Gravin-mediated Formation of Signaling Complexes in β2-Adrenergic Receptor Desensitization and Resensitization

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

1996 • 1,329 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION

1998 • 1,074 citations

G Protein-coupled Receptors

1998 • 1,033 citations

Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

1996 • 938 citations

Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

1995 • 911 citations

Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase

1998 • 542 citations

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.

1992 • 445 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

1990 • 393 citations

G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins

1996 • 332 citations

Arrestin/Clathrin Interaction

1997 • 290 citations

Molecular Glue: Kinase Anchoring and Scaffold Proteins

1996 • 264 citations

G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins

1996 • 264 citations

Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein

1997 • 254 citations

Phorbol diesters promote β-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes

1984 • 238 citations

Clathrin-mediated Endocytosis of the β-Adrenergic Receptor Is Regulated by Phosphorylation/Dephosphorylation of β-Arrestin1

1997 • 238 citations

Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.

1993 • 234 citations

Role of Clathrin-mediated Endocytosis in Agonist-induced Down-regulation of the β2-Adrenergic Receptor

1998 • 211 citations

Arrestin/Clathrin Interaction

1997 • 209 citations

Dynamic Complexes of β2-Adrenergic Receptors with Protein Kinases and Phosphatases and the Role of Gravin

1999 • 208 citations

Mechanisms of β-Adrenergic Receptor Desensitization and Resensitization

1997 • 193 citations

Modulation of the Arrestin-Clathrin Interaction in Cells

1997 • 193 citations

Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C.

1996 • 165 citations

Phosphorylation and Activation of β-Adrenergic Receptor Kinase by Protein Kinase C

1995 • 160 citations

Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity.

1984 • 154 citations

Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.

1986 • 154 citations

Protein kinase C: subcellular redistribution by increased Ca2+ influx. Evidence that Ca2+-dependent subcellular redistribution of protein kinase C is involved in potentiation of beta-adrenergic stimulation of pineal cAMP and cGMP by K+ and A23187.

1988 • 130 citations

Regulation of the AKAP79-Protein Kinase C Interaction by Ca2+/Calmodulin

1997 • 116 citations

Pathways of internalization of the hCG/LH receptor: immunoelectron microscopic studies in Leydig cells and transfected L-cells.

1992 • 102 citations

The β-Adrenergic Receptor Is a Substrate for the Insulin Receptor Tyrosine Kinase

1996 • 98 citations

Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and beta-adrenergic receptor kinase reveal distinctive cell-type-specific roles in agonist-induced desensitization.

1994 • 95 citations

Human Muscarinic Cholinergic Receptor Hm1 Internalizes via Clathrin-coated Vesicles

1996 • 80 citations

Phosphorylation of Tyrosyl Residues 350/354 of the β-Adrenergic Receptor Is Obligatory for Counterregulatory Effects of Insulin

1995 • 72 citations

G Protein–Coupled Receptors and Receptor Kinases: From Molecular Biology to Potential Therapeutic Applications

1996 • 44 citations

Identification of a specific domain in the beta-adrenergic receptor required for phorbol ester-induced inhibition of catecholamine-stimulated adenylyl cyclase.

1990 • 44 citations

Regulating expression and function of G-protein-linked receptors

1996 • 41 citations

Effects of protein kinase inhibitor (1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7) on protein kinase C activity and adrenergic stimulation of cAMP and cGMP in rat pinealocytes

1988 • 37 citations

Potential Regulatory Roles for G Protein-Coupled Receptor Kinases and β-Arrestins in Gonadotropin-Releasing Hormone Receptor Signaling*

1998 • 34 citations

G‐protein linked receptors: a family probed by molecular cloning and mutagenesis procedures

1992 • 31 citations

Protein Kinase C Deficiency Blocks Recovery from Agonist-induced Desensitization

1996 • 30 citations

Restricted endothelial cell expression of gravin in vivo

1994 • 27 citations

Effects of agonist and phorbol ester on adrenergic receptors of DDT1 MF-2 cells.

1987 • 23 citations

Protein kinase C potentiates isoproterenol‐mediated cyclic AMP production without modifying the homologous desensitization process in J774 cells

1987 • 19 citations

Chapter 15 The role of G-protein coupled receptor kinases in the regulation of muscarinic cholinergic receptors

1996 • 17 citations

Characterization of the β2-adrenoceptor-dependent adenylate cyclase of A431 epidermoid carcinoma cells

1987 • 12 citations

A phorbol ester augments cAMP content and adenylyl cyclase activity in neonatal rat cardiac myocytes despite reduced adrenoceptor density

1993 • 10 citations

Neutrophil beta-adrenergic receptor responses are potentiated by acute exposure to phorbol ester without changes in receptor distribution or coupling

1991 • 5 citations