Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice

Disruption of imprinting caused by deletion of the H19 gene region in mice

1995 • 765 citations

Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome

1997 • 753 citations

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2

1998 • 641 citations

Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development.

1997 • 496 citations

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.

1993 • 493 citations

Chromosome engineering in mice

1995 • 479 citations

Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells

1997 • 438 citations

A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith–Wiedemann syndrome

1999 • 405 citations

An imprinted gene p57KIP2 is mutated in Beckwith–Wiedemann syndrome

1996 • 390 citations

Loss of imprinting of a paternally expressed transcript, with antisense orientation to K _V LQT1, occurs frequently in Beckwith–Wiedemann syndrome and is independent of insulin-like growth factor II imprinting

1999 • 360 citations

Beckwith-Wiedemann syndrome: imprinting in clusters revisited

2000 • 299 citations

Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice

2000 • 297 citations

A site–directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination

1995 • 257 citations

Multiple Mechanisms Regulate Imprinting of the Mouse Distal Chromosome 7 Gene Cluster

1998 • 245 citations

Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange– Nielsen Syndrome

2001 • 244 citations

LIT1, an imprinted antisense RNA in the human KvLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids

1999 • 229 citations

Engineering Mouse Chromosomes with Cre-loxP: Range, Efficiency, and Somatic Applications

2000 • 202 citations

Targeted disruption of the human LIT1 locus defines a putative imprinting control element playing an essential role in Beckwith-Wiedemann syndrome

2000 • 178 citations

The IPL Gene on Chromosome 11p15.5 is Imprinted in Humans and Mice and is Similar to TDAG51, Implicated in Fas Expression and Apoptosis

1997 • 164 citations

Cre-mediated site-specific translocation between nonhomologous mouse chromosomes.

1995 • 148 citations

Low Frequency of p57KIP2 Mutation in Beckwith-Wiedemann Syndrome

1997 • 141 citations

Coding Mutations in p57 Are Present in Some Cases of Beckwith-Wiedemann Syndrome but Are Rare or Absent in Wilms Tumors

1997 • 140 citations

Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse

2000 • 128 citations

Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway

1996 • 127 citations

Sequence and Comparative Analysis of the Mouse 1-Megabase Region Orthologous to the Human 11p15 Imprinted Domain

2000 • 113 citations

IMPT1, an imprinted gene similar to polyspecific transporter and multi- drug resistance genes

1998 • 101 citations

Divergently Transcribed Overlapping Genes Expressed in Liver and Kidney and Located in the 11p15.5 Imprinted Domain

1998 • 68 citations

Mothers Setting Boundaries

2000 • 22 citations

Sequence-based Structural Features between Kvlqt1 and Tapa1 on Mouse Chromosome 7F4/F5 Corresponding to the Beckwith-Wiedemann Syndrome Region on Human 11p15.5 : long-stretches of Unusually Well Conserved Intronic Sequences of Kvlqt1 between Mouse and Human

2000 • 15 citations