Murine Notch Homologs (N1–4) Undergo Presenilin-dependent Proteolysis

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

1999 • 1,880 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

Notch signaling is essential for vascular morphogenesis in mice

2000 • 1,042 citations

Notch Signaling: From the Outside In

2000 • 958 citations

Notch1 is required for the coordinate segmentation of somites

1995 • 860 citations

A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1

2000 • 841 citations

Notch1 is essential for postimplantation development in mice.

1994 • 731 citations

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1999 • 517 citations

Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

1996 • 497 citations

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1996 • 481 citations

Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells

2000 • 480 citations

Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

2001 • 471 citations

Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects

1999 • 462 citations

Requirements for Presenilin-Dependent Cleavage of Notch and Other Transmembrane Proteins

2000 • 418 citations

Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1

2000 • 407 citations

Alterations in Notch signaling in neoplastic lesions of the human cervix.

1995 • 355 citations

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1

2000 • 323 citations

A Loss of Function Mutation of Presenilin-2 Interferes with Amyloid β-Peptide Production and Notch Signaling

1999 • 306 citations

Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease

1999 • 290 citations

Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality

1999 • 277 citations

Notch as a Mediator of Cell Fate Determination in Hematopoiesis: Evidence and Speculation

1999 • 265 citations

Mechanism of the cleavage specificity of Alzheimer’s disease γ-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

1999 • 229 citations

Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos

1998 • 217 citations

Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis.

1996 • 210 citations

The NOTCH4 locus is associated with susceptibility to schizophrenia

2000 • 180 citations

Notch Signaling in Vertebrate Development and Disease

1997 • 170 citations

Evidence for a physical interaction between presenilin and Notch

1999 • 168 citations

Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2

2000 • 164 citations

γ-Secretase, Evidence for Multiple Proteolytic Activities and Influence of Membrane Positioning of Substrate on Generation of Amyloid β Peptides of Varying Length

1999 • 155 citations

Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development

1996 • 120 citations

Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma

1996 • 115 citations

Identification of a novel NOTCH-4/INT-3 RNA species encoding an activated gene product in certain human tumor cell lines

2000 • 105 citations

NOTCH4 gene polymorphism and susceptibility to schizophrenia and schizoaffective disorder

2001 • 54 citations

Evidence that an IRES within the Notch2 Coding Region Can Direct Expression of a Nuclear Form of the Protein

2000 • 47 citations