Atrophin-1, the DRPLA Gene Product, Interacts with Two Families of WW Domain-Containing Proteins

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Improved method for high efficiency transformation of intact yeast cells

1992 • 3,258 citations

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

1997 • 2,762 citations

Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation

1997 • 2,184 citations

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

1995 • 1,861 citations

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

1993 • 1,459 citations

The I.M.A.G.E. Consortium: An Integrated Molecular Analysis of Genomes and Their Expression

1996 • 1,132 citations

Unstable expansion of CAG repeat in hereditary dentatorubral–pallidoluysian atrophy (DRPLA)

1994 • 1,122 citations

Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases.

1994 • 1,065 citations

Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases

1995 • 994 citations

GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors

1997 • 866 citations

Intranuclear Inclusions of Expanded Polyglutamine Protein in Spinocerebellar Ataxia Type 3

1997 • 821 citations

Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.

1995 • 804 citations

Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis

1996 • 789 citations

A huntingtin-associated protein enriched in brain with implications for pathology

1995 • 597 citations

The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.

1995 • 556 citations

Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun.

1992 • 531 citations

Regulation of the Yeast HO Gene

1985 • 526 citations

Widespread expression of Huntington's disease gene (IT15) protein product

1995 • 516 citations

Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH

1996 • 435 citations

Intranuclear Neuronal Inclusions in Huntington's Disease and Dentatorubral and Pallidoluysian Atrophy: Correlation between the Density of Inclusions andIT15CAG Triplet Repeat Length

1998 • 421 citations

Intranuclear Neuronal Inclusions: A Common Pathogenic Mechanism for Glutamine-Repeat Neurodegenerative Diseases?

1997 • 392 citations

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

1997 • 384 citations

The WW domain: a signalling site in dystrophin?

1994 • 380 citations

end3 and end4: two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae.

1993 • 380 citations

A method for constructing radiation hybrid maps of whole genomes

1994 • 373 citations

Huntingtin Is Ubiquitinated and Interacts with a Specific Ubiquitin-conjugating Enzyme

1996 • 365 citations

HIP-I: A huntingtin interacting protein isolated by the yeast two-hybrid system

1997 • 335 citations

NPI1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin—protein ligase

1995 • 331 citations

The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants.

1994 • 319 citations

Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae

1993 • 289 citations

Familial myoclonus epilepsy and choreoathetosis

1982 • 288 citations

When more is less: Pathogenesis of glutamine repeat neurodegenerative diseases

1995 • 263 citations

Cell signalling: MAGUK magic

1996 • 248 citations

Novel Triplet Repeat Containing Genes in Human Brain: Cloning, Expression, and Length Polymorphisms

1993 • 210 citations

Structure and expression of the gene responsible for the triplet repeat disorder, dentatorubral and pallidoluysian atrophy (DRPLA)

1994 • 202 citations

MAGI-1, a Membrane-associated Guanylate Kinase with a Unique Arrangement of Protein-Protein Interaction Domains

1997 • 196 citations

Genes with triplet repeats: candidate mediators of neuropsychiatric disorders

1993 • 187 citations

Dentatorubral‐pallidoluysian atrophy: Clinical features are closely related to unstable expansions of trinucleotide (CAG) repeat

1995 • 164 citations

Identification of Novel Human WW Domain-containing Proteins by Cloning of Ligand Targets

1997 • 163 citations

Abnormal gene product identified in hereditary dentatorubral–pallidoluysian atrophy (DRPLA) brain

1995 • 160 citations

Spinocerebellar ataxia type-1 and spinobulbar muscular atrophy gene products interact with glyceraldehyde-3-phosphate dehydrogenase

1996 • 148 citations

DNA analysis in hereditary dentatorubral-pallidoluysian atrophy

1995 • 140 citations

The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole

1996 • 124 citations

Unusual form of cerebellar ataxia

1958 • 112 citations

Huntington Disease and the Related Disorder, Dentatorubral-Pallidoluysian Atrophy (DRPLA)

1997 • 99 citations

Subcellular Localization and Ubiquitin-conjugating Enzyme (E2) Interactions of Mammalian HECT Family Ubiquitin Protein Ligases

1997 • 86 citations

The rsp5-domain is shared by proteins of diverse functions

1995 • 63 citations

MOP2 (SLA2) Affects the Abundance of the Plasma Membrane H+-ATPase of Saccharomyces cerevisiae

1995 • 56 citations

DRPLA gene (Atrophin-1) sequence and mRNA expression in human brain

1996 • 41 citations

Ubiquitin-reactive neurites in cerebral cortex of subjects with Huntington's chorea: a pathological correlate of dementia?

1993 • 31 citations

Expression and distribution of the dentatorubral-pallidoluysian atrophy gene product (atrophin-1/drplap) in neuronal and non-neuronal tissues

1997 • 25 citations

Regional and cellular expression of the dentatorubral‐pallidoluysian atrophy gene in brains of normal and affected individuals

1997 • 15 citations

Expression of dentatorubral-pallidoluysian atrophy (DRPLA) proteins in patients

1997 • 13 citations