β-Adrenergic receptors and their interacting proteins

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Structure and Regulation of Voltage-Gated Ca²⁺ Channels

2000 • 2,264 citations

G PROTEIN–COUPLED RECEPTOR KINASES

1998 • 1,335 citations

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 • 1,264 citations

Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

1997 • 1,247 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

PDZ Domains and the Organization of Supramolecular Complexes

2001 • 1,203 citations

The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein

1992 • 1,180 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

Molecular Characterization of the Human β ₃ -Adrenergic Receptor

1989 • 1,071 citations

A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation

1996 • 758 citations

A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor

1999 • 673 citations

Detection of β ₂ -adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

2000 • 631 citations

The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

1998 • 582 citations

Identification of EBP50: A PDZ-containing Phosphoprotein that Associates with Members of the Ezrin-Radixin-Moesin Family

1997 • 582 citations

Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function

2002 • 580 citations

Cloning of the cDNA for the human beta 1-adrenergic receptor.

1987 • 577 citations

Opposing Effects of β ₁ - and β ₂ -Adrenergic Receptors on Cardiac Myocyte Apoptosis

1999 • 557 citations

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.

1992 • 531 citations

Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins

2002 • 519 citations

Desensitization of G-protein-coupled Receptors

1999 • 510 citations

A β ₂ Adrenergic Receptor Signaling Complex Assembled with the Ca ²⁺ Channel Ca _v 1.2

2001 • 509 citations

Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer

2002 • 466 citations

β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

1989 • 451 citations

cAMP-mediated inhibition of the epithelial brush border Na ⁺ /H ⁺ exchanger, NHE3, requires an associated regulatory protein

1997 • 426 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

The β ₂ -Adrenergic Receptor Delivers an Antiapoptotic Signal to Cardiac Myocytes Through G _i -Dependent Coupling to Phosphatidylinositol 3′-Kinase

2000 • 415 citations

A C-terminal motif found in the β ₂ -adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na ⁺ /H ⁺ exchanger regulatory factor family of PDZ proteins

1998 • 406 citations

SH2 domains, interaction modules and cellular wiring

2001 • 394 citations

The SH3p4/Sh3p8/SH3p13 protein family: Binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain

1997 • 383 citations

G protein regulation of potassium ion channels.

1998 • 379 citations

Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger.

1995 • 344 citations

Oligomerization of opioid receptors with beta 2-adrenergic receptors: A role in trafficking and mitogen-activated protein kinase activation

2000 • 326 citations

Targeted Disruption of the β2 Adrenergic Receptor Gene

1999 • 325 citations

Phosphorylation and Desensitization of the Human β1-Adrenergic Receptor

1995 • 317 citations

Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

2000 • 304 citations

A Novel Multiple PDZ Domain-containing Molecule Interacting withN-Methyl-d-aspartateReceptors and Neuronal Cell Adhesion Proteins

1998 • 290 citations

β-Adrenergic Regulation of Synaptic NMDA Receptors by cAMP-Dependent Protein Kinase

1996 • 280 citations

Cardiovascular and Metabolic Alterations in Mice Lacking Both β1- and β2-Adrenergic Receptors

1999 • 279 citations

Monitoring Receptor Oligomerization Using Time-resolved Fluorescence Resonance Energy Transfer and Bioluminescence Resonance Energy Transfer

2001 • 257 citations

STRUCTURE AND FUNCTION OF THE β₃-ADRENERGIC RECEPTOR

1997 • 249 citations

Beta 1-adrenoceptor stimulation and beta 2-adrenoceptor stimulation differ in their effects on contraction, cytosolic Ca2+, and Ca2+ current in single rat ventricular cells.

1993 • 241 citations

Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.

1993 • 227 citations

GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP

1998 • 222 citations

Assembly of an A kinase-anchoring protein–β 2 -adrenergic receptor complex facilitates receptor phosphorylation and signaling

2000 • 219 citations

β1/β2-Adrenergic Receptor Heterodimerization Regulates β2-Adrenergic Receptor Internalization and ERK Signaling Efficacy

2002 • 210 citations

β-Adrenergic Receptor Subtypes Differentially Affect Apoptosis in Adult Rat Ventricular Myocytes

2000 • 209 citations

Dynamic Complexes of β2-Adrenergic Receptors with Protein Kinases and Phosphatases and the Role of Gravin

1999 • 208 citations

Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences

2002 • 207 citations

Platelet-Derived Growth Factor Receptor Association with Na⁺/H⁺ Exchanger Regulatory Factor Potentiates Receptor Activity

2000 • 206 citations

Direct Binding of Activated c-Src to the β3-Adrenergic Receptor Is Required for MAP Kinase Activation

2000 • 204 citations

Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice.

2001 • 200 citations

Beta 2-adrenergic receptor-stimulated increase in cAMP in rat heart cells is not coupled to changes in Ca2+ dynamics, contractility, or phospholamban phosphorylation.

