Regulating self-tolerance by deregulating gene expression

DNA methylation patterns and epigenetic memory

2002 • 6,778 citations

Epigenetic Reprogramming in Mammalian Development

2001 • 2,978 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

2002 • 1,231 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

2001 • 687 citations

DNA Methylation Is the Primary Silencing Mechanism for a Set of Germ Line- and Tumor-Specific Genes with a CpG-Rich Promoter

1999 • 589 citations

The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

1996 • 552 citations

Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene

2003 • 420 citations

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

2000 • 399 citations

Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR

2003 • 361 citations

Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters

2004 • 352 citations

Autoimmune Regulator Is Expressed in the Cells Regulating Immune Tolerance in Thymus Medulla

1999 • 293 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

Promiscuous gene expression and central T-cell tolerance: more than meets the eye

2002 • 198 citations

Transcription of a Broad Range of Self-Antigens in Human Thymus Suggests a Role for Central Mechanisms in Tolerance Toward Peripheral Antigens

1998 • 173 citations

Localization of the APECED protein in distinct nuclear structures

1999 • 154 citations

AIRE Functions As an E3 Ubiquitin Ligase

2004 • 145 citations

Human thymus contains 2 distinct dendritic cell populations

2001 • 143 citations

Autoimmune regulator: from loss of function to autoimmunity

2003 • 137 citations

The making of a spermatozoon: A molecular perspective

1995 • 127 citations

Promoter Methylation Controls the Expression of MAGE2, 3 and 4 Genes in Human Cutaneous Melanoma

2002 • 116 citations

The genetic background of autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy and its autoimmune disease components

2002 • 114 citations

Aire: an update

2004 • 102 citations

Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus

2002 • 98 citations

Subcellular Location and Expression Pattern of Autoimmune Regulator (Aire), the Mouse Orthologue for Human Gene Defective in Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)

2001 • 97 citations

Evidence for local control of gene expression in the epidermal differentiation complex

2002 • 79 citations

Characterization of Regulatory Elements and Methylation Pattern of the Autoimmune Regulator (AIRE) Promoter

2003 • 63 citations

Tissue-specific methylation patterns and expression of the human apolipoprotein AI gene.

1990 • 54 citations

Immunological Findings in Patients with Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED) and their Family Members: Are Heterozygotes Subclinically Affected?

2002 • 31 citations

Hypomethylation of the interphotoreceptor retinoid-binding protein (IRBP) promoter and first exon is linked to expression of the gene

1990 • 23 citations