Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog

Seria cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is

1975 • 4,443 citations

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

1996 • 2,021 citations

Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome

1996 • 1,850 citations

HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

1995 • 1,380 citations

Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

1996 • 1,140 citations

Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma

1975 • 1,113 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

The secret life of the hair follicle

1992 • 919 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus

1996 • 768 citations

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

1996 • 756 citations

Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog

1997 • 712 citations

BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription

1993 • 668 citations

Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly

1996 • 646 citations

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1994 • 624 citations

The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal

1996 • 591 citations

A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180.

1993 • 583 citations

The world according to bedgebog

1997 • 549 citations

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

1995 • 505 citations

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

1996 • 474 citations

Histopathology of the Skin

1990 • 453 citations

Biology of basal cell carcinoma (Part I)

1991 • 427 citations

Antibody markers of basal cells in complex epithelia

1990 • 382 citations

Proteolytic Processing Yields Two Secreted Forms of Sonic hedgehog

1995 • 309 citations

High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC

1995 • 252 citations

Involucrin Expression in Normal and Neoplastic Human Skin: A Marker for Keratinocyte Differentiation

1984 • 210 citations

Cloning, Expression, and Chromosomal Location of SHH and IHH: Two Human Homologues of the Drosophila Segment Polarity Gene Hedgehog

1995 • 191 citations

Corrective gene transfer in the human skin disorder lamellar ichthyosis

1996 • 166 citations

Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease

1994 • 136 citations

Regulation of wingless transcription in the Drososphila embryo

1993 • 135 citations

Evaluation of Human Skin Reconstituted from Composite Grafts of Cultured Keratinocytes and Human Acellular Dermis Transplanted to Athymic Mice

1996 • 119 citations

Signalling by hedgehog family proteins in Drosophila and vertebrate development

1995 • 107 citations

bcl-2 Expression in Primary Malignancies of the Skin

1995 • 106 citations

Biology of basal cell carcinoma (Part II)

1991 • 104 citations

Basement membrane proteins kalinin and nicein are structurally and immunologically identical.

1993 • 96 citations

Characterization of Two Monoclonal Antibodies to Human Epidermal Keratohyalin: Reactivity With Filaggrin and Related Proteins

1987 • 88 citations

Transglutaminase 1 Delivery to Lamellar Ichthyosis Keratinocytes

1996 • 83 citations

Expression and Topography of Integrins and Basement Membrane Proteins in Epidermal Carcinomas: Basal but not Squamous Cell Carcinomas Display Loss of ∝6β4 and BM-600/Nicein

1993 • 66 citations

Expression pattern of the bullous pemphigoid-180 antigen in normal and neoplastic epithelia

1995 • 64 citations

A Murine Model of Cystic Fibrosis

1995 • 54 citations

Transgenic models of epidermal neoplasia and multistage carcinogenesis.

1996 • 29 citations

Hedgehogs in the clinic

1996 • 4 citations

Deleted Work

1955 • 0 citations