Molecular mechanism of transforming growth factor β–mediated cell-cycle modulation in primary human CD34+ progenitors

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells

1987 • 407 citations

T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates

1998 • 334 citations

D-Type Cyclin-Dependent Kinase Activity in Mammalian Cells

1994 • 322 citations

Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells.

1989 • 316 citations

Cell Cycle-Related Changes in Repopulating Capacity of Human Mobilized Peripheral Blood CD34+ Cells in Non-Obese Diabetic/Severe Combined Immune-Deficient Mice

1998 • 302 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer

1991 • 292 citations

Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progenitor population

1996 • 281 citations

The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.

1992 • 274 citations

Sustained human hematopoiesis in immunodeficient mice by cotransplantation of marrow stroma expressing human interleukin-3: analysis of gene transduction of long-lived progenitors

1994 • 264 citations

The Fluctuating Phenotype of the Lymphohematopoietic Stem Cell with Cell Cycle Transit

1998 • 229 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. I. Stimulatory role of a variety of mesenchymal cell activators and inhibitory role of TGF-beta

1990 • 227 citations

Human hematopoietic stem cells stimulated to proliferate in vitro lose engraftment potential during their S/G2/M transit and do not reenter G0

2000 • 212 citations

TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes.

1995 • 209 citations

Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-β2 microglobulin–null mice

2001 • 204 citations

Transduction of Human Progenitor Hematopoietic Stem Cells by Human Immunodeficiency Virus Type 1-Based Vectors Is Cell Cycle Dependent

1999 • 199 citations

Functional Heterogeneity of Human CD34+ Cells Isolated in Subcompartments of the G0 /G1 Phase of the Cell Cycle

1997 • 199 citations

Transduction of pluripotent human hematopoietic stem cells demonstrated by clonal analysis after engraftment in immune-deficient mice.

1996 • 186 citations

Regulation of G1/S transition by cyclins D2 and D3 in hematopoietic cells.

1993 • 179 citations

Retroviral Transfer of the Glucocerebrosidase Gene into CD34⁺Cells from Patients with Gaucher Disease:In VivoDetection of Transduced Cells without Myeloablation

1998 • 171 citations

Adhesion to Fibronectin Maintains Regenerative Capacity During Ex Vivo Culture and Transduction of Human Hematopoietic Stem and Progenitor Cells

1998 • 168 citations

TGF-β1 maintains hematopoietic immaturity by a reversible negative control of cell cycle and induces CD34 antigen up-modulation

2000 • 148 citations

High-resolution cell cycle analysis of defined phenotypic subsets within primitive human hematopoietic cell populations.

1996 • 147 citations

Reduction in levels of the cyclin-dependent kinase inhibitor p27 ^kip-1 coupled with transforming growth factor β neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells

1998 • 119 citations

In Vitro Identification of Single CD34+CD38− Cells With Both Lymphoid and Myeloid Potential

1998 • 99 citations

Engraftment and Retroviral Marking of CD34+ and CD34+CD38− Human Hematopoietic Progenitors Assessed in Immune-Deficient Mice

1998 • 86 citations

Maintenance of murine long-term repopulating stem cells in ex vivo culture is affected by modulation of transforming growth factor-beta but not macrophage inflammatory protein-1 alpha activities

1996 • 76 citations

Retroviral vector-mediated gene transfer into primitive human hematopoietic progenitor cells: effects of mast cell growth factor (MGF) combined with other cytokines.

1992 • 72 citations

TGF-beta 1 induces the cyclin-dependent kinase inhibitor p27Kip1 mRNA and protein in murine B cells.

1998 • 65 citations

Release from Quiescence of Primitive Human Hematopoietic Stem/Progenitor Cells by Blocking Their Cell‐Surface TGF‐β Type II Receptor in a Short‐Term In Vitro Assay

2000 • 62 citations

Long‐Term Cytokine Production from Engineered Primary Human Stromal Cells Influences Human Hematopoiesis in an In Vivo Xenograft Model

1997 • 59 citations

TGF-β1 Induces the Cyclin-Dependent Kinase Inhibitor p27Kip1 mRNA and Protein in Murine B Cells

1998 • 58 citations

Inhibition of cell growth by TGF beta 1 is associated with inhibition of B-myb and cyclin A in both BALB/MK and Mv1Lu cells.

1994 • 47 citations

Functional association of TGF-β receptor II with cyclin B

1999 • 43 citations

Expression of G1-Phase Cell Cycle Genes during Hematopoietic Lineage

1997 • 40 citations

Discovery of a Regulatory Motif That Controls the Exposure of Specific Upstream Cyclin-dependent Kinase Sites That Determine Both Conformation and Growth Suppressing Activity of pRb

1999 • 36 citations

Cdk4 integrates growth stimulatory and inhibitory signals during G1 phase of hematopoietic cells.

1995 • 34 citations

Gene Therapy for Adenosine Deaminase Deficiency

2000 • 33 citations

Transforming growth factor-beta regulates the cell cycle status of interleukin-3 (IL-3) plus IL-1, stem cell factor, or IL-6 stimulated CD34+ human hematopoietic progenitor cells through different cell kinetic mechanisms depending on the applied stimulus.

1994 • 28 citations

Retroviral-Mediated Gene Transduction of c-kit Into Single Hematopoietic Progenitor Cells From Cord Blood Enhances Erythroid Colony Formation and Decreases Sensitivity to Inhibition by Tumor Necrosis Factor- and Transforming Growth Factor-β1

1999 • 27 citations

Gene therapy for hematopoietic and immune disorders.

1996 • 25 citations

Additive effects of steel factor and antisense TGF-beta 1 oligodeoxynucleotide on CD34+ hematopoietic progenitor cells.

1994 • 24 citations

Molecular control of cell cycle progression in primary human hematopoietic stem cells: methods to increase levels of retroviral-mediated transduction

1999 • 22 citations

Abrogation of TGF-β activity during retroviral transduction improves murine hematopoietic progenitor and repopulating cell gene transfer efficiency

1998 • 17 citations

Stem cell engraftment and cell cycle phenotype

1999 • 5 citations