A multihit, multistage model of chemical carcinogenesis

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

Mutation and Cancer: A Model for Human Carcinogenesis2

1981 • 1,102 citations

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

1986 • 865 citations

GENETICS OF HUMAN CANCER

1986 • 565 citations

Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas

1984 • 550 citations

Cancer and ageing in mice and men

1975 • 466 citations

Malignant conversion of mouse skin tumours is increased by tumour initiators and unaffected by tumour promoters

1983 • 325 citations

Genetic changes in skin tumor progression: Correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7

1990 • 270 citations

FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin

1993 • 169 citations

Expression of simple epithelial type cytokeratins in stratified epithelia as detected by immunolocalization and hybridization in situ.

1988 • 168 citations

Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene.

1993 • 153 citations

Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice.

1991 • 139 citations

Specific genetic analysis of microscopic tissue after selective ultraviolet radiation fractionation and the polymerase chain reaction.

1992 • 126 citations

Overexpression of cyclin D1 in mouse skin carcinogenesis.

1993 • 122 citations

Alterations of the p53 tumor suppressor gene during mouse skin tumor progression.

1991 • 117 citations

Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7.

1991 • 116 citations

The suprabasal expression of alpha 6 beta 4 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis.

1993 • 114 citations

Skin tumors: experimental and clinical aspects.

1989 • 101 citations

Aberrant expression during two‐stage mouse skin carcinogenesis of a type 147‐kDa keratin, k13, normally associated with terminal differentiation of internal stratified epithelia

1988 • 98 citations

Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors.

1990 • 98 citations

Sequential trisomization of chromosomes 6 and 7 in mouse skin premalignant lesions

1989 • 96 citations

The Initiation-Promotion-Progression Model of Rat Hepatocarcinogenesis

1993 • 82 citations

Perturbation in connexin 43 and connexin 26 gap-junction expression in mouse skin hyperplasia and neoplasia

1996 • 73 citations

Discordant transforming growth factor beta 1 RNA and protein localization during chemical carcinogenesis of the skin.

1992 • 72 citations

Evidence for autocrine/paracrine growth stimulation by transforming growth factor‐α during the process of skin tumor promotion

1991 • 72 citations

A new protocol and its rationale for the study of initiation and promotion of carcinogenesis in rat liver

1981 • 71 citations

Aberrant expression of the simple epithelial type II keratin 8 by mouse skin carcinomas but not papillomas

1992 • 58 citations

Early expression of type I K13 keratin in the progression of mouse skin papillomas

1990 • 58 citations

Detection of dibenzo[a,l]pyrene-induced H-ras codon 61 mutant genes in preneoplastic SENCAR mouse skin using a new PCR–RFLP method

1998 • 51 citations

Birth and death/differentiation rates of papillomas in mouse skin

1992 • 42 citations

Characterization of benzo[a]pyrene-initiated mouse skin papillomas for Ha-ras mutations and protein kinase C levels

1993 • 40 citations

Increased expression of G1 cyclins and cyclin-dependent kinases during tumor progression of chemically induced mouse skin neoplasms.

1997 • 35 citations

Genetic alterations cooperate with v-Ha-ras to accelerate multistage carcinogenesis in TG.AC transgenic mouse skin.

1995 • 27 citations

Localization and Expression of Cornifin-α/SPRR1 in Mouse Epidermis, Anagen Follicles, and Skin Neoplasms

1996 • 26 citations

The skin tumorigenic and carcinogenic effects of different doses, numbers of dose fractions amd concentrations of 7,12-dimethylbenz[a]anthracene in acetone applied on hairless mouse epidermis. Possible implications for human carcinogenesis

1991 • 18 citations

Characterization of skin tumor promotion by mirex: structure-activity relationships, sexual dimorphism and presence of Ha-ras mutation

1993 • 15 citations

Keratin expression in mouse epidermal tumors.

1989 • 12 citations

Diacylglycerol is an effector of the clonal expansion of cells containing activated Ha-ras genes

1993 • 11 citations