Radiation-induced normal tissue injury: Role of adhesion molecules in leukocyte-endothelial cell interactions

Adhesion receptors of the immune system

1990 • 6,585 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins

1989 • 2,045 citations

Cancer: Principles and Practice of Oncology

1994 • 1,825 citations

Selectins and their ligands: current concepts and controversies

1996 • 1,446 citations

Endothelial-Leukocyte Adhesion Molecules

1993 • 1,324 citations

PECAM-1 is required for transendothelial migration of leukocytes.

1993 • 1,134 citations

The inducible transcription activator NF-κB: regulation by distinct protein subunits

1991 • 1,079 citations

α4 integrins mediate lymphocyte attachment and rolling under physiologic flow

1995 • 1,018 citations

Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo.

1991 • 977 citations

A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation.

1985 • 886 citations

Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice

1994 • 835 citations

Regulation of Rransendothelial Neutrophil Migration by Endogenous Interleukin-8

1991 • 813 citations

Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury

1988 • 794 citations

Intercellular adhesion molecule-1

1996 • 788 citations

Endothelial cell interactions with granulocytes: tethering and signaling molecules

1992 • 773 citations

The integrin VLA-4 supports tethering and rolling in flow on VCAM-1.

1995 • 716 citations

Involvement of Platelet-Endothelial Cell Adhesion Molecule-1 in Neutrophil Recruitment in Vivo

1993 • 468 citations

A platelet membrane protein expressed during platelet activation and secretion. Studies using a monoclonal antibody specific for thrombin-activated platelets.

1984 • 426 citations

Ionizing radiation induces expression and binding activity of the nuclear factor kappa B.

1991 • 410 citations

Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion.

1991 • 406 citations

Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins.

1994 • 391 citations

Characterization of E-selectin-deficient mice: Demonstration of overlapping function of the endothelial selectins

1994 • 384 citations

CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium.

1995 • 367 citations

Inhibition of nitric oxide production. Mechanisms of vascular albumin leakage.

1993 • 352 citations

Endothelial-leukocyte adhesion molecule 1 stimulates the adhesive activity of leukocyte integrin CR3 (CD11b/CD18, Mac-1, alpha m beta 2) on human neutrophils.

1991 • 347 citations

Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells.

1993 • 340 citations

Neutrophils roll on E-selectin.

1993 • 339 citations

Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions.

1996 • 334 citations

Molecular determinants of reperfusion-induced leukocyte adhesion and vascular protein leakage.

1994 • 328 citations

Cell adhesion molecules mediate radiation-induced leukocyte adhesion to the vascular endothelium.

1996 • 296 citations

Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo.

1994 • 296 citations

A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit

1991 • 284 citations

Neutrophils roll on adherent neutrophils bound to cytokine-induced endothelial cells via L-selectin on the rolling cells.

1994 • 279 citations

Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase- dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes

1993 • 260 citations

The Response of the Microvascular System to Radiation: A Review

1989 • 250 citations

Pathogenesis of radiation-induced myocardial fibrosis.

1973 • 234 citations

Margination of leukocytes in blood flow through small tubes

1984 • 230 citations

L-selectin (CD62L) cross-linking signals neutrophil adhesive functions via the Mac-1 (CD11b/CD18) beta 2-integrin.

1995 • 228 citations

Expression of P-selectin on Endothelial Cells is Upregulated by LPS and TNF-α in Vivo

1994 • 226 citations

Interactions through L-selectin between leukocytes and adherent leukocytes nucleate rolling adhesions on selectins and VCAM-1 in shear flow.

1996 • 210 citations

Indomethacin-induced leukocyte adhesion in mesenteric venules: role of lipoxygenase products

1992 • 206 citations

Regulation of leukocyte rolling and adhesion to high endothelial venules through the cytoplasmic domain of L-selectin.

1993 • 206 citations

Identification of αvβ3 as a heterotypic ligand for CD31/PECAM-1

1996 • 197 citations

Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1

1991 • 192 citations

The role of PECAM-1 (CD31) in leukocyte emigration: studies in vitro and in vivo

1995 • 183 citations

Endothelial-dependent Mechanisms Regulate Leukocyte Transmigration: A Process Involving the Proteasome and Disruption of the Vascular Endothelial–Cadherin Complex at Endothelial Cell-to-Cell Junctions

1997 • 182 citations

Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migration and beta 2 integrin activation.

1996 • 180 citations

A novel β ₁ ‐dependent adhesion pathway on neutrophils: a mechanism invoked by dihydrocytochalasin B or endothelial transmigration

1995 • 180 citations

Intercellular adhesion molecule 1 knockout abrogates radiation induced pulmonary inflammation

1997 • 170 citations

Radiation-Induced Vascular Injury and Its Relation to Late Effects in Normal Tissues

1981 • 170 citations

Ligation of platelet/endothelial cell adhesion molecule 1 (PECAM-1/CD31) on monocytes and neutrophils increases binding capacity of leukocyte CR3 (CD11b/CD18).

1995 • 169 citations

Molecular cloning and analysis of in vivo expression of murine P- selectin

1992 • 165 citations

A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31).

