Contribution of stem cells and differentiated cells to epidermal tumours

Prospective identification of tumorigenic breast cancer cells

2003 • 10,067 citations

Stem cells, cancer, and cancer stem cells

2001 • 9,488 citations

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1997 • 6,760 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

Histopathology of the skin

1975 • 2,630 citations

Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1997 • 2,063 citations

The Hedgehog and Wnt signalling pathways in cancer

2001 • 1,374 citations

Activating Smoothened mutations in sporadic basal-cell carcinoma

1998 • 1,327 citations

β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin

2001 • 1,304 citations

Three clonal types of keratinocyte with different capacities for multiplication.

1987 • 1,271 citations

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression

1993 • 1,102 citations

De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

1998 • 1,082 citations

Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

2000 • 1,063 citations

WNT Signals Are Required for the Initiation of Hair Follicle Development

2002 • 1,013 citations

Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

2001 • 998 citations

Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

1999 • 991 citations

Notch1 functions as a tumor suppressor in mouse skin

2003 • 957 citations

Rules for Making Human Tumor Cells

2002 • 928 citations

Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome

2002 • 882 citations

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

2001 • 849 citations

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

1996 • 756 citations

Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog

1997 • 712 citations

Sticky Business

2003 • 709 citations

Frequent clones of p53-mutated keratinocytes in normal human skin

1996 • 678 citations

Identification of the familial cylindromatosis tumour-suppressor gene

2000 • 654 citations

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

1997 • 633 citations

NEW EMBO MEMBER'S REVIEW: Role of integrins in regulating epidermal adhesion, growth and differentiation

2002 • 616 citations

A common human skin tumour is caused by activating mutations in β-catenin

1999 • 608 citations

Links between signal transduction, transcription and adhesion in epithelial bud development

2003 • 564 citations

Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin

2001 • 551 citations

NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia

2003 • 541 citations

Reversible Activation of c-Myc in Skin

1999 • 468 citations

Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis

2001 • 465 citations

Hyperproliferation and Defects in Epithelial Polarity upon Conditional Ablation of α-Catenin in Skin

2001 • 441 citations

Stimulation of human epidermal differentiation by Delta–Notch signalling at the boundaries of stem-cell clusters

2000 • 440 citations

c-Jun and JunB Antagonistically Control Cytokine-Regulated Mesenchymal–Epidermal Interaction in Skin

2000 • 412 citations

Basal cell carcinomas in mice overexpressing Gli2 in skin

2000 • 396 citations

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours

2002 • 388 citations

Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

2000 • 378 citations

The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis

1999 • 359 citations

Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin

2001 • 342 citations

c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny

2001 • 339 citations

Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

2000 • 330 citations

c-Myc promotes differentiation of human epidermal stem cells

1997 • 318 citations

Deregulated expression of c-Myc depletes epidermal stem cells

2001 • 316 citations

Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development

2003 • 307 citations

The EGF Receptor Provides an Essential Survival Signal for SOS-Dependent Skin Tumor Development

2000 • 305 citations

Sunlight and the onset of skin cancer

1997 • 302 citations

Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours

2002 • 296 citations

Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog

1997 • 277 citations

Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter

1990 • 277 citations

Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis

1988 • 275 citations

Stem-cell hierarchy in skin cancer

2003 • 271 citations

Stem cell fate and patterning in mammalian epidermis

2001 • 250 citations

Hair follicle predetermination

2001 • 226 citations

Pathology of Tumours in Laboratory Animals

1996 • 222 citations

Cultured dermal papilla cells induce follicle formation and hair growth by transdifferentiation of an adult epidermis

1992 • 220 citations

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

2001 • 210 citations

Designer skin: lineage commitment in postnatal epidermis

2002 • 200 citations

Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

2003 • 182 citations

Muir–Torre-like syndrome in Fhit-deficient mice

2000 • 178 citations

Mice Defective in Two Apoptosis Pathways in the Myeloid Lineage Develop Acute Myeloblastic Leukemia

1998 • 173 citations

Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation.

2003 • 172 citations

Hedgehog signalling in cancer

2000 • 172 citations

Escaping the stem cell compartment: Sustained UVB exposure allows p53 -mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations

2001 • 169 citations

Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice.

1996 • 165 citations

A Novel Connexin 26 Mutation in a Patient Diagnosed with Keratitis–Ichthyosis–Deafness Syndrome

2002 • 160 citations

Wnt signals are targets and mediators of Gli function

2001 • 160 citations

Activation of Expression of Hedgehog Target Genes in Basal Cell Carcinomas

2001 • 157 citations

The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted

1998 • 154 citations

Targeted overexpression of transforming growth factor alpha in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squamous papillomas.

1993 • 153 citations

Splitting Hairs

1998 • 151 citations

PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer

2001 • 140 citations

Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v‐Ha‐ras oncogene

1993 • 123 citations

TGF-β antagonists: Why suppress a tumor suppressor?

2002 • 123 citations

Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis.

1992 • 107 citations

TGF-β antagonists: Why suppress a tumor suppressor?

2002 • 106 citations

Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation

2002 • 93 citations

Benign clonal keratinocyte patches with p53 mutations show no genetic link to synchronous squamous cell precancer or cancer in human skin.

1997 • 88 citations

Monstrous attempts at adnexogenesis: regulating hair follicle progenitors through Sonic hedgehog signaling

2001 • 84 citations

Pathology of tumours in laboratory animals

1975 • 83 citations

Inducible activation of Ras and Raf in adult epidermis.

2003 • 81 citations

A tumor-associated β1 integrin mutation that abrogates epithelial differentiation control

2003 • 74 citations

Perturbation in connexin 43 and connexin 26 gap-junction expression in mouse skin hyperplasia and neoplasia

1996 • 73 citations

p19^ARF‐independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes

2001 • 59 citations

Restoration of growth potential in paraclones of human keratinocytes by a viral oncogene.

1989 • 59 citations

A multihit, multistage model of chemical carcinogenesis

1999 • 58 citations

Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion.

2001 • 58 citations

Delta regulates keratinocyte spreading and motility independently of differentiation

2001 • 55 citations

Adult epidermal keratinocytes are endowed with pilosebaceous forming abilities.

1997 • 53 citations

‘‘Second Hit’’ in Sebaceous Tumors from Muir–Torre Patients with Germline Mutations in MSH2: Allele Loss is Not the Preferred Mode of Inactivation

2001 • 46 citations

Regulation of Interleukin-1α Expression by Integrins and Epidermal Growth Factor Receptor in Keratinocytes from a Mouse Model of Inflammatory Skin Disease

2003 • 44 citations

Induction of Skin Papillomas, Carcinomas, and Sarcomas in Mice in Which the Connexin 43 Gene is Heterologously Deleted

2000 • 17 citations

Muir-Torre Syndrome

1998 • 10 citations