to Endocytic Rather Than Biosynthetic Compartments

2000 • 84 citations

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

1999 • 65 citations

The Nonconserved Hydrophilic Loop Domain of Presenilin (PS) Is Not Required for PS Endoproteolysis or Enhanced Aβ42 Production Mediated by Familial Early Onset Alzheimer's Disease-linked PS Variants

2000 • 64 citations

APH-2/Nicastrin Functions in LIN-12/Notch Signaling in the Caenorhabditis elegans Somatic Gonad

2001 • 47 citations

The multiple paradoxes of presenilins

2001 • 47 citations

Localization of Alzheimer-Associated Presenilin 1 in Transfected COS-7 Cells

1996 • 46 citations

Enrichment of Presenilin 1 Peptides in Neuronal Large Dense‐Core and Somatodendritic Clathrin‐Coated Vesicles

1998 • 43 citations

The Role of Alzheimer's Disease-Related Presenilin 1 in Intercellular Adhesion

2001 • 30 citations