Smad-mediated Transcription Is Required for Transforming Growth Factor-β1-induced p57Kip2 Proteolysis in Osteoblastic Cells

THE UBIQUITIN SYSTEM

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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SCF and Cullin/RING H2-Based Ubiquitin Ligases

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Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

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Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome

1997 • 753 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

Whose end is destruction: cell division and the anaphase-promoting complex

1999 • 679 citations

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

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Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro.

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Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

1994 • 558 citations

Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development.

1997 • 496 citations

Cell-cycle inhibitors: three families united by a common cause

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A ubiquitin ligase complex essential for the NF-kappa B, Wnt/Wingless, and Hedgehog signaling pathways

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Regulation of Smad Activity

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Roles of Bone Morphogenetic Protein Type I Receptors and Smad Proteins in Osteoblast and Chondroblast Differentiation

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TGF-β signaling by Smad proteins

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Target cells in bone for parathormone and calcitonin are different: enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces.

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Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells.

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Smads bind directly to the Jun family of AP-1 transcription factors

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Transforming Growth Factor β Activation of p44mapk in Proliferating Cultures of Epithelial Cells

1995 • 312 citations

Evidence for a Role of Rho-like GTPases and Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) in Transforming Growth Factor β-mediated Signaling

1997 • 301 citations

Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism

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Ubiquitination and Degradation of the Substrate Recognition Subunits of SCF Ubiquitin–Protein Ligases

1998 • 259 citations

The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts

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The Role of p38 MAP Kinase in TGF-β1-Induced Signal Transduction in Human Neutrophils

1998 • 107 citations

p57Kip2 Is Degraded through the Proteasome in Osteoblasts Stimulated to Proliferation by Transforming Growth Factor β1

1999 • 85 citations