1994 • 199 citations

The β3-Adrenergic Receptor Activates Mitogen-activated Protein Kinase in Adipocytes through a Gi-dependent Mechanism

1999 • 179 citations

Identification of the Major Synaptojanin-binding Proteins in Brain

1997 • 169 citations

β1-Adrenergic Receptor Association with PSD-95

2000 • 166 citations

Atrophin-1, the DRPLA Gene Product, Interacts with Two Families of WW Domain-Containing Proteins

1998 • 165 citations

Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79

2001 • 158 citations

The Human Testis Determining Factor SRY Binds a Nuclear Factor Containing PDZ Protein Interaction Domains

1997 • 157 citations

Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the β1-adrenergic receptor

1999 • 145 citations

Binding of the β2 Adrenergic Receptor toN-Ethylmaleimide-sensitive Factor Regulates Receptor Recycling

2001 • 137 citations

β1-Adrenergic Receptor Association with the Synaptic Scaffolding Protein Membrane-associated Guanylate Kinase Inverted-2 (MAGI-2)

2001 • 132 citations

PDZ-GEF1, a Guanine Nucleotide Exchange Factor Specific for Rap1 and Rap2

1999 • 126 citations

Gravin-mediated Formation of Signaling Complexes in β2-Adrenergic Receptor Desensitization and Resensitization

2000 • 121 citations

Heterodimerization of α2A- and β1-Adrenergic Receptors

2003 • 121 citations

Ultrastructural localization of β-adrenergic receptor-like immunoreactivity in the cortex and neostriatum of rat brain

1987 • 115 citations

Effect of catecholamines on fluid reabsorption by the isolated proximal convoluted tubule

1980 • 110 citations

The PDZ Binding Motif of the β1 Adrenergic Receptor Modulates Receptor Trafficking and Signaling in Cardiac Myocytes

2002 • 109 citations

Distinct regulation of beta 1- and beta 2-adrenergic receptors in Chinese hamster fibroblasts.

1992 • 106 citations

c-Src Tyrosine Kinase Binds the β2-Adrenergic Receptor via Phospho-Tyr-350, Phosphorylates G-protein-linked Receptor Kinase 2, and Mediates Agonist-induced Receptor Desensitization

2001 • 105 citations

nRap GEP: A Novel Neural GDP/GTP Exchange Protein for Rap1 Small G Protein That Interacts with Synaptic Scaffolding Molecule (S-SCAM)

1999 • 105 citations

GIPC Interacts with the β1-Adrenergic Receptor and Regulates β1-Adrenergic Receptor-mediated ERK Activation

2003 • 103 citations

Cross-talk between tyrosine kinase and G-protein-linked receptors. Phosphorylation of beta 2-adrenergic receptors in response to insulin.

1992 • 102 citations

A proline-rich region of the third intracellular loop imparts phenotypic beta 1-versus beta 2-adrenergic receptor coupling and sequestration

1994 • 98 citations

The Scaffold Protein Gravin (cAMP-dependent Protein Kinase-anchoring Protein 250) Binds the β2-Adrenergic Receptor via the Receptor Cytoplasmic Arg-329 to Leu-413 Domain and Provides a Mobile Scaffold during Desensitization

2001 • 96 citations

Interaction with β-Arrestin Determines the Difference in Internalization Behavior between β1- and β2-Adrenergic Receptors

2000 • 92 citations

Insulin Stimulates Sequestration of β-Adrenergic Receptors and Enhanced Association of β-Adrenergic Receptors with Grb2 via Tyrosine 350

1998 • 87 citations

RA-GEF, a Novel Rap1A Guanine Nucleotide Exchange Factor Containing a Ras/Rap1A-associating Domain, Is Conserved between Nematode and Humans

1999 • 87 citations

Subtype Specific Roles of β-Adrenergic Receptors in Apoptosis of Adult Rat Ventricular Myocytes

2002 • 85 citations

Endophilin-1: a multifunctional protein

2002 • 83 citations

A Novel Interaction between Adrenergic Receptors and the α-Subunit of Eukaryotic Initiation Factor 2B

1997 • 74 citations

Antibodies to the beta-adrenergic receptor: attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain.

1983 • 70 citations

Direct Binding of the β1 Adrenergic Receptor to the Cyclic AMP-Dependent Guanine Nucleotide Exchange Factor CNrasGEF Leads to Ras Activation

2002 • 66 citations

Three Isoforms of Synaptic Scaffolding Molecule and Their Characterization

2000 • 65 citations

Opposite Action of β1- and β2-Adrenergic Receptors on Ca_V1 L-Channel Current in Rat Adrenal Chromaffin Cells

2003 • 64 citations

G Protein-coupled Receptor Kinase 5 Regulates β1-Adrenergic Receptor Association with PSD-95

2002 • 61 citations

Glycosylation of β1-adrenergic receptors regulates receptor surface expression and dimerization

2002 • 60 citations

Screening for Protein-Protein Interactions in the Yeast Two-Hybrid System

2003 • 56 citations

Alpha and beta adrenergic agonists stimulate water absorption in the rat proximal tubule

1982 • 38 citations

Sustained enhancement of NMDA receptor-mediated synaptic potential by isoproterenol in rat amygdalar slices

1992 • 36 citations

Enhancement of NMDA receptor-mediated synaptic potential by isoproterenol is blocked by Rp-adenosine 3′,5′-cyclic monophosphothioate

1993 • 31 citations

pp60Src Mediates Insulin-stimulated Sequestration of the β₂-Adrenergic Receptor: Insulin Stimulates pp60Src Phosphorylation and Activation

2002 • 22 citations

Identification of novel G protein-coupled receptor-interacting proteins

2002 • 10 citations