1992 • 160 citations

Late and persistent up-regulation of intercellular adhesion molecule-1 (ICAM-1) expression by ionizing radiation in human endothelial cells in vitro

1997 • 159 citations

L- and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-alpha-activated vascular endothelium under flow in vitro.

1996 • 157 citations

L-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectin

1993 • 142 citations

Vascular Activation of Adhesion Molecule mRNA and Cell Surface Expression by Ionizing Radiation

1998 • 130 citations

E-Selectin Gene Induction by Ionizing Radiation Is Independent of Cytokine Induction

1995 • 128 citations

Capillary Injury Preceding Radiation-Induced Myocardial Fibrosis

1971 • 128 citations

Ionizing Radiation Enhances Platelet Adhesion to the Extracellular Matrix of Human Endothelial Cells by an Increase in the Release of von Willebrand Factor

1994 • 118 citations

Role of leukocyte-endothelial cell adhesion in radiation-induced microvascular dysfunction in rats

1995 • 117 citations

Ionizing radiation mediates expression of cell adhesion molecules in distinct histological patterns within the lung.

1997 • 113 citations

Blockade of platelet endothelial cell adhesion molecule-1 protects against myocardial ischemia and reperfusion injury in cats.

1996 • 110 citations

Structural and Biosynthetic Studies of the Granule Membrane Protein, GMP-140, from Human Platelets and Endothelial Cells

1989 • 107 citations

Lymphocyte adhesion-dependent calcium signaling in human endothelial cells.

1995 • 103 citations

In Vitro Degradation of Endothelial Catenins by a Neutrophil Protease

1998 • 102 citations

Role of Primary and Secondary Capture for Leukocyte Accumulation In Vivo

1998 • 100 citations

E-selectin mediates leukocyte rolling in interleukin-1-treated rabbit mesentery venules

1994 • 98 citations

A pathway to pulmonary fibrosis: an ultrastructural study of mouse and rat following radiation to the whole body and hemithorax.

1970 • 93 citations

Role of Mac-1 and ICAM-1 in ischemia-reperfusion injury in a microcirculation model of BALB/C mice

1994 • 91 citations

Antibody to Platelet/Endothelial Cell Adhesion Molecule-1 Reduces Myocardial Infarct Size in a Rat Model of Ischemia-Reperfusion Injury

1996 • 90 citations

Involvement of adhesion molecules in human monocyte adhesion to and transmigration through endothelial cells in vitro

1994 • 88 citations

PROLIFERATION KINETICS OF THE MOUSE BLADDER AFTER IRRADIATION

1980 • 78 citations

PROLIFERATION STUDIES OF THE ENDOTHELIAL AND SMOOTH MUSCLE CELLS OF THE MOUSE MESENTERY AFTER IRRADIATION

1980 • 77 citations

Ionizing radiation enhances IL‐6 and IL‐8 production by human endothelial cells

1997 • 75 citations

Role of Platelet-Endothelial Cell Adhesion Molecule (PECAM) in Platelet Adhesion/Aggregation Over Injured but Not Denuded Endothelium In Vivo and Ex Vivo

1996 • 75 citations

Changes in the microcirculation of normal tissues after irradiation

1978 • 65 citations

The late vascular effects of radiation

1974 • 62 citations

Neutrophils generate oxygen free radicals in rat mesenteric microcirculation after abdominal irradiation

1996 • 58 citations

Ionizing Radiation Induces, via Generation of Reactive Oxygen Intermediates, Intercellular Adhesion Molecule-1 (ICAM-1) Gene Transcription and NFκB-like Binding Activity in the ICAM-1 Transcriptional Regulatory Region

1997 • 56 citations

Interrelationship between the Early Inflammatory Response and Subsequent Fibrosis after Radiation Exposure

1977 • 51 citations

Inhibition of radiation-induced up-regulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021

1995 • 51 citations

The Pulmonary Response to Sublethal Thoracic Irradiation in the Rat

1993 • 49 citations

Initial contact and subsequent adhesion of human neutrophils or monocytes to human aortic endothelial cells releases an endothelial intracellular calcium store.

1994 • 46 citations

Differences in leucocyte-endothelium interactions between normal and adenocarcinoma bearing tissues in response to radiation

1994 • 46 citations

Sialyl Lewis X Mimetics Attenuate E-Selectin-Mediated Adhesion of Leukocytes to Irradiated Human Endothelial Cells

1997 • 45 citations

Irradiation Induces Upregulation of CD31 in Human Endothelial Cells

1999 • 42 citations

The Chronological Development of Late Radiation Injury in the Liver of the Rat

1980 • 38 citations

Ethanol enhances leukocyte-endothelial cell interactions in mesenteric venules

1990 • 36 citations

Sequential Evaluation of Radiation-Induced Glomerular Ultrastructural Changes in the Pig Kidney

1993 • 29 citations

Radiation Skin Reaction and Depletion and Restoration of Body Immune Response

1963 • 22 citations

Morphologic and morphometric analysis of the early effects of x-ray and heavy-ion irradiation of hamster lung.

1976 • 19 citations

Deleted Work

1955 • 0 citations